Evaluating Pain Control Strategies in Postpartum Patients on Opioid Use Disorder Medications.
NCT ID: NCT06617949
Last Updated: 2025-10-23
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
EARLY_PHASE1
20 participants
INTERVENTIONAL
2025-01-16
2028-12-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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NON_RANDOMIZED
PARALLEL
TREATMENT
NONE
Study Groups
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Transverse abdominal Plane(TAP) Block with long acting Exparel
A subset of participants (n=15) will be divided into three different arms: A.) Postoperative Epidural infusion for 24-36hrs B.) Hydromorphone Patient Controlled Analgesia (PCA) with Preservative free Morphine via epidural for 36hrs C.) Transverse abdominal Plane(TAP) Block with long acting Exparel.
Regional Anesthesia
Transverse abdominal Plane(TAP) Block with long acting Exparel placed by a regional anesthesiologist.
Postoperative Epidural infusion for 24-36hrs
A subset of participants (n=15) will be divided into three different arms: A.) Postoperative Epidural infusion for 24-36hrs B.) Hydromorphone Patient Controlled Analgesia (PCA) with Preservative free Morphine via epidural for 36hrs C.) Transverse abdominal Plane(TAP) Block with long acting Exparel.
Epidural local anesthetic infusion
Epidural group will receive pain control via a local anesthetic intermediate bolus infusion
Hydromorphone Patient Controlled Analgesia (PCA),Preservative free Morphine via epidural for 36hrs
A subset of participants (n=15) will be divided into three different arms: A.) Postoperative Epidural infusion for 24-36hrs B.) Hydromorphone Patient Controlled Analgesia (PCA) with Preservative free Morphine via epidural for 36hrs C.) Transverse abdominal Plane(TAP) Block with long acting Exparel.
Hydromorphone Patient Controlled Analgelsic
This group will be administered epidural PCA as a modality for pain control post cesarian section
Interventions
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Regional Anesthesia
Transverse abdominal Plane(TAP) Block with long acting Exparel placed by a regional anesthesiologist.
Hydromorphone Patient Controlled Analgelsic
This group will be administered epidural PCA as a modality for pain control post cesarian section
Epidural local anesthetic infusion
Epidural group will receive pain control via a local anesthetic intermediate bolus infusion
Eligibility Criteria
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Inclusion Criteria
* Inclusion criteria include being a parturient with Substance use disorder (SUD) and age 18-35
Exclusion Criteria:
* Exclusion criteria include having a diagnosed medical condition(allergies to medication, pathology such as severe aortic stenosis excluding patients from receiving an epidural etc) that will exempt patient from intervention arm of the study.
18 Years
40 Years
FEMALE
No
Sponsors
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Medical College of Wisconsin
OTHER
Responsible Party
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Christopher Fadumiye
Assistant Professor
Locations
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Froedtert Hospital Milwaukee, Wisconsin 53226
Milwaukee, Wisconsin, United States
Froedtert Hospital
Milwaukee, Wisconsin, United States
Countries
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Central Contacts
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Facility Contacts
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Christopher Fadumiye
Role: primary
Other Identifiers
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PRO00052798
Identifier Type: -
Identifier Source: org_study_id
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