Phenotypes of Preschool Wheezing Among Children Attending Sohag University Hospital

NCT ID: NCT06603584

Last Updated: 2024-09-19

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

100 participants

Study Classification

OBSERVATIONAL

Study Start Date

2024-06-04

Study Completion Date

2025-04-04

Brief Summary

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Wheezing in preschool children is very common, with a wide differential diagnosis. It is essential to be sure of the exact sound that parents are describing; the term 'wheeze' is often applied to non-specific sound.Approximately one-third of children are diagnosed with wheeze in the first 3 years of life, making wheeze one of the commonest respiratory symptoms.The differential diagnosis of wheeze is wide, and different management strategies are needed depending on the underlying phenotype. The word 'wheeze' is used to describe many different sounds. That can be heard by both clincians and parent. Even if true wheeze is heard, this should not be automatically assumed to be due to bronchospasm. Airway narrowing by mucus will produce true wheeze but does not respond to bronchodilators. Similarly, airway malacia, either related to intrinsic airway wall defects or loss of alveolar tethering points, are also causes of bronchodilatorunresponsive wheeze; indeed, bronchodilators, by reducing airway smooth muscle tone, may actually worsen airway narrowing.

Detailed Description

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Conditions

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Wheezing

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

RETROSPECTIVE

Study Groups

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group A

Bronchial Asthma

Chest x- Rays

Intervention Type RADIATION

prebronchial Thicknening - Right upper lobe Patches suggesting Aspiration -Collapsing lobe

group B

Chronic Aspiration

Chest x- Rays

Intervention Type RADIATION

prebronchial Thicknening - Right upper lobe Patches suggesting Aspiration -Collapsing lobe

group C

Primary Ciliary Dyskinesia

Chest x- Rays

Intervention Type RADIATION

prebronchial Thicknening - Right upper lobe Patches suggesting Aspiration -Collapsing lobe

group D

Cystic Fibrosis

Chest x- Rays

Intervention Type RADIATION

prebronchial Thicknening - Right upper lobe Patches suggesting Aspiration -Collapsing lobe

Interventions

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Chest x- Rays

prebronchial Thicknening - Right upper lobe Patches suggesting Aspiration -Collapsing lobe

Intervention Type RADIATION

Eligibility Criteria

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Inclusion Criteria

* patients from the age of one to five years with recurrent wheezing

Exclusion Criteria

* Children above 5 years and below one year old.
* Failure to obtain informed consent.
* Children below 6 years with chest diseases other than wheezing
Minimum Eligible Age

2 Years

Maximum Eligible Age

6 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Sohag University

OTHER

Sponsor Role lead

Responsible Party

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Amr Ahmed Gamal Eldin

Resident-pediatric department-sohag hospital university

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Sohag university Hospital

Sohag, , Egypt

Site Status RECRUITING

Countries

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Egypt

Central Contacts

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Amr A Farghal, resident

Role: CONTACT

01020479524

Mostfa A Mohammed, assistant professor

Role: CONTACT

Facility Contacts

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Magdy M Amin, professor

Role: primary

References

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Fitzpatrick AM, Bacharier LB, Guilbert TW, Jackson DJ, Szefler SJ, Beigelman A, Cabana MD, Covar R, Holguin F, Lemanske RF Jr, Martinez FD, Morgan W, Phipatanakul W, Pongracic JA, Zeiger RS, Mauger DT; NIH/NHLBI AsthmaNet. Phenotypes of Recurrent Wheezing in Preschool Children: Identification by Latent Class Analysis and Utility in Prediction of Future Exacerbation. J Allergy Clin Immunol Pract. 2019 Mar;7(3):915-924.e7. doi: 10.1016/j.jaip.2018.09.016. Epub 2018 Sep 26.

Reference Type BACKGROUND
PMID: 30267890 (View on PubMed)

Lowe LA, Simpson A, Woodcock A, Morris J, Murray CS, Custovic A; NAC Manchester Asthma and Allergy Study Group. Wheeze phenotypes and lung function in preschool children. Am J Respir Crit Care Med. 2005 Feb 1;171(3):231-7. doi: 10.1164/rccm.200406-695OC. Epub 2004 Oct 22.

Reference Type BACKGROUND
PMID: 15502115 (View on PubMed)

Salehian S, Fleming L, Saglani S, Custovic A. Phenotype and endotype based treatment of preschool wheeze. Expert Rev Respir Med. 2023 Jul-Dec;17(10):853-864. doi: 10.1080/17476348.2023.2271832. Epub 2023 Nov 24.

Reference Type BACKGROUND
PMID: 37873657 (View on PubMed)

Kwong CG, Bacharier LB. Phenotypes of wheezing and asthma in preschool children. Curr Opin Allergy Clin Immunol. 2019 Apr;19(2):148-153. doi: 10.1097/ACI.0000000000000516.

Reference Type BACKGROUND
PMID: 30640211 (View on PubMed)

Other Identifiers

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soh-Med-24-06-20MS

Identifier Type: -

Identifier Source: org_study_id

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