Cholecystectomy Could be Performed in Older Adults With Acute Cholecystitis
NCT ID: NCT06601855
Last Updated: 2024-09-19
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
160 participants
OBSERVATIONAL
2018-09-01
2024-03-31
Brief Summary
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Does cholecystectomy bring harm or benefit to people aged 80, or over the age of 80, who have mild to moderate acute cholecystitis? People who received cholecystectomy are compared to those who did not, for short- and long-term outcomes, with a follow up period for 18 months.
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Detailed Description
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Conditions
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Study Design
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COHORT
RETROSPECTIVE
Study Groups
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Cholecystectomy group
Patient in this group received cholecystectomy, whether immediately, or delayed
Cholecystectomy
Cholecystectomy, whether open or laparoscopic
Non-operative management group
Patients in this group did not receive cholecystectomy during follow up period
No interventions assigned to this group
Interventions
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Cholecystectomy
Cholecystectomy, whether open or laparoscopic
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* Concurrent cholangitis, common bile duct stones, pancreatitis, gallbladder cancer, hepatocellular carcinoma, periampullary cancer
* Received other operations at the same admission other than cholecystectomy
* Discharged against advice of physician
* Received further management at another hospital for acute cholecystitis
80 Years
ALL
Yes
Sponsors
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Taipei Medical University Shuang Ho Hospital
OTHER
Responsible Party
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Principal Investigators
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Chieh-Ju Liao, MD
Role: PRINCIPAL_INVESTIGATOR
Taipei Medical University-Shuang Ho Hospital,Ministry of Health and Welfare
Kuei-Yen Tsai, PhD
Role: PRINCIPAL_INVESTIGATOR
Taipei Medical University-Shuang Ho Hospital,Ministry of Health and Welfare
Locations
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Taipei Medical University-Shuang Ho Hospital,Ministry of Health and Welfare
New Taipei City, , Taiwan
Countries
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References
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Escartin A, Gonzalez M, Cuello E, Pinillos A, Muriel P, Merichal M, Palacios V, Escoll J, Gas C, Olsina JJ. Acute Cholecystitis in Very Elderly Patients: Disease Management, Outcomes, and Risk Factors for Complications. Surg Res Pract. 2019 Feb 3;2019:9709242. doi: 10.1155/2019/9709242. eCollection 2019.
Asbun, Horacio & Shah, Mihir & Ceppa, Eugene & Auyang, Edward. (2020). The SAGES Manual of Biliary Surgery. 10.1007/978-3-030-13276-7
Yetkin G, Uludag M, Oba S, Citgez B, Paksoy I. Laparoscopic cholecystectomy in elderly patients. JSLS. 2009 Oct-Dec;13(4):587-91. doi: 10.4293/108680809X1258998404604.
Lee SJ, Choi IS, Moon JI, Yoon DS, Lee SE, Sung NS, Kwon SU, Bae IE, Roh SJ, Choi WJ. Elective Laparoscopic Cholecystectomy Is Better than Conservative Treatment in Elderly Patients with Acute Cholecystitis After Percutaneous Transhepatic Gallbladder Drainage. J Gastrointest Surg. 2021 Dec;25(12):3170-3177. doi: 10.1007/s11605-021-05067-1. Epub 2021 Jun 25.
Pisano M, Allievi N, Gurusamy K, Borzellino G, Cimbanassi S, Boerna D, Coccolini F, Tufo A, Di Martino M, Leung J, Sartelli M, Ceresoli M, Maier RV, Poiasina E, De Angelis N, Magnone S, Fugazzola P, Paolillo C, Coimbra R, Di Saverio S, De Simone B, Weber DG, Sakakushev BE, Lucianetti A, Kirkpatrick AW, Fraga GP, Wani I, Biffl WL, Chiara O, Abu-Zidan F, Moore EE, Leppaniemi A, Kluger Y, Catena F, Ansaloni L. 2020 World Society of Emergency Surgery updated guidelines for the diagnosis and treatment of acute calculus cholecystitis. World J Emerg Surg. 2020 Nov 5;15(1):61. doi: 10.1186/s13017-020-00336-x.
Wiggins T, Markar SR, Mackenzie H, Jamel S, Askari A, Faiz O, Karamanakos S, Hanna GB. Evolution in the management of acute cholecystitis in the elderly: population-based cohort study. Surg Endosc. 2018 Oct;32(10):4078-4086. doi: 10.1007/s00464-018-6092-5. Epub 2018 Jul 25.
Lee CE, Lee SJ, Moon JI, Choi IS, Yoon DS, Choi WJ, Lee SE, Sung NS, Kwon SU, Bae IE, Roh SJ, Kim SG. Acute cholecystitis in old adults: the impact of advanced age on the clinical characteristics of the disease and on the surgical outcomes of laparoscopic cholecystectomy. BMC Gastroenterol. 2023 Sep 25;23(1):328. doi: 10.1186/s12876-023-02954-6.
Loozen CS, van Santvoort HC, van Duijvendijk P, Besselink MG, Gouma DJ, Nieuwenhuijzen GA, Kelder JC, Donkervoort SC, van Geloven AA, Kruyt PM, Roos D, Kortram K, Kornmann VN, Pronk A, van der Peet DL, Crolla RM, van Ramshorst B, Bollen TL, Boerma D. Laparoscopic cholecystectomy versus percutaneous catheter drainage for acute cholecystitis in high risk patients (CHOCOLATE): multicentre randomised clinical trial. BMJ. 2018 Oct 8;363:k3965. doi: 10.1136/bmj.k3965.
Ramirez-Giraldo C, Venegas-Sanabria LC, Rojas-Lopez S, Avendano-Morales V. Outcomes after laparoscopic cholecystectomy in patients older than 80 years: two-years follow-up. BMC Surg. 2024 Mar 12;24(1):87. doi: 10.1186/s12893-024-02383-6.
Other Identifiers
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jessie21211
Identifier Type: -
Identifier Source: org_study_id
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