Cycling-Based Priming Coordination Training for Enhancing Ataxia Recovery and Brain Plasticity

NCT ID: NCT06600269

Last Updated: 2024-10-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

40 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-10-04

Study Completion Date

2026-08-31

Brief Summary

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Effective walking and balance require not only lower limb muscle strength but also coordinated movement. For individuals with Spinocerebellar Ataxia (SCA), rehabilitation strategies targeting coordination are essential to improving mobility and reducing the burden on caregivers. However, evidence-based rehabilitation approaches for ataxia remain limited.

Recent studies suggest that improvements in motor learning are often accompanied by changes in cortical excitability. Abnormal cortical excitability in SCA patients may hinder rehabilitation efforts, yet priming strategies-such as exercise or specific stimuli-have been shown to enhance motor learning by modulating cortical excitability. Cycling exercise, in particular, has demonstrated the potential to improve coordination and influence cortical plasticity in individuals with SCA, making it a promising priming strategy for coordination training.

This clinical trial aims to:

1. Investigate the priming effect and neural mechanisms of acute cycling exercise on coordination training in patients with SCA.
2. Explore the long-term impact of priming cycling training on cortical plasticity and functional mobility in individuals with SCA.

This study seeks to provide insights into optimized rehabilitation interventions that could enhance the quality of life and independence for people with SCA.

Detailed Description

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Conditions

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Spinocerebellar Ataxias

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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SCA training group

Long-term training

Group Type EXPERIMENTAL

Cycling Training

Intervention Type PROCEDURE

Cycling combined with priming strategies to enhance motor learning tasks. Each session will last for 15 minutes, conducted three times per week, over a period of two weeks.

SCA Control group

Control group

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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Cycling Training

Cycling combined with priming strategies to enhance motor learning tasks. Each session will last for 15 minutes, conducted three times per week, over a period of two weeks.

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

\- Clinical diagnosis of SCA.

Exclusion Criteria

* Musculoskeletal injuries on legs
* Osteoporosis.
* Any peripheral or central nervous system injury or disease patients.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Chang Gung University

OTHER

Sponsor Role lead

Responsible Party

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Ya-Ju Chang

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Chang Gung University

Taoyuan District, , Taiwan

Site Status RECRUITING

Countries

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Taiwan

Facility Contacts

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Ya-Ju Chang, PhD

Role: primary

88632118800 ext. 5515

Other Identifiers

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SCA_001

Identifier Type: -

Identifier Source: org_study_id

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