Could Tai-chi Help Maintain Balance of Spinocerebellar Ataxia Patients

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

21 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-05-13

Study Completion Date

2015-12-02

Brief Summary

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Spinocerebellar atrophy is the most common autosomal dominant inherited ataxia. There are over thirty subtypes, which characterize neurologic features differently. They all have obvious substantial cerebellar atrophies in image, and unstable gait、ataxia. In general a prevalence of about three cases per 100 000 people is assumed, but this may be an underestimate. Progressive neurologic degeneration, in about 10-20 years, will leads to disability or wheelchair-dependent. Accompanying with fatigue, downhill course of the disease often made patients depressive and hopeless. The recent review of researches concludes no effective therapy for the disease. The purpose of the investigator's study is to explore the Tai-chi exercise effect for spinocerebellar ataxia.

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Detailed Description

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Conditions

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Spinocerebellar Ataxias Tai Chi

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

SUPPORTIVE_CARE

Blinding Strategy

NONE

Study Groups

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Tai chi

participants in this group accepted Tai chi exercise and conventional medicine.

Group Type EXPERIMENTAL

Tai chi

Intervention Type BEHAVIORAL

participants were required to receive hospital-based Tai chi training at least once a month, and home-based Tai chi exercise at least three times a week over the next 9 months

conventional medicine

Intervention Type DRUG

participants without Tai chi training still received routine conventional medicine

controlled group

participants were not received Tai chi exercise, but only routine conventional medicine

Group Type ACTIVE_COMPARATOR

conventional medicine

Intervention Type DRUG

participants without Tai chi training still received routine conventional medicine

Interventions

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Tai chi

participants were required to receive hospital-based Tai chi training at least once a month, and home-based Tai chi exercise at least three times a week over the next 9 months

Intervention Type BEHAVIORAL

conventional medicine

participants without Tai chi training still received routine conventional medicine

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* progressive ataxia accompanied with the observation of cerebellar atrophy on magnetic resonance or computed tomography images
* SARA score of less than 20

Exclusion Criteria

* Patients with complicated cerebellar disorders, such as multiple system atrophy, Parkinson-plus syndromes, secondary cerebellar degeneration from encephalitis, trauma, hypoxia, cerebrovascular diseases, and toxic- or drug-induced cerebellar degeneration
* SARA score of larger than 20

Minimum Eligible Age

20 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No