Comparison of SPECT/CT Perfusion and Volumetric CT Volume

NCT ID: NCT06600204

Last Updated: 2025-06-06

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 50 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2024-11-30
• Study Completion Date: 2025-06-01

Brief Summary

The main aim of this study is to show that single photon emission tomography/Computer tomography (SPECT/CT) is a reliable examination to predict postoperative pulmonary function after segmentectomy, by comparing this predicted function to that measured at 1 and 6 months.

Detailed Description

Lung cancer has a high prevalence, incidence and mortality in France and worldwide. Surgical treatment, possible only at an early stage, improves the prognosis of patients. In addition, the increasing accessibility of chest CT scans allows early detection and monitoring of small pulmonary nodules. As a result, more conservative surgical techniques are becoming increasingly important, including segmentectomy.

Among patients for whom it is indicated, the preoperative assessment involves the evaluation of pulmonary function and the prediction of postoperative pulmonary function in order to validate the feasibility of surgery. To do this, several methods have been described: anatomical methods (segment counting), radiological imaging methods (CT, DECT, perfusion MRI), and nuclear imaging methods (planar perfusion and/or ventilation pulmonary scintigraphy, SPECT pulmonary perfusion scintigraphy), some of which are hybrid (SPECT/CT). The use of SPECT/CT to predict postoperative pulmonary function is routinely practiced, and its reliability, accuracy, and concordance with measured postoperative pulmonary function are well demonstrated for pneumectomy and lobectomy. For more conservative surgeries, the data in the literature remain uncertain. However, being able to predict pulmonary function is essential, both to justify the feasibility of the intervention, but also to target the most fragile patients and intensify their postoperative respiratory rehabilitation.

Conditions

Lung Cancer (NSCLC)

Study Design

• Observational Model Type: OTHER
• Study Time Perspective: RETROSPECTIVE

Study Groups

Patients who underwent a single or multiple segmentectomy

Patients who underwent a single or multiple segmentectomy in the thoracic surgery department of the Nancy University Hospital between April 2021 and July 2023

lung scintigraphy

Intervention Type: OTHER

Use the SPECT/CT to predict pulmonary function

Interventions

lung scintigraphy

Use the SPECT/CT to predict pulmonary function

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Person having received full information on the organization of the research and not having opposed the exploitation of this data
• Patients having benefited from a single or multiple segmentectomy within the thoracic surgery department of the CHRU of Nancy during the period April 2021 to June 2023
• Patients having a complete pre-operative assessment (SPECT/CT, volumetric CT and EFR)
• Patients having 2 post-operative assessments (respiratory functional exploration (EFR) at approximately 1 month post-operatively and 6 months post-operatively).

Exclusion Criteria

• Patients who underwent more extensive surgery (lobectomy, pneumectomy) or less extensive surgery (wedge).
• Patient who did not have a complete preoperative assessment (SPECT/CT or volumetric CT or missing respiratory functional exploration EFR).
• Patient who did not have a complete postoperative assessment (missing respiratory functional exploration EFR at 6 months).

NB: the absence of respiratory functional exploration EFR at 1 month postoperatively is not an exclusion criterion

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 95 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Central Hospital, Nancy, France

OTHER

Sponsor Role: lead

Responsible Party

Antoine VERGER

Principal investigator

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

CHRU of NANCY

Vandœuvre-lès-Nancy, , France

Countries

France

Other Identifiers

Retrospective study

Identifier Type: OTHER

Identifier Source: secondary_id

2024PI070

Identifier Type: -

Identifier Source: org_study_id