Clinical Outcomes of Thoracodorsal Artery Flap in Oral and Maxillofacial Reconstruction
NCT ID: NCT06599801
Last Updated: 2024-09-19
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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NOT_YET_RECRUITING
217 participants
OBSERVATIONAL
2024-09-30
2025-09-30
Brief Summary
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Do the clinical characteristics of the thoracodorsal artery perforator flap differ from those of other types of flaps? Does the thoracodorsal artery perforator flap result in better clinical outcomes compared to other types of flaps? After reconstruction with the thoracodorsal artery perforator flap, do patients have better quality of life, speech function and scar healing compared to other types of flaps? Investigators will retrospectively compare the thoracodorsal artery perforator flap with other types of flaps (such as the anterolateral thigh flap, forearm flap, latissimus dorsi flap and fibula flap) to explore the most suitable free flap for facial defect reconstruction in oral squamous cell carcinoma patients.
Participants are oral squamous cell carcinoma patients who previously underwent facial defect reconstruction with different types of flaps. Participants have completed relevant questionnaires at 1, 3, 6 and 12 months post-surgery. The data will be scored and assessed by the investigators.
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Detailed Description
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Functional maxillofacial defect repair has become a mainstream approach in surgical reconstruction. The thoracodorsal artery perforator (TDAP) flap is increasingly favored by oral and maxillofacial surgeons due to its advantages of fewer complications, favorable tissue characteristics and easy access to the latissimus dorsi nerve, making it the preferred option for maxillofacial defect reconstruction.
Postoperative QoL has become an important indicator for evaluating the prognosis of OSCC. In successful cases of OSCC surgery, patients may still experience a decline in QoL due to postoperative complications, oral function impairments and aesthetic issues, leading to a suicide rate much higher than that of other cancer patients. Compared to traditional free flaps, the TDAP flap has less conspicuous donor site scarring, which is hidden under the posterior axillary fold, thus offering significant advantages in aesthetics. Additionally, the motor nerve of the TDAP flap helps achieve functional reconstruction of the maxillofacial area, improving the postoperative QoL for OSCC patients.
In this retrospective study, the investigators will collect clinical data from 217 OSCC patients who underwent different free flap reconstructions at the Oral and Maxillofacial Surgery Department of Sun Yat-sen Memorial Hospital from January 2020 to December 2023. The investigators will assess the QoL, speech ability and scarring of patients using the Washington Quality of Life Scale, Speech Disorder Index Scale and Vancouver Scar Scale. The goal is to evaluate the repair and reconstruction outcomes of the TDAP flap in OSCC patients and to identify the most suitable flap choice for OSCC patients at this stage.
Conditions
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Study Design
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COHORT
RETROSPECTIVE
Study Groups
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Anterolateral thigh flap group
Oral squamous cell carcinoma patients received the reconstruction with anterolateral thigh flaps after tumor resection
Anterolateral thigh flap reconstruction surgery
Oral squamous cell carcinoma patients received the reconstruction with anterolateral thigh flaps after tumor resection
Forearm flap group
Oral squamous cell carcinoma patients received the reconstruction with forearm flaps after tumor resection
Forearm flap reconstruction surgery
Oral squamous cell carcinoma patients received the reconstruction with forearm flaps after tumor resection
Latissimus dorsi flap group
Oral squamous cell carcinoma patients received the reconstruction with latissimus dorsi flaps after tumor resection
Forearm flaps reconstruction surgery
Oral squamous cell carcinoma patients received the reconstruction with forearm flaps after tumor resection
Fibula flap group
Oral squamous cell carcinoma patients received the reconstruction with Fibula flaps after tumor resection
Fibula flap reconstruction surgery
Oral squamous cell carcinoma patients received the reconstruction with fibula flaps after tumor resection
Thoracodorsal artery perforator flap group
Oral squamous cell carcinoma patients received the reconstruction with Thoracodorsal artery perforator flaps after tumor resection
Thoracodorsal artery perforator flap reconstruction surgery
Oral squamous cell carcinoma patients underwent reconstruction with thoracodorsal artery perforator (TDAP) flaps following tumor resection.
Interventions
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Thoracodorsal artery perforator flap reconstruction surgery
Oral squamous cell carcinoma patients underwent reconstruction with thoracodorsal artery perforator (TDAP) flaps following tumor resection.
Forearm flaps reconstruction surgery
Oral squamous cell carcinoma patients received the reconstruction with forearm flaps after tumor resection
Anterolateral thigh flap reconstruction surgery
Oral squamous cell carcinoma patients received the reconstruction with anterolateral thigh flaps after tumor resection
Fibula flap reconstruction surgery
Oral squamous cell carcinoma patients received the reconstruction with fibula flaps after tumor resection
Forearm flap reconstruction surgery
Oral squamous cell carcinoma patients received the reconstruction with forearm flaps after tumor resection
Eligibility Criteria
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Inclusion Criteria
2. Preoperative pathological biopsy confirmed as oral squamous cell carcinoma.
3. Patients with oral squamous cell carcinoma who have completed comprehensive laboratory tests before surgery.
4. Patients with oral squamous cell carcinoma who underwent tumor resection and flap reconstruction at our hospital.
5. Postoperative pathological diagnosis confirmed as oral squamous cell carcinoma.
6. Patients with oral squamous cell carcinoma who attend follow-up visits at 1, 3, 6, and 12 months post-surgery, completing all clinical examinations and questionnaires.
Exclusion Criteria
2. Patients with oral squamous cell carcinoma who have incomplete laboratory test results from our hospital.
3. Patients with oral squamous cell carcinoma with postoperative pathology that remains unclear or cannot be confirmed as oral squamous cell carcinoma.
4. Patients with oral squamous cell carcinoma who are unable to attend follow-up visits at 1, 3, 6, and 12 months.
5. Patients who do not complete the questionnaires as required during follow-up visits.
18 Years
ALL
No
Sponsors
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Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
OTHER
Responsible Party
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Locations
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Sun Yat-sen Memorial Hospital, Sun Yat-sen Univerity
Guangzhou, Guangdong, China
Countries
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Central Contacts
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Facility Contacts
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References
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Min F, Qiu P, Zhu X, Zhou B, Lin Z, Pan C, Wang Y. Modified submandibular mandibulotomy approach versus lip-splitting approach in tongue cancer surgery: a retrospective paired-cohort study. Clin Oral Investig. 2023 Dec 26;28(1):32. doi: 10.1007/s00784-023-05395-3.
Zhou B, Liao J, Zhu C, Yuan K, Liu Z, Lin Z, Huang Z, Chen W, Li J, Wang Y. Full cheek defect reconstruction using ALTF versus RFF: Comparison of quality of life, clinical results, and donor site morbidity. Oral Dis. 2020 Sep;26(6):1157-1164. doi: 10.1111/odi.13354. Epub 2020 May 4.
Other Identifiers
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SYSKY-2024-710-01
Identifier Type: -
Identifier Source: org_study_id
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