For Patients with Stones in Gallbladder and Bile Duct Stones At the Same Time, Surgical Removal of the Gallbladder with the Laparoscope is Done in the Same Admission Compared to Its Removal After 6 Weeks Following Successful Removel of the Stones from the Bile Ducts by the Side View Endoscope

NCT ID: NCT06599437

Last Updated: 2024-09-19

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

50 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-12-01

Study Completion Date

2024-08-15

Brief Summary

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The goal of this clinical trial is to learn if early laparoscopic cholecystectomy is safe and feasible when performed during the same admission for patients with concomitant gallbladder and common bile duct stones after clearance of CBD stones via ERCP in comparison to Late laparoscopic cholecystectomy 6 weeks after ERCP. The main questions it aims to answer are: laparoscopic cholecystectomy

* Does index laparoscopic cholecystectomy associate with less recurrence of biliary complications?
* Is index laparoscopic cholecystectomy feasible and safe for the patients in terms of intraoperative difficulties, conversion to open, hospital stay, and postoperative complications than late laparoscopic cholecystectomy? the investigator will compare index laparoscopic cholecystectomy with late laparoscopic cholecystectomy 6 weeks after ERCP to see if index laparoscopic cholecystectomy is safe and feasible and associated with better outcomes.

Participants will:

Come to the outpatient clinic every week after intervention for follow-up for 3 months after surgery.

Detailed Description

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The study population of this randomized controlled trial study is those who underwent CBD stone clearance by ERCP. The included fifty patients were stratified randomly into two groups: early and delayed.

Randomization was done using computer-generated random number sequences in concealed envelopes with a block randomization design. Laparoscopic cholecystectomy is performed on the next day after successful clearance of stones from CBD while, the patient is still admitted, for the early group and postponed 4 to 6 weeks for the delayed group after the patient is discharged home.

Laparoscopic cholecystectomy was performed by the same surgical team for both groups.

Conditions

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Choledocholithiasis with Cholecystitis

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Participants

Study Groups

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Early same admission laparoscopic cholecystectomy ( group A)

Early laparoscopic cholecystectomy is performed on next day within 24 hours after common bile duct stone removal by ERCP.

Group Type ACTIVE_COMPARATOR

laparoscopic cholecystectomy

Intervention Type PROCEDURE

Early laparoscopic cholecystectomy in the same admission after atone clearance from the bile ducts via ERCP.

Late laparoscopic cholecystectomy ( group B)

Late laparoscopic cholecystectomy is performed 6 weeks after common bile duct stones clearance

Group Type ACTIVE_COMPARATOR

Late laparoscopic cholecystectomy

Intervention Type PROCEDURE

Laparoscopic cholecystectomy is performed 6 weeks after clearance of stones from the common bile duct.

Interventions

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laparoscopic cholecystectomy

Early laparoscopic cholecystectomy in the same admission after atone clearance from the bile ducts via ERCP.

Intervention Type PROCEDURE

Late laparoscopic cholecystectomy

Laparoscopic cholecystectomy is performed 6 weeks after clearance of stones from the common bile duct.

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Patients with concomitant gallbladder and common bile duct stone who underwent clearance of common bile duct stones by ERCP

Exclusion Criteria

* Severe pancreatitis
* Suspicion of post-ERCP bleeding or perforation,
* Associated malignancy
* Those in whom ERCP failed to clear the CBD stones
Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Damanhour Medical National Institute

OTHER_GOV

Sponsor Role lead

Responsible Party

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Wael Ahmed El-Dawy

Lecturer of Hepatopacreatobiliary and GI Surgery

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Damanhur Medical National Institute

Damanhur, Behira, Egypt

Site Status

Countries

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Egypt

Other Identifiers

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HD000192

Identifier Type: -

Identifier Source: org_study_id

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