Single Port Versus Four Ports Laparoscopic Cholecystectomy and Early Postoperative Pain

NCT ID: NCT01268748

Last Updated: 2010-12-31

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

120 participants

Study Classification

INTERVENTIONAL

Study Start Date

2010-09-30

Study Completion Date

2012-06-30

Brief Summary

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This is a trial to evaluate if single port laparoscopic cholecystectomy causes less pain than conventional laparoscopic cholecystectomy.

Detailed Description

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This study is a randomized, two-arm, double-blinded three-center trial to compare single-port transumbilical laparoscopic cholecystectomy with conventional 4-port laparoscopic cholecystectomy. 120 patients are included with a 1:1 randomization. Three centers participate in the trial.

Inclusion criteria: Female patients, ASA I-III, age between 18 and 75 years, elective laparoscopic cholecystectomy because of biliary pain or recent uncomplicated biliary pancreatitis.

Exclusion criteria: Expected poor compliance, history of cholecystitis or severe pancreatitis, previous open upper abdominal surgery, pregnancy or lactation, preoperative chronic pain or conversion from laparoscopic to open surgery.

Pain and nausea is measured on VAS before the operation and 3 hrs, 1 day, 2 days and 3 days after the operation.

Cosmesis is evaluated after 28 days.

Patients are telephone-interviewed after 12 months and asked about port hernia formation. If hernia is suspected patients are called in for an abdominal ultrasonography.

Conditions

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Pain, Postoperative Postoperative Nausea and Vomiting Postoperative Complications

Keywords

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single site surgery laparoscopic surgery pain nausea

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

TRIPLE

Participants Caregivers Outcome Assessors

Study Groups

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4 ports laparoscopic cholecystectomy

Group Type OTHER

Conventional laparoscopic procedure

Intervention Type PROCEDURE

Patients allocated to this group will undergo laparoscopic cholecystectomy using two 12 mm ports and two 5 mm ports

One port transumb. laparoscopic surgery

Group Type OTHER

Experimental laparoscopic procedure

Intervention Type PROCEDURE

Patients allocated to this group will undergo laparoscopic cholecystectomy using only a transumbilical SILS port

Interventions

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Conventional laparoscopic procedure

Patients allocated to this group will undergo laparoscopic cholecystectomy using two 12 mm ports and two 5 mm ports

Intervention Type PROCEDURE

Experimental laparoscopic procedure

Patients allocated to this group will undergo laparoscopic cholecystectomy using only a transumbilical SILS port

Intervention Type PROCEDURE

Other Intervention Names

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Versaport 12 mm Versaport 5 mm SILS port

Eligibility Criteria

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Inclusion Criteria

* ASA I-III
* Planned elective laparoscopic cholecystectomy because of biliary pain or uncomplicated biliary pancreatitis

Exclusion Criteria

* Expected poor compliance
* History of cholecystitis or severe pancreatitis
* Earlier open upper abdominal surgery, pregnancy or lactation, chronic pain or conversion to open surgery
Minimum Eligible Age

18 Years

Maximum Eligible Age

75 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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University Hospital, Gentofte, Copenhagen

OTHER

Sponsor Role collaborator

University of Copenhagen

OTHER

Sponsor Role collaborator

Bispebjerg Hospital

OTHER

Sponsor Role lead

Responsible Party

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Dept. of Surgery K, Bispebjerg Hospital, University of Copenhagen, DK-2400 Copenhagen NV, Denmark

Principal Investigators

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Haytham Al-Tayar, MD

Role: PRINCIPAL_INVESTIGATOR

Dept. of Surgery, Bispebjerg Hospital, University of Copenhagen

Sami Assaadzadeh, MD

Role: PRINCIPAL_INVESTIGATOR

Dept. of Surgery, Gentofte Hospital, University of Copenhagen

Jacob Rosenberg, MD, DrMSc

Role: PRINCIPAL_INVESTIGATOR

Dept. of Surgery, Herlev Hospital, University of Copenhagen

Flemming Hjørne, MD

Role: PRINCIPAL_INVESTIGATOR

Dept. of Surgery, Køge Hospital, University of Copenhagen

Thue Bisgaard, MD, DrMSc

Role: PRINCIPAL_INVESTIGATOR

Dept. of Surgery, Køge Hospital, University of Copenhagen

Locations

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Dept. of Surgery K, Bispebjerg Hospital

Copenhagen NV, , Denmark

Site Status RECRUITING

Gentofte Hospital, University of Copenhagen

Gentofte Municipality, , Denmark

Site Status RECRUITING

Dept. of Surgery, Koege Hospital, University of Copenhagen

Koege, , Denmark

Site Status RECRUITING

Countries

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Denmark

Central Contacts

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Lars N Jorgensen, MD, DrMSc

Role: CONTACT

Phone: +45 35316441

Email: [email protected]

Facility Contacts

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Lars N Jorgensen, MD, DrMSc

Role: primary

Jacob Rosenberg, MD, DrMSc

Role: primary

Thue Bisgaard, MD, DrMSc

Role: primary

References

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Jorgensen LN, Rosenberg J, Al-Tayar H, Assaadzadeh S, Helgstrand F, Bisgaard T. Randomized clinical trial of single- versus multi-incision laparoscopic cholecystectomy. Br J Surg. 2014 Mar;101(4):347-55. doi: 10.1002/bjs.9393.

Reference Type DERIVED
PMID: 24536008 (View on PubMed)

Other Identifiers

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H-3-2010-064

Identifier Type: -

Identifier Source: org_study_id