Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
200 participants
OBSERVATIONAL
2024-08-15
2026-06-01
Brief Summary
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Detailed Description
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Conditions
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Study Design
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CASE_CONTROL
PROSPECTIVE
Study Groups
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Males with aortic stenosis
Males with mild or greater aortic stenosis (aortic valve area \<1.5 cm2) due to calcific non-congenital aortic stenosis.
Blood analysis for loss-of-Y chromosome
Analysis for the percentage of circulating leukocytes with loss-of-y chromosome
Control males without aortic stenosis
Males without any diagnosis for aortic stenosis (matched for aortic stenosis group).
Blood analysis for loss-of-Y chromosome
Analysis for the percentage of circulating leukocytes with loss-of-y chromosome
Interventions
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Blood analysis for loss-of-Y chromosome
Analysis for the percentage of circulating leukocytes with loss-of-y chromosome
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* History of radiation to chest
* Inflammatory (autoimmune, rheumatologic) disease associated with aortic stenosis
* Active cancer
40 Years
MALE
Yes
Sponsors
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University of Virginia
OTHER
Responsible Party
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Jonathan Lindner, MD
Professor of Medicine
Locations
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University of Virginia
Charlottesville, Virginia, United States
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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301597
Identifier Type: -
Identifier Source: org_study_id
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