Evaluation of Nasal Elevator Versus Grayson's Nasal Stent with D-NAM Appliance on Nasolabial Esthetics in Bilateral Cleft Lip and Palate Infants

NCT ID: NCT06589453

Last Updated: 2024-10-17

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Clinical Phase

PHASE1

Total Enrollment

20 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-11-01

Study Completion Date

2026-10-01

Brief Summary

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Newborns with bilateral cleft lip/ palate will be treated pre-surgically by either nasal elevator or Grayson nasal stent in conjunction with digital nasoalveolar molding (D-NAM) appliance in order to evaluate their effect on the nasolabial esthetics.

Detailed Description

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The aim of this trial is to evaluate and compare the short-term effect of nasal elevator with Grayson nasal stent in conjunction with digital nasoalveolar molding appliances at 2 stages T1 (Before NAM therapy), and T2 (After NAM therapy) as regards nasolabial esthetics and maxillary arch changes.

Newborns with Bilateral cleft lip/ palate will be allocated randomly into two groups: the first group will receive nasal elevator with digital nasoalveolar molding appliance while the second group will receive Grayson nasal stent with digital nasoalveolar molding appliance. The follow-up period will be 4-6 months till surgical lip closure. The nasolabial esthetics will be assessed using facial scans and 2D photographs, while changes in the maxillary arch will be assessed by digital maxillary models.

Conditions

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Cleft Lip and Cleft Palate

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Outcome Assessors

Study Groups

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Nasal stent with Digital Nasoalveolar molding

Group Type ACTIVE_COMPARATOR

Nasal stent with digital nasoalveolar molding in bilateral cleft lip and palate infants

Intervention Type DEVICE

Nasal stent that is used in conjunction with digital nasoalveolar molding in bilateral cleft lip and palate infants

Nasal elevator with Digital Nasoalveolar molding

Nasal elevator will be used in conjunction with digital nasoalveolar molding appliance to improve nasolabial esthetics in bilateral cleft lip and palate infants.

Group Type EXPERIMENTAL

Nasal elevator with digital nasoalveolar molding in bilateral cleft lip and palate infants

Intervention Type DEVICE

This is a unique nasal elevator aiming to improve nasolabial esthetics in conjunction with digital nasoalveolar molding appliance when used in bilateral cleft lip and palate infants.

Interventions

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Nasal elevator with digital nasoalveolar molding in bilateral cleft lip and palate infants

This is a unique nasal elevator aiming to improve nasolabial esthetics in conjunction with digital nasoalveolar molding appliance when used in bilateral cleft lip and palate infants.

Intervention Type DEVICE

Nasal stent with digital nasoalveolar molding in bilateral cleft lip and palate infants

Nasal stent that is used in conjunction with digital nasoalveolar molding in bilateral cleft lip and palate infants

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Non-syndromic Infants with complete BCLP infants
* Infants less than 1 month of age.
* Males and females.
* Infants with displaced premaxilla
* Patients whose parents provided written consent for the study.

Exclusion Criteria

* Patients above 1 month of age.
* Syndromic and systemically ill infants.
* Patients with unilateral cleft lip and palate.
* Incomplete Cleft lip or Simonart band (soft tissue bridge at the cleft side).
* Medically compromised patients
* Patien parents/guardians who will be unwilling to go through the Naso-alveolar molding (NAM) therapy.
Minimum Eligible Age

1 Day

Maximum Eligible Age

1 Month

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Cairo University

OTHER

Sponsor Role lead

Responsible Party

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: Donia Ayman Ahmed Ezzeldin ElSayed

Assistant lecturer at Orthodontic Department, Cairo University

Responsibility Role PRINCIPAL_INVESTIGATOR

Central Contacts

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Donia Ayman Ahmed Ezzeldin, PhD

Role: CONTACT

00201001200089

Mohamed Abd-El-Ghafour Omar

Role: CONTACT

00201007433288

Other Identifiers

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D-NAM 2024

Identifier Type: -

Identifier Source: org_study_id

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