Effectiveness and Safety of Adjuvant Software Based on Virtual Reality for Post-thoracoscopic Surgery Pain

NCT ID: NCT06574451

Last Updated: 2024-08-28

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

215 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-04-22

Study Completion Date

2025-04-24

Brief Summary

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A randomized controlled, prospective, multicenter, open label, superiority trial aims to evaluate the effectiveness and safety of adjuvant software based on virtual reality for post-thoracoscopic surgery pain.

Detailed Description

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215 eligible patients will be enrolled. All enrolled patients will have an NRS score at 24 hours postoperatively, and those with a score greater than or equal to 4 will be randomly assigned to the test and control groups.

Patients in the experimental group will receive postoperative analgesic adjunctive therapy software to assist in pain control, with one postoperative analgesic adjunctive therapy software intervention at 24 hours and 48 hours after surgery, and pain evaluation within 30 minutes.

The control group will not experience postoperative analgesic adjuvant therapy software and will only record the pain level within 30 minutes. Subjects will complete a study summary form upon completion of follow-up.

All participants will receive intravenous analgesics pumped with mechanical pumps (analgesic pumps: Flurbiprofen cilexil Injection 5ml: 50mg/stick\*4 sticks, combined with Dezocine Injection 1ml: 5mg/stick\*6 sticks, add Ondansetron Hydrochloride Injection: 2ml: 4mg/stick\*2 sticks; or add Tolisetron Mesylate Injection: 2ml: 6 mg/stick\*4 sticks, diluted to 100mL with 0.9% sodium chloride injection).In case of an outbreak of pain (when analgesic pump is ineffective and the pain is unbearable), analgesic medication regimen: flurbiprofen cilofen injection (5 ml): 50 mg/piece, intravenous injection.

Conditions

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Acute Postoperative Pain Video-assisted Thoracic Surgery Virtual Reality

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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VR-assisted postoperative analgesia group

Patients will receive postoperative analgesic adjunctive therapy software to assist in pain control, with one postoperative analgesic adjunctive therapy software intervention at 24 hours and 48 hours after surgery, and pain evaluation within 30 minutes.

All participants will receive intravenous analgesics pumped with mechanical pumps (analgesic pumps: Flurbiprofen cilexil Injection 5ml: 50mg/stick\*4 sticks, combined with Dezocine Injection 1ml: 5mg/stick\*6 sticks, add Ondansetron Hydrochloride Injection: 2ml: 4mg/stick\*2 sticks; or add Tolisetron Mesylate Injection: 2ml: 6 mg/stick\*4 sticks, diluted to 100mL with 0.9% sodium chloride injection).In case of an outbreak of pain (when analgesic pump is ineffective and the pain is unbearable), analgesic medication regimen: flurbiprofen cilofen injection 5 ml: 50 mg/piece, intravenous injection.

Group Type EXPERIMENTAL

VR-assisted postoperative analgesia

Intervention Type DEVICE

Patients will receive postoperative analgesic adjunctive therapy software to assist in pain control, with one postoperative analgesic adjunctive therapy software intervention at 24 hours and 48 hours after surgery, and pain evaluation within 30 minutes.

Non-VR-assisted analgesia group

The control group will not experience postoperative analgesic adjuvant therapy software and will only record the pain level within 30 minutes at 24 hours and 48 hours after surgery.

All participants will receive intravenous analgesics pumped with mechanical pumps (analgesic pumps: Flurbiprofen cilexil Injection 5ml: 50mg/stick\*4 sticks, combined with Dezocine Injection 1ml: 5mg/stick\*6 sticks, add Ondansetron Hydrochloride Injection: 2ml: 4mg/stick\*2 sticks; or add Tolisetron Mesylate Injection: 2ml: 6 mg/stick\*4 sticks, diluted to 100mL with 0.9% sodium chloride injection).In case of an outbreak of pain (when analgesic pump is ineffective and the pain is unbearable), analgesic medication regimen: flurbiprofen cilofen injection 5 ml: 50 mg/piece, intravenous injection.

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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VR-assisted postoperative analgesia

Patients will receive postoperative analgesic adjunctive therapy software to assist in pain control, with one postoperative analgesic adjunctive therapy software intervention at 24 hours and 48 hours after surgery, and pain evaluation within 30 minutes.

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* 1.Age greater than or equal to 18 years.

2.Patients within 1 day after thoracoscopic surgery.

3.Junior high school degree or above, Mandarin communication is unimpeded, with certain Internet knowledge and mobile phone reading and writing skills.

4.The score of the numeric grading scale (NRS) at 24 hours postoperatively ≥ 4 points.

5.Patients who are able to understand the purpose of the study, voluntarily participate in and sign the informed consent form, and are willing to complete the follow-up as required by the protocol.

Exclusion Criteria

* 1.Patients with severe cognitive impairment.

2.Patients with a previous diagnosis of epilepsy, dementia, migraine, or other neurological disease that may result in the inability to use postoperative analgesic adjuvant therapy software or that may have adverse effects.

3.Patients who are unable to understand or speak Mandarin.

4.Patients who have visual abnormalities, severe hearing impairment, or motion sickness, etc., and are unable to view VR.

5.Patients with trauma to the eyes, face, or neck that prevents the comfortable use of the VR device.

6.Patients with severe heart, liver, kidney, hematologic, digestive, nervous system diseases and malnutrition.

7.Patients who have previously used virtual reality software for pain that has not responded to treatment.

8.Patients with a history of severe alcohol abuse, long-term heavy drinking, and symptoms of alcohol dependence.

9.Patients who have participated in any analgesic interventional study within the past 1 week.

10.Females who are pregnant or plan to become pregnant during the study.

11.The patient or their immediate family member works for a digital health or pharmaceutical company for acute or chronic pain treatment.

12.Patients who are unable to use electronic devices such as smartphones.

13.Other conditions that the investigator considers inappropriate for participation in a clinical trial.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Guang Dong Liang Zi Health Consulting Co., Ltd, Guang Dong, China.

UNKNOWN

Sponsor Role collaborator

Tianjin Medical University General Hospital

OTHER

Sponsor Role collaborator

Ruijin Hospital

OTHER

Sponsor Role collaborator

Maoming People's Hospital

OTHER

Sponsor Role collaborator

Guangdong Provincial People's Hospital

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Wen-Zhao Zhong

Role: PRINCIPAL_INVESTIGATOR

Guangdong Provincial People's Hospital

Locations

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Guangdong Lung Cancer Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences

Guangzhou, Guangdong, China

Site Status RECRUITING

Maoming People's Hospital

Maoming, Guangdong, China

Site Status RECRUITING

Ruijing Hospital, Shanghai Jiao Tong University

Shanghai, Shanghai Municipality, China

Site Status RECRUITING

Tianjin Medical University General Hospital

Tianjin, Tianjin Municipality, China

Site Status RECRUITING

Countries

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China

Central Contacts

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Wen-Zhao Zhong

Role: CONTACT

+86-13609777314

Ben-Yuan Jiang

Role: CONTACT

+86-18613025014

Facility Contacts

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Wen-zhao Zhong, PhD

Role: primary

+86 20 83827812 ext. 51221

Ben-Yuan Jiang, PhD

Role: backup

+8618613025014

Zhi-Qiang Luo

Role: primary

Xiao-Yang Su

Role: backup

He-Cheng Li, PhD

Role: primary

Guo Wei

Role: backup

Song Xu, PhD

Role: primary

Fan Ren, PhD

Role: backup

Other Identifiers

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VR-TSP

Identifier Type: -

Identifier Source: org_study_id

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