Efficacy and Safety of JAK Inhibitors in Patients With AA: RWE Study

NCT ID: NCT06573593

Last Updated: 2024-08-27

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

RECRUITING

Total Enrollment

150 participants

Study Classification

OBSERVATIONAL

Study Start Date

2024-07-29

Study Completion Date

2026-12-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The introduction of Janus Kinase inhibitors (JAKi) seems to revolutionize the field of alopecia areata (AA) therapeutics. However, the ideal JAKi is not yet settled and the real-world data are still missing. To provide evidence about effectiveness and safety of different JAKi including tofacitinib, baricitinib, ritlecitinib,abrocitinib, upadacitinib and ifidancitinib in real-world settings and describe baseline disease characteristics and patients profiles that are considered good candidates for JAKi in the daily practice. Furthermore, we intended to investigate the efficacy and safety of JAK Inhibitors in patients With AA, as well as to provide clinical evidence for the clinicians and patients when they formulate individualized treatment plans.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Alopecia Areata Janus Kinase Inhibitors

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Tofacitinib treated group

In the real-world settings, patients with AA treated with tofacitinib.

Tofacitinib

Intervention Type DRUG

In the real-world settings, patients with AA treated with tofacitinib.

Baritinib treated group

In the real-world settings, patients with AA treated with baritinib.

Baricitinib

Intervention Type DRUG

In the real-world settings, patients with AA treated with Baricitinib.

Ruxolitinib treated group

In the real-world settings, patients with AA treated with ruxolitinib

Ruxolitinib

Intervention Type DRUG

In the real-world settings, patients with AA treated with Ruxolitinib.

Upadacitinib treated group

In the real-world settings, patients with AA treated with upadacitinib.

Upadacitinib

Intervention Type DRUG

In the real-world settings, patients with AA treated with Upadacitinib.

Abrocitinib treated group

In the real-world settings, patients with AA treated with abhicitinib.

Abrocitinib

Intervention Type DRUG

In the real-world settings, patients with AA treated with Abrocitinib.

Ritlecitinib treated group

In the real-world settings, patients with AA treated with ritlecitinib.

Ritlecitinib

Intervention Type DRUG

In the real-world settings, patients with AA treated with Ritlecitinib.

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Tofacitinib

In the real-world settings, patients with AA treated with tofacitinib.

Intervention Type DRUG

Baricitinib

In the real-world settings, patients with AA treated with Baricitinib.

Intervention Type DRUG

Ruxolitinib

In the real-world settings, patients with AA treated with Ruxolitinib.

Intervention Type DRUG

Upadacitinib

In the real-world settings, patients with AA treated with Upadacitinib.

Intervention Type DRUG

Abrocitinib

In the real-world settings, patients with AA treated with Abrocitinib.

Intervention Type DRUG

Ritlecitinib

In the real-world settings, patients with AA treated with Ritlecitinib.

Intervention Type DRUG

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Patients with alopecia areata between 2 to 18 years old
* Patients diagnosed with alopecia areata according to AA guideline
* AA Patients treated with JAKi including tofacitinib, baricitinib, ritlecitinib,abrocitinib, upadacitinib and ifidancitinib for more than 3 months

Exclusion Criteria

* Patients had previously received hair implants
* Other alopecia
* Other diseases may induce alopecia including psoriasis, lichen planus, et al.
* Unable to estimate SALT score at baseline or at follow-up
* Patients are participating in other clinical trials
Minimum Eligible Age

2 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Second Affiliated Hospital, School of Medicine, Zhejiang University

OTHER

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Responsibility Role SPONSOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Xianjie Wu, Ph.D

Role: PRINCIPAL_INVESTIGATOR

Second Affiliated Hospital, School of Medicine, Zhejiang University

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Second Affiliated Hospital, School of Medicine, Zhejiang University, China

Hangzhou, Zhejiang, China

Site Status RECRUITING

Countries

Review the countries where the study has at least one active or historical site.

China

Central Contacts

Reach out to these primary contacts for questions about participation or study logistics.

Ru Dai, MD

Role: CONTACT

15982215914

Wu

Role: CONTACT

Facility Contacts

Find local site contact details for specific facilities participating in the trial.

Ru Dai, Ph.D

Role: primary

86 15982215914

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

20240699

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.