Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
600 participants
OBSERVATIONAL
2024-03-18
2028-12-31
Brief Summary
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Detailed Description
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Tear fluid is collected using Shirmer's test. Dried blood spots are obtained by a small prick in the finger with a lancet. The blood droplet is transferred onto a special piece of filter paper, where it dries.
As a sub-study, participants who have provided written consent specifically for this purpose will repeat the test with dried blood spots at home one week after participating in the study. The samples are submitted to the Memory Clinic at the participant's next scheduled appointment.
Tear fluid, dried blood spots, as well as blood and cerebrospinal fluid will be examined for AD-related pathology.
Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Alzheimer's disease
Patients diagnosed with Alzheimer's disease (AD), either MCI, mild or moderate dementia.
No interventions assigned to this group
Cognitive impairment due to non-Alzheimer's disease
Patients diagnosed with one of the following dementia disorders: Dementia with Lewy Bodies (DLB), Frontotemporal dementia (FTD), vascular dementia (VaD) and Normal pressure hydrocephalus (NPH).
No interventions assigned to this group
Controls
Patients who have undergone a diagnostic work-up in a memory clinic, but no neurodegenerative or other neurological disease was found, serve as control group.
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* Diagnosis of Alzheimer's disease, Dementia with Lewy Bodies (DLB), Frontotemporal dementia (FTD), vascular dementia (VaD) or Normal pressure hydrocephalus (NPH)
* Of legal age.
* Lumbar puncture with CSF avaiable for analysis
* No neurological disease.
* Of legal age.
Exclusion Criteria
* Clinically assessed as unfit to participate in the project.
30 Years
ALL
No
Sponsors
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Danish Dementia Research Centre
NETWORK
Responsible Party
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Locations
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Danish Dementia Research Centre
Copenhagen, , Denmark
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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H-23078392
Identifier Type: -
Identifier Source: org_study_id
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