Integrated Case Management for Burns Care in Pakistan

NCT ID: NCT06559501

Last Updated: 2025-07-30

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

1146 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-09-02

Study Completion Date

2026-10-31

Brief Summary

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To test whether a culturally adapted multicomponent intervention for improving burns care and patient/family rehabilitation is effective in improving survival among burn victims in Pakistan and is cost-effective. The comparator will be usual care plus brief written self-help advice (enhanced usual care). The study is designed as a multicentre, pragmatic, parallel group, individually randomised trial. Participants in the intervention arm will receive 8 sessions delivered by the case managers (6 low-intensity sessions lasting 30-60 minutes in the hospital/community and 2 follow-up sessions lasting 30 minutes in the community). Assessments will be conducted at baseline, at 3 months, 6 months and at 12-months post-intervention.

Detailed Description

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The Burns trial will be conducted in six cities of Pakistan; Karachi, Hyderabad, Lahore, Rawalpindi, Peshawar and Quetta to compare integrated intervention with enhanced usual care. Participants will be randomized either to the intervention or enhanced usual care. The intervention consists of multiple culturally adapted components such as psychological bundle, emergency care, surgical and rehab bundle to improve care within burn units, transitional care, and patient and family rehabilitation (known as 'Integrated case management for improved psychosocial and physical rehabilitation of burn survivors and their families'). The comparator will be usual care (emergency, surgical and rehab care ) plus brief written self-help booklets will be given(enhanced usual care).

The intervention will be carried out by case managers (trained allied health professionals such as nurses, physiotherapists, psychologists etc) and will be started during hospital stay to enhance physical health outcomes by educating patients about self-care/ medications and adherence to treatment resources provided to the case managers and upon discharge to the participants and their carers.

Participants in the intervention arm will receive 8 sessions delivered by the case managers (6 low-intensity sessions lasting 30-60 minutes in the hospital/community and 2 follow-up sessions lasting 30 minutes in the community). Assessments will be conducted at baseline, at 3 months, 6 months and at 12-months post-intervention.

Conditions

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Unintentional Burn Injury Depression Anxiety Burns

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

SUPPORTIVE_CARE

Blinding Strategy

DOUBLE

Investigators Outcome Assessors

Study Groups

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Integrated case manager care

comprises 8 sessions delivered by case managers. Case managers will provide up to 6 low-intensity sessions in the hospital or the community (if the patient is discharged before completing the required sessions), with content and duration tailored to patient preferences. Post-discharge, patients will receive 2 follow-up sessions with case managers to ensure a smooth transition into the community.

Group Type EXPERIMENTAL

Integrated case manager care

Intervention Type BEHAVIORAL

comprises 8 sessions delivered by case managers. Case managers will provide up to 6 low-intensity sessions in the hospital or the community (if the patient is discharged before completing the required sessions), with content and duration tailored to patient preferences. Post-discharge, patients will receive 2 follow-up sessions with case managers to ensure a smooth transition into the community.

Enhanced care as usual

includes their standard care, and all treatments recommended by attending physicians will be provided, plus a written self-help booklet

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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Integrated case manager care

comprises 8 sessions delivered by case managers. Case managers will provide up to 6 low-intensity sessions in the hospital or the community (if the patient is discharged before completing the required sessions), with content and duration tailored to patient preferences. Post-discharge, patients will receive 2 follow-up sessions with case managers to ensure a smooth transition into the community.

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Adults 18 years and over
* Accidental burn injury and meet the criteria for admission to burn centres
* Clinician judgment for participation readiness
* Ability to provide informed consent

Exclusion Criteria

No intentional burn injuries

• Lacking capacity to provide informed consent
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of Manchester

OTHER

Sponsor Role collaborator

Pakistan Institute of Living and Learning

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Nasim Chaudhry, MD

Role: PRINCIPAL_INVESTIGATOR

Pakistan Institute of Living and Learning

Locations

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Burn Unit, Sandeman Provisional Hospital

Quetta, Balochistan, Pakistan

Site Status RECRUITING

Plastic Surgery and Burn Unit, BMC, Quetta

Quetta, Balochistan, Pakistan

Site Status RECRUITING

Burns and Plastic Surgery Center, Peshawar

Peshawar, KPK, Pakistan

Site Status RECRUITING

Department of Plastic, Reconstructive Surgery and Burn Unit, Kind Edward Medical University

Lahore, Punjab Province, Pakistan

Site Status RECRUITING

Jinnah Burn & Reconstructive Surgery Centre, Lahore

Lahore, Punjab Province, Pakistan

Site Status RECRUITING

Pak Italian Modern Burn and Plastic Surgery Centre

Multan Khurd, Punjab Province, Pakistan

Site Status RECRUITING

Burn Centre, Civil Hospital Hyderabad

Hyderābād, Sindh, Pakistan

Site Status RECRUITING

Burn Centre, Ruth K. M. Pfau, Civil Hospital Karachi

Karachi, Sindh, Pakistan

Site Status RECRUITING

Burns and Plastic Surgery, Patel Hospital, Karachi

Karachi, Sindh, Pakistan

Site Status RECRUITING

Allied Burn & Reconstructive Surgery Centre

Faisalābad, , Pakistan

Site Status RECRUITING

Burn Care Centre, PIMS, Islamabad

Islamabad, , Pakistan

Site Status RECRUITING

Countries

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Pakistan

Central Contacts

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Ameer Khoso, PhD Fellow

Role: CONTACT

+92-2135871845

sehrish Tofique, PhD Fellow

Role: CONTACT

+92-2135871845

Facility Contacts

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Dr Silsila Sherzad, MBBS

Role: primary

Irfan Ullah

Role: primary

Mustehsan Bashir

Role: primary

Farrukh Aslam, FCPS

Role: primary

Saadia Rasheed

Role: primary

Samia Tasleem

Role: primary

Mazhar Nizam, FCPS

Role: primary

Urwa Ahmed

Role: primary

Rehan Ahmed, MBBS

Role: primary

References

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Kroenke K, Spitzer RL, Williams JB. The PHQ-9: validity of a brief depression severity measure. J Gen Intern Med. 2001 Sep;16(9):606-13. doi: 10.1046/j.1525-1497.2001.016009606.x.

Reference Type BACKGROUND
PMID: 11556941 (View on PubMed)

Blades B, Mellis N, Munster AM. A burn specific health scale. J Trauma. 1982 Oct;22(10):872-5. doi: 10.1097/00005373-198210000-00012.

Reference Type BACKGROUND
PMID: 7131607 (View on PubMed)

Spitzer RL, Kroenke K, Williams JB, Lowe B. A brief measure for assessing generalized anxiety disorder: the GAD-7. Arch Intern Med. 2006 May 22;166(10):1092-7. doi: 10.1001/archinte.166.10.1092.

Reference Type BACKGROUND
PMID: 16717171 (View on PubMed)

Herdman M, Gudex C, Lloyd A, Janssen M, Kind P, Parkin D, Bonsel G, Badia X. Development and preliminary testing of the new five-level version of EQ-5D (EQ-5D-5L). Qual Life Res. 2011 Dec;20(10):1727-36. doi: 10.1007/s11136-011-9903-x. Epub 2011 Apr 9.

Reference Type BACKGROUND
PMID: 21479777 (View on PubMed)

Rosenberg M. Rosenberg self-esteem scale. Journal of Religion and Health. 1965

Reference Type BACKGROUND

Langley GB, Sheppeard H. The visual analogue scale: its use in pain measurement. Rheumatol Int. 1985;5(4):145-8. doi: 10.1007/BF00541514.

Reference Type BACKGROUND
PMID: 4048757 (View on PubMed)

Cloitre M, Shevlin M, Brewin CR, Bisson JI, Roberts NP, Maercker A, Karatzias T, Hyland P. The International Trauma Questionnaire: development of a self-report measure of ICD-11 PTSD and complex PTSD. Acta Psychiatr Scand. 2018 Dec;138(6):536-546. doi: 10.1111/acps.12956. Epub 2018 Sep 3.

Reference Type BACKGROUND
PMID: 30178492 (View on PubMed)

Lawrence JW, Fauerbach JA, Heinberg LJ, Doctor M, Thombs BD. The reliability and validity of the Perceived Stigmatization Questionnaire (PSQ) and the Social Comfort Questionnaire (SCQ) among an adult burn survivor sample. Psychol Assess. 2006 Mar;18(1):106-11. doi: 10.1037/1040-3590.18.1.106.

Reference Type BACKGROUND
PMID: 16594819 (View on PubMed)

Üstün TB. Measuring health and disability: Manual for WHO disability assessment schedule WHODAS 2.0: World Health Organization; 2010.

Reference Type BACKGROUND

Baryza MJ, Baryza GA. The Vancouver Scar Scale: an administration tool and its interrater reliability. J Burn Care Rehabil. 1995 Sep-Oct;16(5):535-8. doi: 10.1097/00004630-199509000-00013.

Reference Type BACKGROUND
PMID: 8537427 (View on PubMed)

Other Identifiers

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PILL-BURNS-OO1

Identifier Type: -

Identifier Source: org_study_id

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