Predictive Role of sTREM in Endovascular Thrombectomy Outcomes

NCT ID: NCT06545591

Last Updated: 2024-08-09

Basic Information

• Recruitment Status: RECRUITING
• Total Enrollment: 300 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2024-07-01
• Study Completion Date: 2027-12-31

Brief Summary

Soluble triggering receptor expressed on myeloid cells (sTREM), which reflects microglia activation, has been reported closely associated with neuronal injury and neuroinflammation. This study is to investigatethe prognostic roles of sTREM (sTREM1 and sTREM2) in patients with ischemic stroke who underwent endovascular thrombectomy (EVT).

Detailed Description

For acute ischemic stroke, the current treatment strategy involves timely recanalization by intravenous thrombolysis and endovascular thrombectomy (EVT). Patients receiving EVT are more likely to achieve successful revascularization and long--term functional independence compared with those receiving standard medical treatment.1 In patients receiving EVT, significant predictors of a favorable functional outcome include minor initial stroke severity, successful recanalization, and shorter onset--to--treatment time. However, unfavorable outcomes can occur even after early successful recanalization in some cases.Triggering receptors expressed on myeloid cells (TREM-1 and TREM-2) are a familyof receptors involved in the immune system expressed on a variety of innate cells of the myeloid lineage, including microglia. sTREM, which reflects microglia activation, has been reported closely associated with neuronal injury and neuroinflammation. We enrolled adult patients with stroke who received EVT, with blood sampling immediately before (T1) and after EVT (T2), and at 24 hours after EVT (T3). Non--stroke controls and patients with non--EVT stroke were also enrolled. The plasma concentration of sTREM1 and sTREM2 were analyzed by ELISA. The medical information, image findings and levels of plasma sTREM1 and sTREM2 were analyzed to clarify the association with poor functional outcome (modified Rankin Scale 4-6) at 3 months after stroke.

Conditions

Acute Ischemic Stroke

Study Design

• Observational Model Type: CASE_CONTROL
• Study Time Perspective: PROSPECTIVE

Study Groups

EVT-stroke group

Patients with ischemic stroke who received endovascular thrombectomy (EVT) treatment

No interventions assigned to this group

non--EVT stroke group

The non--EVT stroke group was composed of patients with ischemic stroke without endovascular thrombectomy (EVT) treatment during the same period

No interventions assigned to this group

non--stroke control group

The non--stroke control group was composed of randomly selected stroke--free, age--matched and sex--matched individuals recruited from the health examination center.

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

• Patients > 18 years old.
• Patients with acute large vessel occlusion within 24 hours of onset who will receive endovascular treatment.

Exclusion Criteria

• Impossibility of getting a blood sample.
• Impossibility of performing the test (Invalid results).
• Refusal to provide the informed consent by the patient/relative.

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

The Affiliated Hospital of Xuzhou Medical University

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

Department of Neurology

Xuzhou, Jiangsu, China

Site Status: RECRUITING

Countries

China

Central Contacts

Xingzhi Wang, MD

Role: CONTACT

wxz1220@126.com

0086-13852000759

Facility Contacts

Xingzhi Wang, MD

Role: primary

wxz1220@126.com

0086-13852000759

Other Identifiers

XYFY2024-KL335-01

Identifier Type: -

Identifier Source: org_study_id