Efficacy and Safety of Intrathecal Administration of Thiotepa in Combination With Methotrexate in Breast Cancer With Leptomeningeal Metastasis

NCT ID: NCT06543992

Last Updated: 2024-08-09

Basic Information

• Recruitment Status: RECRUITING
• Clinical Phase: PHASE2
• Total Enrollment: 22 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2024-07-13
• Study Completion Date: 2026-12-13

Brief Summary

Evaluate the efficacy and safety of Intrathecal Administration of Thiotepa in Combination with Methotrexate via the Ommaya Reservoir in Breast Cancer with Leptomeningeal Metastasis

Detailed Description

This was a II, single-arm, prospective, multicenter study designed to estimate the efficacy and safety of intrathecal administration of thiotepa in combination with methotrexate via the Ommaya Reservoir in breast cancer with leptomeningeal metastasis.

The primary end point was iORR [complete response (CR) + partial response (PR)] according to RANO-LM. Scoring based on radiographic assessment in leptomeningeal metastases . A composite score (total score) is calculated and compared with the baseline total score. A 25% worsening in the current score relative to baseline defines radiographic progressive disease. A 50% improvement in the current score defines a radiographic partial response. Resolution of all baseline radiographic abnormalities defines a complete response. All other situations define stable disease. The secondary end points were changes in iPFS, iDoR, ORR, PFS, OS, DoR and exploratory analysis of the relationship between molecular markers and therapeutic efficacy.

This study is planned to include 22 patients with leptomeningeal metastasis from breast cancer who meet the entry criteria.

Conditions

Leptomeningeal Metastasis of Breast Cancer

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Intrathecal chemotherapy group

Patients received intrathecal 15mg MTX combination with 10mg thiotepa twice a week for 2 weeks (4 injections) followed by monthly injections of 15mg MTX combination with 10mg thiotepa until an event that meets the criteria for termination occurs.

Group Type: EXPERIMENTAL

Intrathecal Administration of Thiotepa in Combination with Methotrexate via the Ommaya Reservoir

Intervention Type: DRUG

Patients received intrathecal 15mg MTX combination with 10mg thiotepa twice a week for 2 weeks (4 injections) followed by monthly injections of 15mg MTX combination with 10mg thiotepa until an event that meets the criteria for termination occurs.

Interventions

Intrathecal Administration of Thiotepa in Combination with Methotrexate via the Ommaya Reservoir

Patients received intrathecal 15mg MTX combination with 10mg thiotepa twice a week for 2 weeks (4 injections) followed by monthly injections of 15mg MTX combination with 10mg thiotepa until an event that meets the criteria for termination occurs.

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

1. Patient is an adult female ≥18 and ≤75 years old at the time of informed consent.

2. ECGO rating 0-3.

3. Histologically or cytologically confirmed breast cancer.

4. Cerebrospinal fluid cytology combined with central nervous system function and brain imaging demonstrated the diagnosis of breast cancer with meningeal metastases;

5. Patients can be implanted or have been implanted with Ommaya reservoirs;

6. Patient must have at least one measurable lesion (according to RECIST 1.1 criteria);

7. Postmenopausal or pre/perimenopausal female patients are eligible for enrolment; pre or perimenopausal female patients must be willing to receive LHRHa during the study period.

8. All patients were required to meet the following laboratory biochemical values prior to enrolment:

• Haematology: Hb ≥90 g/L, WBC ≥3.5×109/L, ANC ≥1.5×109/L, PLT ≥100×109/L;
• Liver function: for those without liver metastases, AST, ALT, ALP ≤2.5 times the upper limit of normal values, and ≤1.25 x the upper limit of normal values for total bilirubin; for those with liver metastases, AST, ALT, ALP ≤ 5 times the upper limit of normal value, and total bilirubin ≤ 1.5 x upper limit of normal value.

Exclusion Criteria

1. Patients with other malignant tumors, excluding basal cell carcinoma and carcinoma in situ

2. Patients with severe or uncontrolled systemic disease, including uncontrolled hypertension or active bleeding tendency

3. The investigator considers the patient unsuitable for entry into this study.

4. Patients with toxicity from prior therapy that has not returned to normal or NCI-CTCAE grade 5.0

5. Patients who have a drug allergy or metabolic disorder to the drugs in this regimen

6. Pregnant or lactating women (women of childbearing age must have had a negative pregnancy test within 14 days prior to the first dose; if positive, pregnancy must be ruled out by ultrasound).

7. Patients who are concurrently enrolled in other clinical studies

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 75 Years
• Eligible Sex: FEMALE
• Accepts Healthy Volunteers: No

Sponsors

The Affiliated Brain Hospital of Nanjing Medical University

OTHER_GOV

Sponsor Role: collaborator

The First Affiliated Hospital with Nanjing Medical University

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

Jiangsu Provincial People's Hospital

Nanjing, Jiangsu, China

Site Status: RECRUITING

Countries

China

Central Contacts

Wei Li, Ph.D

Role: CONTACT

real.lw@163.com

025-68307102

Facility Contacts

Wei Li, Ph.D

Role: primary

real.lw@163.com

25-68307102

Other Identifiers

Ommaya 01

Identifier Type: -

Identifier Source: org_study_id