Study of Stapokibart Injection in Patients With Allergic Rhinitis

NCT ID: NCT06525597

Last Updated: 2024-11-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

PHASE2

Total Enrollment

120 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-09-30

Study Completion Date

2025-10-30

Brief Summary

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This study is a Randomized, Double-blind, Placebo-controlled phase II clinical study evaluating the efficacy and safety of Stapokibart injection in patients with allergic rhinitis.

Detailed Description

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Allergic rhinitis (AR) is a non infectious chronic inflammatory disease of the nasal mucosa that is mainly mediated by immunoglobulin E (IgE) in atopic individuals exposed to allergens.

Conditions

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Allergic Rhinitis

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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Stapokibart Group

Stapokibart, subcutaneous, once every two weeks

Group Type EXPERIMENTAL

Stapokibart Injection

Intervention Type BIOLOGICAL

IL-4Rα monoclonal antibody

Placebo Group

Placebo, subcutaneous, once every two weeks

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DRUG

Placebo

Interventions

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Stapokibart Injection

IL-4Rα monoclonal antibody

Intervention Type BIOLOGICAL

Placebo

Placebo

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Able to understand the study and voluntarily sign the Informed consent form.
* Diagnosed Allergic Rhinitis according to the Criteria stated in the Chinese Guidelines for the Diagnosis and Treatment of Allergic Rhinitis (2022, Revised Edition).
* Subjects with asthma must be evaluated by the researcher as having a stable condition.
* Has a positive skin prick test (SPT) or positive antigen-specific serum immunoglobulin E (IgE).

Exclusion Criteria

* Use of anti-interleukin 4 receptor alpha subunit (IL-4Rα) monoclonal antibody, thymic stromal lymphopoietin (TSLP) monoclonal antibody, anti-IgE monoclonal antibody, other monoclonal antibodies, or other biologics within 10 weeks or 5 half-lives (whichever is longer) prior to the screening visit.
* Use of any investigational product within 4 weeks prior to the screening visit or planning to participate in other clinical studies during this study.
* Forced expiratory volume in 1 second (FEV1) ≤ 50% of the predicted value during the screening/run-in period.
* Have acute sinusitis, nasal infection, or upper respiratory tract infection at screening or within 2 weeks prior to screening.
* Have received a live-attenuated vaccine within 12 weeks prior to randomization or planning to receive one during the study.
Minimum Eligible Age

12 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Keymed Biosciences Co.Ltd

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Luo Zhang

Role: PRINCIPAL_INVESTIGATOR

Beijing Tong-Ren hospital

Locations

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Beijing Tongren Hospital, CMU

Beijing, Beijing Municipality, China

Site Status RECRUITING

Countries

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China

Central Contacts

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Qian Jia

Role: CONTACT

028-88610620

Facility Contacts

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Luo Zhang

Role: primary

Other Identifiers

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CM310-107101

Identifier Type: -

Identifier Source: org_study_id

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