Effectiveness and Safety of SpineCare Used in Conjunction With Spinal Realignment Therapy

NCT ID: NCT06519201

Last Updated: 2024-07-25

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

10 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-07-14

Study Completion Date

2023-11-20

Brief Summary

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* The goal of this study is to evaluate the safety and effectiveness of traction treatment using SpineCare Device.
* Research period: May 1, 2023 - November 30, 2023 (7 months)
* Research subjects

* Male/female between 19 and 70 years old
* Scoliosis patients: Scoliosis patients whose Cobb's angle is less than 15°\~39°
* Treatment method: Group that applied traction treatment using SpineCare (traction device) and group that applied traction treatment without using SpineCare (traction device)
* Treatment period: Treatment twice a week from the 1st to 3rd week from the start of treatment, treatment once a week from the 4th to 7th week, A total of 10 times (takes approximately 2 months)
* Treatment time: approximately 50 minutes

Detailed Description

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1. Introduction Idiopathic scoliosis (IS) is a condition characterized by an abnormal lateral curvature and rotational deformity of the vertebral column, typically presenting as either an S- or C-shaped curve in the vertebral column. IS leads to musculoskeletal asymmetry, culminating in morphological and geometric changes in the torso. It can result in numerous is-sues such as changes in posture, sensory impairment, balance and gait problems, limitations in physical activity, pain, body image disturbances, and challenges in social communication . The treatment approach for IS depends on the severity of the curve measured by Cobb's angle: surgical intervention is considered for angles of 40º or greater, while non-surgical treatments are considered for angles under 40º. Non-surgical modalities include physical therapy, manipulative therapy, braces, and exercise therapy. Traditionally, braces are recommended for Cobb's angles of 20-40º. However, braces often lead to undesirable effects such as psychological stress, discomfort in daily activities, negative selfesteem, and impaired respiratory function , and their effectiveness remains controversial . Manipulative therapy aims to correct the alignment of spinal segments and optimize the mechanical interaction between the spine and torso to facilitate healing and restore spinal mobility. Therefore, manipulative therapy focusing on correcting the position of spinal segments and improving neuromuscular stabilization is needed to manage IS \[9\]. Such treatments include chiropractic therapy, Chuna manual therapy (CMT), and spinal realignment therapy (SRT).

The difference among these three treatment modalities is the patient's posture during treatment. During chiropractic treatment or CMT, the patient lies in the supine or prone position. During SRT, the patient lies in the prone position, and the lower extremities are placed under traction against gravity using SpineCare. SpineCare (Korea, Dr. Bom, Co., Ltd.) is a modernized traction device inspired by Panseo (攀索), which was introduced in the section on external therapy techniques (正骨心法要旨) in "Yizong Jinjian," a medical treatise compiled by Wu Jia (吳假) and others during the Qing Dynasty. This contraption received medical device certification from the Korean Ministry of Food and Drug Safety in 2020 (License No. 20-5054). The SpineCare device is used by having the patient lying prone with knees bent at 90º and both ankles secured on ankle braces to pull them up-wards against gravity. This posture helps create space between spinal segments, allowing deformed spinal and skeletal structures to return to their normal positions. With-out SpineCare, spinal imbalance may not be adequately addressed and corrected. Administering corrective treatment without spinal segment spacing may actually decrease spacing, increase pressure between the discs and vertebrae, and exacerbate disc abnormalities. Furthermore, it may affect the adjacent muscles and ligaments, thereby increasing pain and restricting movement and function, which, in turn, could cause discomfort and limitations in performing the activities of daily living. Thus, ensuring adequate space be-tween spinal segments using SpineCare is crucial for restoring the normal positions of the spine and skeletal structures.

However, research on the effectiveness of SRT using SpineCare is insufficient. There-fore, this study aimed to assess the effectiveness and safety of the application of SRT in conjunction with SpineCare in patients with IS. In this study, we will elaborate on the specific procedures involved in SRT with SpineCare for patients with IS and report the out-comes using NRS and Cobb's angle.
2. Materials and Methods 2.1. Study Design and Setting This investigator-initiated, randomized controlled, single-blind trial was approved by the Institutional Review Board (Date of approval: Rebom Clinic June 1, 2023). Written informed consent was obtained from all patients before trial commencement.

2.2. Participants Participants were enrolled from among the patients of Rebom Clinic from June 1 to November 30, 2023, by posting a recruitment announcement within the clinic. The inclusion criteria were age ranging from 19-70 years and spinal radiographs obtained in an upright position. Patients with a Cobb's angle of 15-39º on X-rays who consented to participate in the trial were included. The exclusion criteria were spine-related surgery in the past six months, diagnosis of osteoporosis, history of other non-surgical treatments, participation in another interventional clinical trial in the past month (including human studies), and plan to participate in another interventional study after starting this trial.

2.3. Randomization and Allocation Concealment The investigator responsible for data analysis prepared two envelopes marked with odd and even numbers. Participants chose an envelope in the order of arrival. To maintain a 1:1 ratio between the trial and control groups, participants were assigned to the remaining group once one group reached capacity. Participants who chose an odd number were assigned to the SpineCare based SRT group (trial group, TG), and those who chose an even number were assigned to the SRT group without SpineCare (control group, CG).

2.4. Outcomes 2.4.1. Primary Outcome Measure The primary outcome was the Numerical Rating Scale (NRS) score, which was used to quantify the subjective pain experienced by the patient over the past week . Patients selected a number that best reflected their pain intensity, where 0 indicates no pain and 10 represents extreme pain, with higher values indicating greater severity of pain. There is consensus that the NRS has greater validity and intensity compared to other instruments . The Pearson correlation coefficient (r = 0.93) indicating the correlation be-tween the NRS and Visual Analog Scale indicates robust validity and reliability.

2.4.2. Secondary Outcome Measures The secondary outcome measure was Cobb's angle, which is typically used to assess the severity of scoliosis. Cobb's angle is defined as the angle between a line parallel to the upper border of the upper vertebra and a line parallel to the lower border of the lowermost vertebra of the lateral curvature of the spine . The inter-rater and intrarater reliability coefficients for measuring Cobb's angle are 0.970 and 0.969, respectively.

2.4.3 Safety Adverse events were monitored through patient interviews before and after treatment. Participants were also instructed to notify the medical team by phone any time upon occurrence of an adverse event.

2.5. Interventions Korean medicine doctors performed the treatment regimens for both groups. The TG underwent SRT with SpineCare, while the CG underwent SRT without SpineCare. Treat-ment was administered for six consecutive weeks, with sessions held twice per week dur-ing the first four weeks and once per week during the final two weeks . No additional treatments (e.g., procedures or surgeries) were allowed during the six-week period. To analyze pain according to the number of treatment sessions, a counselor assessed patients using the NRS after each of the ten treatment sessions. To compare the differences in Cobb's angle between the groups, X-rays were performed after the first and tenth treatment sessions. Detailed records of adverse events were maintained before and after each treat-ment session.

2.5.1. Spinal Realignment Therapy SRT, an original spinal alignment technique developed by the Society of Spinal Conduction Exercise and Manipulation, functions as a diagnostic and manual therapeutic technique to promote balance and improve harmony in the human body. In this study, SRT was implemented in three steps.

Step 1 entailed the application of traction. With the patient lying on their side, the practitioner grasps the leg on top at the dorsum and heel and slowly pulls it. This motion slightly dislocates the femoral head from the hip joint, allowing it to realign to its normal position, thereby relieving deformities in the hip joint and tension in the surrounding muscles and soft tissues. Next, the patient lies prone with knees bent. The ankles are then secured with SpineCare's ankle braces, and the knees are lifted slightly against gravity. In this position, the practitioner uses their hands or feet to apply frictional force, pushing the sacrum towards the direction of the coccyx to correct the former's position.

Step 2 entails the application of pressure and thrust. This step treats pelvic imbalance while the patient is prone with the lower limbs lifted against gravity. The practitioner places their hands or feet on the patient's right and left iliac crests, sacroiliac joints, and sacrum, using their body weight to exert pressure. This process aims to correct any misa-lignment of the sacrum and sacroiliac joints as well as the imbalance of the left and right ilia.

Step 3 entails securing the intervertebral space. The practitioner addresses the im-balance in the thoracolumbar region, while the patient remains prone with the lower limbs lifted against gravity. The practitioner applies pressure sequentially to the patient's deformed sacral spinous processes, lumbar spinous processes, and thoracic spinous pro-cesses using their hands or feet. This technique aims to align the position of the sacrum, the space between L5-S1, and the space between the facet joints and spinous processes of the lumbar and thoracic segments to their normal positions.

2.5.2. SpineCare In the TG, patients lay prone on the SpineCare mattress. When patients bend their knees, the practitioner secures both ankles in SpineCare's ankle braces. Next, the legs are lifted against gravity to a height of 1-5 cm above the floor till a point that does not strain the patient's pelvis based on the physician's judgment. In this position, steps 1-3 of the SRT are performed . After treatment, the legs are lowered to the floor using SpineCare's ankle braces.

The CG underwent steps 1-3 while lying prone on a regular therapy mattress .

2.6. Statistical Analysis Statistical analyses were performed using SPSS 18.0 for Windows (SPSS Inc., Chicago, IL, USA). NRS scores after each treatment session were compared (sessions 1-10). Data between the TG and CG were compared using Wilcoxon's signed-rank test and the Mann-Whitney U test. The values of Cobb's angle at baseline (session 1) and after the tenth treatment session were compared. All data were presented as the mean ± standard devia-tion or number (%). p-values \<.05 were deemed statistically significant. Odds ratios were computed for comparison between the TG and CG, including the main analysis, and re-sults were deemed significant when the 95% confidence interval (CI) did not include 1. Adverse events were presented as frequencies and percentages, and the chi-squared test or Fisher's exact test (Fisher's exact test is used when more than 25% of the cells have an ex-pected frequency of less than 5) was used to compare the groups as needed.

Conditions

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Scoliosis Idiopathic

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Participants

Study Groups

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SRT with SpineCare

The Trial Group underwent Spinal realignment therapy with SpineCare

Group Type EXPERIMENTAL

SRT with SpineCare

Intervention Type DEVICE

Korean medicine doctors performed the treatment regimens.The TG underwent SRT with SpineCare. Treat-ment was administered for six consecutive weeks, with sessions held twice per week dur-ing the first four weeks and once per week during the final two weeks. No additional treatments (e.g., procedures or surgeries) were allowed during the six-week period. To an-alyze pain according to the number of treatment sessions, a counselor assessed patients using the NRS after each of the ten treatment sessions. To compare the differences in Cobb's angle between the groups, X-rays were performed after the first and tenth treatment sessions. Detailed records of adverse events were maintained before and after each treat-ment session.

SRT without SpineCare

The Control Group underwent Spinal realignment therapy without SpineCare

Group Type ACTIVE_COMPARATOR

SRT without SpineCare

Intervention Type DEVICE

Korean medicine doctors performed the treatment regimens. The CG underwent SRT without SpineCare. Treat-ment was administered for six consecutive weeks, with sessions held twice per week dur-ing the first four weeks and once per week during the final two weeks. No additional treatments (e.g., procedures or surgeries) were allowed during the six-week period. To an-alyze pain according to the number of treatment sessions, a counselor assessed patients using the NRS after each of the ten treatment sessions. To compare the differences in Cobb's angle between the groups, X-rays were performed after the first and tenth treatment sessions. Detailed records of adverse events were maintained before and after each treat-ment session.

Interventions

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SRT with SpineCare

Korean medicine doctors performed the treatment regimens.The TG underwent SRT with SpineCare. Treat-ment was administered for six consecutive weeks, with sessions held twice per week dur-ing the first four weeks and once per week during the final two weeks. No additional treatments (e.g., procedures or surgeries) were allowed during the six-week period. To an-alyze pain according to the number of treatment sessions, a counselor assessed patients using the NRS after each of the ten treatment sessions. To compare the differences in Cobb's angle between the groups, X-rays were performed after the first and tenth treatment sessions. Detailed records of adverse events were maintained before and after each treat-ment session.

Intervention Type DEVICE

SRT without SpineCare

Korean medicine doctors performed the treatment regimens. The CG underwent SRT without SpineCare. Treat-ment was administered for six consecutive weeks, with sessions held twice per week dur-ing the first four weeks and once per week during the final two weeks. No additional treatments (e.g., procedures or surgeries) were allowed during the six-week period. To an-alyze pain according to the number of treatment sessions, a counselor assessed patients using the NRS after each of the ten treatment sessions. To compare the differences in Cobb's angle between the groups, X-rays were performed after the first and tenth treatment sessions. Detailed records of adverse events were maintained before and after each treat-ment session.

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* 19-70 years
* Patients with a Cobb's angle of 15-39º on X-rays who consented to par-ticipate in the trial were included.

Exclusion Criteria

* spine-related surgery in the past six months,
* diagnosis of osteoporosis,
* history of other non-surgical treatments,
* participation in another interventional clinical trial in the past month
Minimum Eligible Age

19 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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REBOM CLINIC

OTHER

Sponsor Role lead

Responsible Party

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Sohyun Kim

Dr. SH Kim

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Rebom Clinic

Seoul, Gangnam, South Korea

Site Status

Countries

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South Korea

References

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Other Identifiers

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RBIRB

Identifier Type: -

Identifier Source: org_study_id

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