tDCS in People With Subthreshold Depression

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

204 participants

Study Classification

INTERVENTIONAL

Study Start Date

2026-01-16

Study Completion Date

2027-01-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

This study evaluates the effects of multi-session transcranial direct current stimulation on loneliness, mood and depressiveness in people with subthreshold depression.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Transcranial Direct Current Stimulation (tDCS) in Young Individuals with Major Depressive Disorder: a Literature Review and Feasibility Study

NCT06518642

Major Depressive Disorder

COMPLETED NA

Treating Loneliness In The Older Adult With Depression With tDCS

NCT06658795

Major Depressive Disorder Loneliness

RECRUITING NA

The Effects of Transcranial Direct Current Stimulation (tDCS) in Older Lonely Individuals

NCT05937022

Loneliness

RECRUITING NA

The Effect of Transcranial Direct Current Stimulation (tDCS) in Improving Emotion Health

NCT07319143

Subthreshold Depression Positive Emotions Negative Emotions +1 more

RECRUITING NA

TDCS Interventions for Subthreshold Depressive Symptoms in Young Individuals.

NCT06294184

Subthreshold Depression Young People Transcranial Direct Current Stimulation

RECRUITING NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Depression-prone individuals will be invited and allocated to three groups, either the personalised transcranial direct current stimulation (tDCS) group, the conventional tDCS group, or the sham control group. After screening and at baseline prior to the tDCS sessions, participants will complete tests and questionnaires on depression symptoms, loneliness and mood. Eligible participants will also be invited to receive functional magnetic resonance imaging (MRI) in a 3-Tesla MRI scanner. There will be a maximum of 10 sessions to be completed after the screening and baseline measures. For both personalised tDCS group and the conventional tDCS group, tDCS with 2 milliampere (mA) intensity will be delivered for 20 minutes in each session. For sham control group, the protocol will be similar, except that the stimulation only happens in the first 30 seconds in each session. Especially for participants allocated to the personalised tDCS group, the stimulation site for each individual in this group may vary, depending on their brain activations and connectivity. The anodal stimulation sites for participants allocated to the conventional tDCS group and the sham control group will be F3 within the left DLPFC. Immediately after and also 3-months after completing all the tDCS sessions, participants will be invited to complete again tests and questionnaires on depressive symptoms in addition to loneliness and mood. Eligible participants will also be invited to receive functional MRI scanning in the 3T MRI scanner again. Participants will also be prompted to self-report daily their loneliness and mood levels throughout the study.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Subthreshold Depression

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Outcome Assessors

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Personalised tDCS group

Participants who are assigned to the personalised group will receive anodal tDCS over a individualized stimulation site.

Group Type EXPERIMENTAL

Personalized Experimental Transcranial Direct Current Stimulation (tDCS)

Intervention Type DEVICE

This study will deliver tDCS sessions for a maximum of ten sessions in two weeks' time. Participants will receive 20 minutes of active stimulation with a 2mA intensity over personalized brain regions based on the particular neural correlates of socio-affective processing.

Conventional tDCS group

Participants who are assigned to the Conventional group will receive anodal tDCS over F3.

Group Type EXPERIMENTAL

Conventional Experimental Transcranial Direct Current Stimulation (tDCS)

Intervention Type DEVICE

This study will deliver tDCS sessions for a maximum of ten sessions in two weeks' time. Participants will receive 20 minutes of active stimulation with a 2mA intensity with anode placed over F3.

Sham control group

Participants who are assigned to the Conventional group will receive sham tDCS. The active stimulation will be delivered for the first 30 seconds only.

Group Type SHAM_COMPARATOR

Sham Transcranial Direct Current Stimulation (tDCS)

Intervention Type DEVICE

This study will deliver tDCS sessions for a maximum of ten sessions in two weeks' time. Participants assigned to the sham control group will only receive 30 seconds of active stimulation.

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Personalized Experimental Transcranial Direct Current Stimulation (tDCS)

This study will deliver tDCS sessions for a maximum of ten sessions in two weeks' time. Participants will receive 20 minutes of active stimulation with a 2mA intensity over personalized brain regions based on the particular neural correlates of socio-affective processing.

Intervention Type DEVICE

Sham Transcranial Direct Current Stimulation (tDCS)

This study will deliver tDCS sessions for a maximum of ten sessions in two weeks' time. Participants assigned to the sham control group will only receive 30 seconds of active stimulation.

Intervention Type DEVICE

Conventional Experimental Transcranial Direct Current Stimulation (tDCS)

This study will deliver tDCS sessions for a maximum of ten sessions in two weeks' time. Participants will receive 20 minutes of active stimulation with a 2mA intensity with anode placed over F3.

Intervention Type DEVICE

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* No histories of learning impairment, major psychiatric disorders including Major Depressive Disorder or neurological disorders
* At least primary school education
* Subthreshold depression

Exclusion Criteria

* On medication or treatments within 2 weeks prior to the beginning of the study that would affect the individual's brain, cognitive and affective functions

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes