A Study to Evaluate Solriktug in Adult Participants With Asthma

NCT ID: NCT06496607

Last Updated: 2025-11-24

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

PHASE2

Total Enrollment

124 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-07-26

Study Completion Date

2026-04-30

Brief Summary

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Phase 2 study to evaluate the safety, tolerability, PK, immunogenicity, and pharmacodynamics of solriktug with adult participants with asthma.

Detailed Description

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This is a 12-week randomized, double-blind, placebo-controlled Phase 2 clinical study to evaluate the safety, tolerability, PK, immunogenicity, and pharmacodynamics of 3 dose levels of solrikitug versus placebo on top of standard of care in adult participants with asthma.

Approximately 124 adult participants with asthma will be randomized. Participants will receive solrikitug, or placebo, administered via subcutaneous injection at the study site, over a 12-week treatment period. The study also includes a post-treatment follow-up period of 16 weeks.

Conditions

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Asthma

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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Solrikitug low dose subcutaneous injection

Solrikitug

Group Type EXPERIMENTAL

NSI-8226

Intervention Type BIOLOGICAL

Solrikitug

Solrikitug mid dose subcutaneous injection

Solrikitug

Group Type EXPERIMENTAL

NSI-8226

Intervention Type BIOLOGICAL

Solrikitug

Solrikitug high dose subcutaneous injection

Solrikitug

Group Type EXPERIMENTAL

NSI-8226

Intervention Type BIOLOGICAL

Solrikitug

Placebo subcutaneous injection

Placebo

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type BIOLOGICAL

Placebo

Interventions

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NSI-8226

Solrikitug

Intervention Type BIOLOGICAL

NSI-8226

Solrikitug

Intervention Type BIOLOGICAL

NSI-8226

Solrikitug

Intervention Type BIOLOGICAL

Placebo

Placebo

Intervention Type BIOLOGICAL

Eligibility Criteria

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Inclusion Criteria

* Participant must be aged 18 to 75 years of age.
* Documented diagnosis of asthma at least 12 months prior to Screening.
* Participants must be on maintenance asthma medications, for at least 3 months prior to screening: inhaled corticosteroid (ICS) in combination with long-acting beta agonist (LABA), or as part of an approved triple therapy for asthma (ICS/LABA/long-acting muscarinic antagonist \[LAMA\]).
* Participant has an ACQ-6 score ≥1.5 at Screening Visit.
* Participant has FEV1 of ≥50% to 90%, inclusive, of predicted normal value at Screening Visit 1.
* Evidence of asthma as documented by reversibility in FEV1 of ≥12% and ≥200 mL over the pre-salbutamol FEV1 at Screening Visit.

Exclusion Criteria

* Female participant who is pregnant or breastfeeding.
* Participant is a current smoker, or former smoker with a smoking history of ≥10 pack-years.
* Participant has a known hypersensitivity to any component of the formulation of solrikitug, including any of the excipients, or a history of anaphylactic reaction to any therapeutic monoclonal antibody.
* Participant has history or evidence of any clinically significant cardiovascular, hematologic, hepatic, immunologic, metabolic, urologic, neurologic, dermatologic, psychiatric, renal and/or other major disease or malignancy, or any other condition (risks factors of pneumonia) that in the opinion of the Investigator might obfuscate the study data.
* Participant has an exacerbation of asthma requiring use of OCS or hospitalization in the 6 weeks prior to Screening or during the Screening Period.
* Participant has history or evidence of any clinically significant pulmonary condition, other than asthma.
* Lower respiratory tract infection within the 6 weeks prior to Screening.
Minimum Eligible Age

18 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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DevPro Biopharma

INDUSTRY

Sponsor Role collaborator

Uniquity One (UNI)

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Andrew W Lee, MD

Role: STUDY_DIRECTOR

Vice President, Clinical Research

Locations

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Research Site 006

Mobile, Alabama, United States

Site Status RECRUITING

Research Site 076

Peoria, Arizona, United States

Site Status RECRUITING

Research Site 021

Huntington Beach, California, United States

Site Status RECRUITING

Research Site 082

La Mesa, California, United States

Site Status RECRUITING

Research Site 031

Los Angeles, California, United States

Site Status RECRUITING

Research Site 020

Newport Beach, California, United States

Site Status RECRUITING

Research Site 037

Rancho Cucamonga, California, United States

Site Status RECRUITING

Research Site 036

San Jose, California, United States

Site Status RECRUITING

Research Site 062

San Jose, California, United States

Site Status RECRUITING

Research Site 071

West Covina, California, United States

Site Status RECRUITING

Research Site 024

Englewood, Colorado, United States

Site Status RECRUITING

Research Site 001

Clearwater, Florida, United States

Site Status RECRUITING

Research Site 026

Cutler Bay, Florida, United States

Site Status RECRUITING

Research Site 069

DeLand, Florida, United States

Site Status RECRUITING

Research Site 025

Leesburg, Florida, United States

Site Status RECRUITING

Research Site 003

Miami, Florida, United States

Site Status RECRUITING

Research Site 030

Miami Gardens, Florida, United States

Site Status RECRUITING

Research Site 041

Tallahassee, Florida, United States

Site Status RECRUITING

Research Site 081

Tamarac, Florida, United States

Site Status RECRUITING

Research Site 080

Cordele, Georgia, United States

Site Status RECRUITING

Research Site 084

East Point, Georgia, United States

Site Status RECRUITING

Research Site 052

Savannah, Georgia, United States

Site Status RECRUITING

Research Site 065

Boise, Idaho, United States

Site Status RECRUITING

Research Site 022

Meridian, Idaho, United States

Site Status RECRUITING

Research Site 018

Winfield, Illinois, United States

Site Status RECRUITING

Research Site 019

Merrillville, Indiana, United States

Site Status RECRUITING

Research Site 011

Sioux City, Iowa, United States

Site Status RECRUITING

Research Site 005

Lafayette, Louisiana, United States

Site Status RECRUITING

Research Site 027

White Marsh, Maryland, United States

Site Status RECRUITING

Research Site 016

Russells Mills, Massachusetts, United States

Site Status RECRUITING

Research Site 087

Dearborn, Michigan, United States

Site Status RECRUITING

Research Site 033

Farmington Hills, Michigan, United States

Site Status RECRUITING

Research Site 086

Southfield, Michigan, United States

Site Status RECRUITING

Research Site 032

Missoula, Montana, United States

Site Status RECRUITING

Research Site 014

Henderson, Nevada, United States

Site Status RECRUITING

Research Site 073

Queens Village, New York, United States

Site Status RECRUITING

Research Site 004

Gastonia, North Carolina, United States

Site Status RECRUITING

Research 013

Winston-Salem, North Carolina, United States

Site Status RECRUITING

Research Site 075

Lima, Ohio, United States

Site Status RECRUITING

Research Site 061

Toledo, Ohio, United States

Site Status RECRUITING

Research Site 007

Edmond, Oklahoma, United States

Site Status RECRUITING

Research Site 009

Medford, Oregon, United States

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Research Site 045

Portland, Oregon, United States

Site Status RECRUITING

Research Site 083

DuBois, Pennsylvania, United States

Site Status RECRUITING

Research Site 063

Philadelphia, Pennsylvania, United States

Site Status RECRUITING

Research Site 046

Mauldin, South Carolina, United States

Site Status RECRUITING

Research Site 066

North Charleston, South Carolina, United States

Site Status RECRUITING

Research Site 038

Hendersonville, Tennessee, United States

Site Status RECRUITING

Research Site 028

Knoxville, Tennessee, United States

Site Status RECRUITING

Research Site 017

Boerne, Texas, United States

Site Status RECRUITING

Research Site 072

Brownsville, Texas, United States

Site Status RECRUITING

Research Site 085

Carrollton, Texas, United States

Site Status RECRUITING

Research Site 078

Conroe, Texas, United States

Site Status RECRUITING

Research Site 042

Dallas, Texas, United States

Site Status RECRUITING

Research Site 010

Dallas, Texas, United States

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Research Site 064

Frisco, Texas, United States

Site Status RECRUITING

Research Site 074

Greenville, Texas, United States

Site Status RECRUITING

Research Site 015

Houston, Texas, United States

Site Status RECRUITING

Research Site 010

McKinney, Texas, United States

Site Status RECRUITING

Research Site 023

Hampton, Virginia, United States

Site Status RECRUITING

Countries

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United States

Central Contacts

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Uniquity One Clinical Trials

Role: CONTACT

484-267-2500

Anushri Walsh

Role: CONTACT

973-983-3700

Facility Contacts

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Research Site

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Other Identifiers

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NSI-8226-204

Identifier Type: -

Identifier Source: org_study_id

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