Evaluation of Axillary Lymph Node Metastasis Status of Breast Cancer Based on Pathological Images and Virtual Staining
NCT ID: NCT06486155
Last Updated: 2024-08-13
Study Results
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Basic Information
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NOT_YET_RECRUITING
2200 participants
OBSERVATIONAL
2024-08-31
2025-12-31
Brief Summary
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Can the virtual staining model generate hematoxylin and eosin (H\&E) and immunohistochemistry (IHC) images suitable for clinical diagnosis from unstained paraffin-embedded lymph node slice images, including those from breast axillary lymph nodes and other tumor lymph nodes?
Can the virtual staining model generate H\&E and IHC images suitable for clinical diagnosis from unstained frozen sentinel lymph node slice images from breast cancer patients?
Researchers will retrospectively collect paraffin-embedded lymph node slices from tumor patients and prospectively collect frozen sentinel lymph node slices from breast cancer patients.
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Detailed Description
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Conditions
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Study Design
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OTHER
PROSPECTIVE
Eligibility Criteria
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Inclusion Criteria
Female patients aged 18-75 with breast cancer; Undergoing surgical excision of breast cancer and sentinel lymph node biopsy/axillary lymph node dissection; Lymph nodes with clear postoperative paraffin pathological results.
Part 2:
Patients aged 18-75 with one of the following cancers: thyroid, lung, esophagus, stomach, colorectal, prostate, bladder, or cervix; Undergoing surgical resection of lymph nodes; Lymph nodes with clear postoperative paraffin pathological results.
Part 3:
Female patients aged 18-75 with breast cancer; Undergoing surgical excision of breast cancer and sentinel lymph node biopsy; Sentinel lymph nodes with clear postoperative paraffin pathological results.
Exclusion Criteria
Lymph node diagnosis is missing; Absence of lymph node component in the slice.
Part 3:
Sentinel lymph node diagnosis is missing; Absence of lymph node component in the frozen slice.
18 Years
75 Years
ALL
No
Sponsors
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Affiliated Cancer Hospital of Shantou University Medical College
OTHER
Yunnan Cancer Hospital
OTHER
Responsible Party
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Other Identifiers
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KYLX2024-129
Identifier Type: -
Identifier Source: org_study_id
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