Role of Low-Molecular-Weight Heparin in Unexplained Recurrent Pregnancy Loss

NCT ID: NCT06484634

Last Updated: 2024-07-03

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

175 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-12-01

Study Completion Date

2024-05-31

Brief Summary

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Using low-molecular-weight heparin (LMWH), outcomes such as live birth rate and the occurrence of pregnancy complications are some of the variables reported in some studies, with varying degrees of success. The present study aimed to compare the role of LMWH in unexplained recurrent pregnancy loss.

Detailed Description

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Conditions

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Pregnancy Loss

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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LMWH Group

Women received a daily dose of 40 mg of Low Molecular Weight Heparin subcutaneously.

Group Type EXPERIMENTAL

Low molecular weight heparin

Intervention Type DRUG

A daily dose of 40 mg of low-molecular-weight heparin (LMWH) subcutaneously was given to the patients.

Control

Women received the placebo in the form of a multivitamin tablet.

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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Low molecular weight heparin

A daily dose of 40 mg of low-molecular-weight heparin (LMWH) subcutaneously was given to the patients.

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Pregnant females between 18 and 44 years of age
* Gestational age above 8 weeks
* A history of ≥3 consecutive first trimester pregnancy losses

Exclusion Criteria

* Patients with systemic lupus erythematosus
* Positive IgG and IgM anticardiolipin antibodies
* Positive for thrombophilia screening
* Any platelet function abnormality or a previous thromboembolic event requiring anticoagulant therapy (including heparin, aspirin or warfarin)
* Sensitive to acetylsalicylic acid, heparin, or warfarin
* Patients with any genetic, anatomical, or hormonal cause of recurrent pregnancy loss
Minimum Eligible Age

18 Years

Maximum Eligible Age

44 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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RESnTEC, Institute of Research

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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DG Khan Hospital

Dera Ghazi Khan, Punjab Province, Pakistan

Site Status

Countries

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Pakistan

Other Identifiers

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LMWHDGKHAN

Identifier Type: -

Identifier Source: org_study_id

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