Mobility Assessment in Multi-morbidity

NCT ID: NCT06473168

Last Updated: 2024-06-25

Basic Information

• Recruitment Status: NOT_YET_RECRUITING
• Total Enrollment: 55 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2024-12-01
• Study Completion Date: 2025-12-31

Brief Summary

Multimorbidity (the presence of two or more coexisting long-term conditions) is a significant challenge facing the NHS, especially given UK's ageing population and the association with high levels of illness burden and healthcare costs. Over 50% of adults >65 years have multiple long-term conditions (MLTCs).

Our group has validated a broad range of algorithms applied to single wearable sensors that have the potential to capture walking-related mobility outcomes (such as walking cadence and walking speed) accurately and reliably during activities of daily living across five single long-term conditions. These algorithms, however, cannot be readily applied to people with MLTCs because the effect of multimorbidity on mobility is amplified compared to single long-term conditions secondary to a greater number of complications and sequelae. Accordingly, the aim of this study is to validate algorithms that would allow robust estimation of walking-related mobility outcomes during daily life activities in MLTCs.

To meet our objectives, the investigators will perform: i) laboratory-based technical validation of existing and newly developed algorithms for walking-related mobility outcome detection; ii) unsupervised real-life validation of selected algorithms; and iii) examination of how well the validated walking-related mobility outcomes reflect global and disease specific characteristics in older adults with multimorbidity. The investigators will adopt an integrated patient-centric approach where patients with MLTCs will be engaged early in the project to provide input of their perception and concerns regarding mobility limitation in daily life activities.

The investigators aim to recruit 55 older adults (>65 years), men and women, with multiple long-term conditions with the following inclusion criteria: having two or more of the following conditions including osteoarthritis, rheumatoid arthritis, osteoporosis, type 2 diabetes, depression and/or anxiety, hypertension, coronary heart disease, heart failure, atrial fibrillation, chronic obstructive pulmonary disease, asthma, bronchiectasis, chronic kidney disease, cancer, or stroke within the last 5 years.

Conditions

Arthritis; Asthma; Atrial Fibrillation; Bronchiectasis; Cancer; Chronic Kidney Diseases; Chronic Obstructive Pulmonary Disease; Coronary Heart Disease; Anxiety; Depression; Diabetes Mellitus; Heart Failure; Hypertension; Osteoporosis; Parkinson Disease; Peripheral Vascular Disease; Stroke; Transient Ischemic Attack

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Eligibility Criteria

Inclusion Criteria

• Adults ≥65 years old
• Able and willing to provide informed consent
• Able to read and write in English
• To be mobile (including the use of walking aids)
• Two or more of the following long terms conditions: Arthritis, Asthma, Atrial fibrillation, Bronchiectasis, Cancer, Chronic kidney disease, Chronic obstructive pulmonary disease, Coronary heart disease, Anxiety, Depression, Diabetes mellitus, Heart failure, Hypertension, Osteoporosis, Parkinson's disease, Peripheral vascular disease, Stroke or transient ischaemic attack

Exclusion Criteria

• Unable to give consent for the study
• Severe mental health problems
• Active malignancy (on chemotherapy/radiotherapy/planned urgent surgery)

• Minimum Eligible Age: 65 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Newcastle University

OTHER

Sponsor Role: collaborator

Northumbria University

OTHER

Sponsor Role: lead

Responsible Party

Ioannis Vogiatzis

Professor of Rehabilitation Sciences

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Laura Hutchinson, BSc

Role: STUDY_CHAIR

Northumbria University Newcastle

Central Contacts

Ioannis Vogiatzis, PhD

Role: CONTACT

ioannis.vogiatzis@northumbria.ac.uk

+44 (0)191 349 5446

Other Identifiers

700448

Identifier Type: -

Identifier Source: org_study_id