Shock Wave Therapy for Lower Limb Lymphedema

NCT ID: NCT06454734

Last Updated: 2025-07-31

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

30 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-05-28

Study Completion Date

2026-12-31

Brief Summary

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This is a double-blind randomized clinical trial to compare the effect of shock wave therapy on lower limb lymphedema. There are two arms: A) complex decongestive therapy + extracorporeal shock waves therapy; B) complex decongestive therapy plus placebo extracorporeal shock waves.

Detailed Description

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This is a double blind, randomized, clinical trial. 30 patients with lower limb lymphedema will be randomized in 2 groups. One group will receive the habitual complex decongestive therapy (lymphatic manual drainage and compression) plus extracorporeal shock waves therapy. The other group will receive complex decongestive therapy (lymphatic manual drainage and compression) plus placebo extracorporeal shock waves.

Patients in the 2 groups will be instructed on skin care measures and kinesitherapy. The usual manual lymphatic drainage and compression will be applied to the 2 groups. The 2 groups will receive 10 treatment sessions, 2 weekly for 5 weeks.

Group complex decongestive therapy + shock waves. Patients will receive treatment with manual lymphatic drainage, compression, and shock waves.

Group complex decongestant therapy + placebo. Patients will receive treatment with manual lymphatic drainage, compression, and placebo shock waves.

Tolerance and possible adverse effects will be recorded by physiotherapist. Any adverse effect detected will be evaluated by the rehabilitation medical doctor.

Conditions

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Lymphedema, Lower Limb

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Double blind randomized clinical trial
Primary Study Purpose

TREATMENT

Blinding Strategy

TRIPLE

Participants Investigators Outcome Assessors
Patients, outcome assessors and investigators will not know if received treatment was placebo or therapeutic. The physiotherapist will apply the treatment according to a list of random numbers generated to make 2 treatment groups

Study Groups

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DLT + ESWT

To DLT + ESWT group, decongestive lymphatic therapy (DLT) plus radial extracorporeal wave treatment (ESWT) will be applied, at a dose and intensity probed to be useful to diminish volume in upper limb lymphedema.

Group Type EXPERIMENTAL

Extracorporeal shock wave therapy by radial device

Intervention Type DEVICE

Patients will receive treatment by extracorporeal shock waves therapy (ESWT).

DLT

Intervention Type OTHER

Patients will receive treatment with decongestive lymphatic therapy (DLT: manual lymphatic drainage, compression)

DLT + Sham ESWT

To DLT + Sham ESWT group, decongestive lymphatic therapy plus sham radial extracorporeal wave treatment will be applied, at a placebo dose and intensity.

Group Type SHAM_COMPARATOR

Placebo extracorporeal shock wave therapy by radial device

Intervention Type DEVICE

Patients will receive treatment sham extracorporeal shock waves.

DLT

Intervention Type OTHER

Patients will receive treatment with decongestive lymphatic therapy (DLT: manual lymphatic drainage, compression)

Interventions

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Extracorporeal shock wave therapy by radial device

Patients will receive treatment by extracorporeal shock waves therapy (ESWT).

Intervention Type DEVICE

Placebo extracorporeal shock wave therapy by radial device

Patients will receive treatment sham extracorporeal shock waves.

Intervention Type DEVICE

DLT

Patients will receive treatment with decongestive lymphatic therapy (DLT: manual lymphatic drainage, compression)

Intervention Type OTHER

Other Intervention Names

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Radial ESWT rESWT Radial ESWT rESWT Decongestive Lymphatic Therapy

Eligibility Criteria

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Inclusion Criteria

* Patients with lower limb lymphedema
* Lymphedema of at least 6 months of evolution
* The lymphedema must affect at least the knee to the foot
* Moderate or severe lymphedema (grades 2 or 3)
* Sign the informed consent

Exclusion Criteria

* Under 18 years of age
* Coagulation disorders (hemophilia, treatment with acenocoumarol, etc.)
* Current or previous deep vein thrombosis of the lower extremity
* Pregnancy
* Electronic implantable medical devices as pacemaker implants, medication pumps, etc
* Having received treatment with complex decongestive therapy or shock waves during the last 6 months
* Treatment with corticosteroids or radiotherapy in the area to be treated in the last 6 weeks
* Active oncological disease in the area to be treated
* Active infectious-inflammatory process in the area to be treated
* Cognitive or sensory deficits that prevent collaboration
* Inability to walk independently or inability to attend therapy
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Parc de Salut Mar

OTHER

Sponsor Role lead

Responsible Party

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Roser Belmonte

Rehabilitation specialist, MD, PhD

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Roser Belmonte, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Hospital del Mar

Locations

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Hospital del Mar

Barcelona, , Spain

Site Status RECRUITING

Countries

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Spain

Central Contacts

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Roser Belmonte, MD, PhD

Role: CONTACT

+34 933674214

Esther Duarte, MD, PhD

Role: CONTACT

+34 933674214

Facility Contacts

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Esther Duarte, PhD

Role: primary

933674214

Roser Belmonte, PhD

Role: backup

933674214

References

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Rankin J, Morris K, Reilly A. The All-Ireland Guidelines for the diagnosis, assessment and management of lymphoedema. Br J Community Nurs. 2022 Oct 1;27(Sup10):S22-S26. doi: 10.12968/bjcn.2022.27.Sup10.S22.

Reference Type BACKGROUND
PMID: 36205409 (View on PubMed)

Bae H, Kim HJ. Clinical outcomes of extracorporeal shock wave therapy in patients with secondary lymphedema: a pilot study. Ann Rehabil Med. 2013 Apr;37(2):229-34. doi: 10.5535/arm.2013.37.2.229. Epub 2013 Apr 30.

Reference Type BACKGROUND
PMID: 23705118 (View on PubMed)

Tsai YL, I TJ, Chuang YC, Cheng YY, Lee YC. Extracorporeal Shock Wave Therapy Combined with Complex Decongestive Therapy in Patients with Breast Cancer-Related Lymphedema: A Systemic Review and Meta-Analysis. J Clin Med. 2021 Dec 19;10(24):5970. doi: 10.3390/jcm10245970.

Reference Type BACKGROUND
PMID: 34945266 (View on PubMed)

Lee KW, Kim SB, Lee JH, Kim YS. Effects of Extracorporeal Shockwave Therapy on Improvements in Lymphedema, Quality of Life, and Fibrous Tissue in Breast Cancer-Related Lymphedema. Ann Rehabil Med. 2020 Oct;44(5):386-392. doi: 10.5535/arm.19213. Epub 2020 Sep 28.

Reference Type BACKGROUND
PMID: 32986941 (View on PubMed)

Other Identifiers

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2023/11201/I

Identifier Type: -

Identifier Source: org_study_id

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