Letrozole and Misoprostol for Early Pregnancy Loss Management
NCT ID: NCT06452719
Last Updated: 2025-08-05
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
PHASE2
30 participants
INTERVENTIONAL
2024-08-22
2026-07-15
Brief Summary
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Detailed Description
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Conditions
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Study Design
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NA
SINGLE_GROUP
TREATMENT
NONE
Study Groups
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Letrozole & Misprostol
Letrozole 10 mg orally daily for three consecutive days followed by misoprostol 800 mcg vaginally within 24 hours of final letrozole dose
Letrozole
Letrozole 10 mg orally daily for three consecutive days
Misoprostol
Misoprostol 800 mcg vaginally within 24 hours of final letrozole dose
Interventions
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Letrozole
Letrozole 10 mg orally daily for three consecutive days
Misoprostol
Misoprostol 800 mcg vaginally within 24 hours of final letrozole dose
Eligibility Criteria
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Inclusion Criteria
* Stated willingness to comply with all study procedures and availability for the duration of the study
* Access to working mobile phone
* English-speaking
* Age 18 years or older
* Confirmed diagnosis of intrauterine embryonic/fetal demise or anembryonic gestation (ultrasound examination demonstrates a fetal pole without cardiac activity measuring between 5.3 and 40 mm or an abnormal growth pattern diagnostic of early pregnancy failure)
Exclusion Criteria
* Contraindication of allergy to letrozole or misoprostol
* Unable to return for clinic-based follow-up
* Twin or multiple pregnancy
18 Years
FEMALE
No
Sponsors
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University of Pennsylvania
OTHER
Responsible Party
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Locations
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PEACE / Penn Medicine
Philadelphia, Pennsylvania, United States
Countries
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Central Contacts
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Facility Contacts
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Arden McAllister, MPH
Role: primary
Other Identifiers
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855835
Identifier Type: -
Identifier Source: org_study_id
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