Estradiol Pretreatment With Misoprostol in Second Trimester Miscarriage
NCT ID: NCT03479879
Last Updated: 2019-01-29
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
PHASE2/PHASE3
200 participants
INTERVENTIONAL
2018-03-21
2018-12-20
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
QUADRUPLE
Study Groups
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Estradiol + Misoprostol
Estradiol
Estradiol
Misoprostol
Misoprostol
Placebo + Misoprostol
Placebo Oral Tablet
Placebo
Misoprostol
Misoprostol
Interventions
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Estradiol
Estradiol
Placebo Oral Tablet
Placebo
Misoprostol
Misoprostol
Eligibility Criteria
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Inclusion Criteria
* Gestational age between 12-26 weeks.
* Hb level \> 10 g/dL.
* BMI between 25 kg/m2 and 35 kg/m2.
* Missed abortion.
* Living fetus with multiple congenital malformations incompatible with life.
* PPROMS with drained liquor and parents are consenting for termination of pregnancy.
Exclusion Criteria
* Gestational age less than 12 weeks or more than 26 weeks.
* Hb level \< 10 g/dL.
* Scared uterus (previous myomectomy - cesarean section - hysterectomy and ruptured uterus).
* Polyhydramnios.
* Anencephaly.
* Fibroid uterus.
* BMI less than 25 kg/m2 and more than 35 kg/m2.
* Coagulopathy.
* Previous attempts for induction of abortion in the current pregnancy.
* Allergy to misoprostol or estradiol.
* Placenta previa.
* Medical disorder that contraindicate induction of abortion (e.g. heart failure).
18 Years
40 Years
FEMALE
No
Sponsors
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Ain Shams University
OTHER
Responsible Party
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Mohamed S Sweed, MD
Principal Investigator
Locations
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Ain Shams University Maternity Hospital
Cairo, , Egypt
Countries
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Other Identifiers
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AS1731
Identifier Type: -
Identifier Source: org_study_id
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