Durvalumab + Intraductal Radiofrequency Ablation (ID-RFA) in Extrahepatic Cholangiocarcinoma

NCT ID: NCT06440993

Last Updated: 2025-12-01

Basic Information

• Recruitment Status: RECRUITING
• Clinical Phase: PHASE2
• Total Enrollment: 42 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2024-08-23
• Study Completion Date: 2028-04-30

Brief Summary

The present clinical trial is a prospective, investigator-initiated, single-arm, open-label, multicenter phase II trial. Patients with unresectable perihilar and/or ductal CCA with indication for bile duct stenting and palliative systemic therapy as determined by the local multidisciplinary team (MDT), who already resolved cholestasis due to RFA + Stent will be enrolled.

We hypothesize that in patients with extrahepatic cholangiocarcinoma, the use of a combination radiofrequency ablation followed by systemic treatment with chemotherapy plus durvalumab might further increase the anti-tumor activity.

Conditions

Extrahepatic Cholangiocarcinoma; Unresectable Perihilar or Ductal CCA

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

systemic plus ID-RFA

systemic treatment: - combination treatment for 8 cycles (Q3W):

• Gemcitabine, 1,000 mg/m2 IV, on day 1 and 8,
• Cisplatin, 25 mg/m2 IV, on day 1 and 8
• Durvalumab, 1,500 mg IV, on day 1 followed by
• Durvalumab maintenance, 1,500 mg IV, PLUS • 2 endoscopic intraductal RFA

Group Type: EXPERIMENTAL

Gemcitabine

Intervention Type: DRUG

Gemcitabine, 1,000 mg/m2 IV

Cisplatin

Intervention Type: DRUG

Cisplatin, 25 mg/m2 IV

Durvalumab

Intervention Type: DRUG

Durvalumab, 1,500 mg IV

ID-RFA

Intervention Type: PROCEDURE

endoscopic intraductal RFA

Interventions

Gemcitabine

Gemcitabine, 1,000 mg/m2 IV

Intervention Type: DRUG

Cisplatin

Cisplatin, 25 mg/m2 IV

Intervention Type: DRUG

Durvalumab

Durvalumab, 1,500 mg IV

Intervention Type: DRUG

ID-RFA

endoscopic intraductal RFA

Intervention Type: PROCEDURE

Eligibility Criteria

Inclusion Criteria

1. Patient* has given written informed consent.

2. Patient is ≥ 18 years of age at time of signing the written informed consent.

3. Patient is willing and able to comply with the protocol for the duration of the study including undergoing treatment and scheduled visits and examinations including follow up.

4. Patient has been diagnosed with histologically or cytologically confirmed

1. histologically or cytologically confirmed cholangiocarcinoma as adenocarcinoma of pancreatobiliary type

2. unresectable perihilar and/or ductal cholangiocarcinoma with indication for bile duct stenting and palliative systemic therapy as determined by the local multidisciplinary team (MDT) and already resolved cholestasis due to RFA + stent

5. Patient tolerated RFA prior to inclusion and is eligible for repeat RFA during the study (does not have any contraindications) as determined by investigator.

6. Patient is eligible for palliative systemic therapy based on clinical and laboratory parameters (except hyperbilirubinemia) as determined by the local MDT

7. Patient has a ECOG ≤ 1.

8. Patient has life expectancy of ≥ 12 weeks

9. Patient has body weight > 30 kg

10. Adequate blood count, liver-enzymes, and renal function:

1. ANC > 1,500 cells/μL without the use of hematopoietic growth factors

2. Platelet count ≥ 100 x 109/L (>100,000 per mm3)

3. Hemoglobin ≥ 9 g/dL

4. Serum total bilirubin ≤ 3x upper normal limit (ULN) (biliary drainage is allowed for biliary obstruction; elevated bilirubin should be caused by obstruction not impaired liver function as assessed by albumin and INR values)

5. Albumin levels ≥ 2.8 g/dL

6. Patients not receiving therapeutic anticoagulation must have an INR< 2.0 ULN and PTT < 1.5 ULN within 7 days prior to randomization. The use of full dose anticoagulants is allowed as long as the INR or PTT is within therapeutic limits (according to the medical standard in the institution) and the patient has been on a stable dose for anticoagulants for at least three weeks at the time of inclusion

7. AST (SGOT)/ALT (SGPT) ≤ 2.5 x institutional ULN unless liver metastases are present, in which case it must be ≤ 5x ULN

8. Serum Creatinine ≤ 1.5 x ULN and a calculated creatinine clearance rate ≥ 60 mL /min

11. Female patients defined as women of childbearing potential (WOCBP) or male patients with WOCBP partners must agree to remain abstinent (refrain from heterosexual intercourse) or use contraceptive methods that result in a failure rate of <1% per year during the treatment period and for at least 6 months after the last dose of chemotherapy or for at least 3 months after last dose of durvalumab, whatever happens last. Male patients must refrain from donating sperm during this same period. Male patients with a pregnant partner must agree to remain abstinent or to use a condom for the duration of the pregnancy.

1. Patients with grade ≥ 2 neuropathy will be evaluated on a case-by-case basis after consultation with the Lead Investigator

2. Patients with irreversible toxicity not reasonably expected to be exacerbated by treatment with durvalumab may be included only after consultation with the Lead Investigator.

8. Patient had a prior allogeneic bone marrow transplantation or prior solid organ transplantation.

9. Patient has active or history of autoimmune or inflammatory disorders (including, but not limited to, inflammatory bowel disease [e.g., colitis or Crohn's disease], diverticulitis [with the exception of diverticulosis], systemic lupus erythematosus, Sarcoidosis syndrome, or Wegener syndrome [granulomatosis with polyangiitis, Graves' disease, rheumatoid arthritis, hypophysitis, uveitis]) . The following are exceptions:

1. Patients with vitiligo or alopecia

2. Patients with hypothyroidism (e.g. following Hashimoto syndrome) stable on hormone replacement

3. Patients with any chronic skin condition that does not require systemic therapy

4. Patients with celiac disease controlled by diet alone

5. Patients without active disease in the last 5 years may be included but only after consultation with the Lead Investigator

10. Uncontrolled intercurrent illness, including but not limited to, ongoing or active infection, symptomatic congestive heart failure, uncontrolled hypertension, unstable angina pectoris, cardiac arrhythmia, interstitial lung disease, serious chronic gastrointestinal conditions associated with diarrhea, or psychiatric illness/social situations that would limit compliance with study requirement, substantially increase risk of incurring AEs or compromise the ability of the patient to give written informed consent

Exclusion Criteria

1. Patient received previous or simultaneous endobiliary treatment other than RFA (e.g. PDT or brachytherapy)

2. Patient received previous systemic therapy with a PD-1, PD-L1 inhibitor (including durvalumab) or CTLA4 inhibitor or classical chemotherapy agents like platinum, fluoropyrimidine or gemcitabine-based regimens.

3. Patient receives any concurrent chemotherapy, investigational product or hormonal therapy for cancer treatment. Concurrent use of hormonal therapy for non-cancer related conditions (e.g., hormone replace therapy) is acceptable.

4. Patient has known hypersensitivity to any component of the durvalumab formulation as well as a known history of severe allergic, anaphylactic, or other hypersensitivity reactions to chimeric or humanized antibodies or fusion protein and/or any known contraindication (including hypersensitivity) to gemcitabine or cisplatin.

5. Patient has history of primary immunodeficiency

6. Patient has stage B cirrhosis according to Child-Pugh criteria (or worse) or cirrhosis (of any grade) with a history of hepatic encephalopathy or clinically significant ascites resulting from cirrhosis. Clinically significant ascites is defined as ascites resulting from cirrhosis requiring diuretics or paracentesis.

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Universitätsklinikum Düsseldorf, Germany

UNKNOWN

Sponsor Role: collaborator

Universitätsklinikum Köln

OTHER

Sponsor Role: collaborator

AstraZeneca

INDUSTRY

Sponsor Role: collaborator

Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Salah-Eddin SE Al-Batran, Prof. Dr.

Role: STUDY_CHAIR

Frankfurter Institut fuer Klinische Krebsforschung IKF GmbH

Locations

Uniklinik RWTH Aachen

Aachen, , Germany

Site Status: RECRUITING

Universitätsklinikum Bonn

Bonn, , Germany

Site Status: RECRUITING

Universitätsklinikum Köln

Cologne, , Germany

Site Status: RECRUITING

Universitätsklinikum Düsseldorf

Düsseldorf, , Germany

Site Status: RECRUITING

Krankenhaus Nordwest

Frankfurt, , Germany

Site Status: RECRUITING

Universitätsmedizin Göttingen

Göttingen, , Germany

Site Status: RECRUITING

Medizinische Hochschule Hannover

Hanover, , Germany

Site Status: RECRUITING

UKSH Campus Lübeck

Lübeck, , Germany

Site Status: RECRUITING

Universitaetsmedizin der Johannes Gutenberg-Universitaet Mainz

Mainz, , Germany

Site Status: RECRUITING

Universitätsklinik Münster

Münster, , Germany

Site Status: NOT_YET_RECRUITING

Countries

Germany

Central Contacts

Christoph Roderburg, Prof. Dr.

Role: CONTACT

christoph.roderburg@med.uni-duesseldorf.de

+49 211 8108030

Johanna Riedel, Dr.

Role: CONTACT

clean-duct@ikf-khnw.de

+49 69 5899 787 ext. 57

Facility Contacts

Cennet Sahin, Dr.

Role: primary

Maria Gonzales-Carmona, Prof. Dr.

Role: primary

Dirk Waldschmidt, Dr.

Role: primary

Christoph Roderburg, Prof. Dr.

Role: primary

Thorsten O Goetze, Prof. Dr.

Role: primary

goetze.thorsten@khnw.de

Johanna Reinecke, Dr.

Role: primary

Anna Saborowski, PD Dr.

Role: primary

Jens Marquardt, Prof. Dr.

Role: primary

Friedrich Foerster, PD Dr.

Role: primary

Jonel Trebicka, Prof. Dr. Dr.

Role: primary

Other Identifiers

2023-509165-21-00

Identifier Type: CTIS

Identifier Source: secondary_id

ESR-23-22156

Identifier Type: OTHER_GRANT

Identifier Source: secondary_id

IKF-t070

Identifier Type: OTHER

Identifier Source: secondary_id

CLEAN-DUCT / TRITICC-3

Identifier Type: -

Identifier Source: org_study_id