Real World Evidence in China: Faricimab Use in Diabetic Macular Edema, Retinal Vein Occlusion, and Neovascular Age-Related Macular Degeneration (The Farseeing Study)

NCT ID: NCT06439576

Last Updated: 2025-11-17

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Total Enrollment

1000 participants

Study Classification

OBSERVATIONAL

Study Start Date

2024-05-09

Study Completion Date

2027-11-15

Brief Summary

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The Farseeing Study will explore long-term effectiveness, safety, and treatment patterns among patients being treated with faricimab in real-world, routine clinical practice in China. It is a primary data collection, non-interventional, prospective and retrospective, multi-center study designed to collect real-world, long-term data to gain clinical evidence on faricimab, by observing cohorts of patients with neovascular age-related macular degeneration (nAMD), diabetic macular edema (DME), and retinal vein occlusion (RVO) who are receiving treatment with faricimab.

Detailed Description

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Conditions

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Diabetic Macular Edema Neovascular Age-related Macular Degeneration Retinal Vein Occlusion

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Cohort 1: Patients with nAMD

Faricimab

Intervention Type DRUG

The dosing and treatment duration of the studied medicinal product is at the discretion of the physician in accordance with clinical practice and labeling in China.

Cohort 2: Patients with DME

Faricimab

Intervention Type DRUG

The dosing and treatment duration of the studied medicinal product is at the discretion of the physician in accordance with clinical practice and labeling in China.

Cohort 3: Patients with RVO

Faricimab

Intervention Type DRUG

The dosing and treatment duration of the studied medicinal product is at the discretion of the physician in accordance with clinical practice and labeling in China.

Interventions

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Faricimab

The dosing and treatment duration of the studied medicinal product is at the discretion of the physician in accordance with clinical practice and labeling in China.

Intervention Type DRUG

Other Intervention Names

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VABYSMO®

Eligibility Criteria

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Inclusion Criteria

1. Have signed the informed consent
2. Female and male Chinese patients, who had been diagnosed with nAMD, DME, or RVO by CFP, OCT, FFA, ICGA, or OCTA
3. ≥50 years old for patients with nAMD, ≥18 years old both for patients with DME and RVO, at the time of signing informed consent (or the first administration of faricimab, whichever occurs first)
4. Patients for whom the decision to receive treatment with faricimab is made prior to and independent from study participation
5. Patients have received at least one faricimab treatment (the first dose) in the study eye

Exclusion Criteria

1. Patients not receiving treatment for nAMD/DME/RVO with faricimab according to the standard of care and in line with the current summary of product characteristics (SPC) / labeling in China
2. Active ocular inflammation or suspected / active ocular infection in either eye
3. Received any other anti-VEGF treatment after faricimab
4. Received any steroid treatment within 6 months (180 days) before the first faricimab treatment in the study eye
5. Any participation in any other clinical trials currently
6. Patients could not provide the clinical data (visual acuity and OCT images) within 2 weeks (14 days) before receiving the initial faricimab injection
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Shanghai Roche Pharmaceutical Co., Ltd

UNKNOWN

Sponsor Role collaborator

Hoffmann-La Roche

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Clinical Trials

Role: STUDY_DIRECTOR

Hoffmann-La Roche

Locations

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Joint Shantou International Eye Center

Shantou, Guangdong, China

Site Status

The First Affiliated Hospital of Henan UN of Science and Technology

Luoyang, Henan, China

Site Status

Taihe Hospital of Shiyan

Shiyan, Hubei, China

Site Status

Xuzhou No.1 Peoples Hospital

Xuzhou, Jiangsu, China

Site Status

Fushun Eye Hospital

Fushun, Liaoning, China

Site Status

Panjin Central Hospital

Panjin, Liaoning, China

Site Status

The First Hospital of China Medical University

Shenyang, Liaoning, China

Site Status

Affiliated Hospital of Shandong Second Medical University

Weifang, Shandong, China

Site Status

Shanghai General Hospital

Shanghai, Shanghai Municipality, China

Site Status

The First People's Hospital of Chengdu

Chengdu, Sichuan, China

Site Status

The First People's Hospital of Kashgar

Kashgar, Xinjiang Uygur, China

Site Status

The First People's Hospital of Yunnan Province

Kunming, Yun'nan, China

Site Status

Jinhua municipal central hospital

Jinhua, Zhejiang, China

Site Status

Peking University People's Hospital

Beijing, , China

Site Status

Sichuan Provincial People's Hospital

Chengdu, , China

Site Status

People's Hospital of Dingzhou

Dingzhou, , China

Site Status

Dongyang People's Hospital

Dongyang, , China

Site Status

Zhongshan Ophthalmic Center, Sun Yat-sen University

Guangzhou, , China

Site Status

Guizhou Provincial People's Hospital

Guiyang, , China

Site Status

Eye Hospital of Shandong First Medical University

Jinan, , China

Site Status

The First Affiliated Hospital of Lanzhou University

Lanzhou, , China

Site Status

The Affiliated Hospital of Southwest Medical University, Zhongshan Campus

Luzhou, , China

Site Status

Jiangsu Province Hospital (the First Affiliated Hospital With Nanjing Medical University)

Nanjing, , China

Site Status

The People?s Hospital of Guangxi Zhuang Autonomous Region

Nanning, , China

Site Status

Qingdao Eye Hospital of Shandong First Medical University

Qingdao, , China

Site Status

Ruijin Hospital Shanghai Jiaotong University School of Medicine

Shanghai, , China

Site Status

Shanghai Tenth People's Hospital

Shanghai, , China

Site Status

Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine

Shanghai, , China

Site Status

Shanghai Zhoupu Hospital

Shanghai, , China

Site Status

Shenyang Fourth People's Hospital

Shenyang, , China

Site Status

Shenzhen Eye Hospital

Shenzhen, , China

Site Status

Hebei People's Hospital

Shijiazhuang, , China

Site Status

Shanxi Bethune Hospital

Taiyuan, , China

Site Status

Tianjin Eye Hospital

Tianjin, , China

Site Status

Eye Hospital, Wenzhou Medical University

Wenzhou, , China

Site Status

Xiehe Hospital, Tongji Medical College Huazhong University of Science & Technology

Wuhan, , China

Site Status

Tongji Hospital Tongji Medical College Huazhong University of Science and Technology

Wuhan, , China

Site Status

Xiamen Eye Center Of Xiamen University

Xiamen, , China

Site Status

Hebei Eye Hospital

Xingtai, , China

Site Status

Henan Provincial Eye Hosptial

Zhengzhou, , China

Site Status

Affiliated Hospital of Zunyi Medical University

Zunyi, , China

Site Status

Countries

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China

Other Identifiers

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ML45401

Identifier Type: -

Identifier Source: org_study_id

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