A Study of Brepocitinib in Adults With Active, Non-Infectious, Non-Anterior Uveitis

NCT ID: NCT06431373

Last Updated: 2026-01-12

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

ACTIVE_NOT_RECRUITING

Clinical Phase

PHASE3

Total Enrollment

371 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-09-11

Study Completion Date

2028-02-01

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The purpose of this study is to determine the safety and efficacy of brepocitinib in participants with active, non-anterior (intermediate, posterior, or pan) non-infectious uveitis (NIU).

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Uveitis, Posterior Uveitis, Intermediate Uveitis

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Arm 1

Group Type EXPERIMENTAL

Brepocitinib PO QD

Intervention Type DRUG

Brepocitinib PO QD

Arm 2

Group Type PLACEBO_COMPARATOR

Placebo PO QD

Intervention Type DRUG

Placebo PO QD

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Brepocitinib PO QD

Brepocitinib PO QD

Intervention Type DRUG

Placebo PO QD

Placebo PO QD

Intervention Type DRUG

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Adult subjects (18-75 years old)
* Diagnosis of non-infectious uveitis (intermediate uveitis, posterior uveitis, or panuveitis)
* Active uveitic disease in at least 1 eye
* Weight \> 40 kg with a body mass index ≤ 40 kg/m2

Exclusion Criteria

Has confirmed or suspected current diagnosis of infectious uveitis History of or have:

1. Lymphoproliferative disorder
2. active malignancy
3. cancer within 5 years prior to screening (exceptions for basal cell carcinoma, squamous cell carcinoma, ductal carcinoma in situ of the breast, carcinoma in situ of the uterine cervix, or thyroid carcinoma.)
4. thrombosis or cerebrovascular ischemic event disease within the last 12 months
5. a high risk for herpes zoster reactivation
6. active or recent infections
Minimum Eligible Age

18 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Priovant Therapeutics, Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Responsibility Role SPONSOR

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Clinical Trial Site

Phoenix, Arizona, United States

Site Status

Clinical Trial Site

Phoenix, Arizona, United States

Site Status

Clinical Trial Site

Bakersfield, California, United States

Site Status

Clinical Trial Site

Beverly Hills, California, United States

Site Status

Clinical Trial Site

Fullerton, California, United States

Site Status

Clinical Trial Site

Irvine, California, United States

Site Status

Clinical Trial Site

La Jolla, California, United States

Site Status

Clinical Trial Site

Los Angeles, California, United States

Site Status

Clinical Trial Site

Los Angeles, California, United States

Site Status

Clinical Trial Site

Modesto, California, United States

Site Status

Clinical Trial Site

Sacramento, California, United States

Site Status

Clinical Trial Site

Aurora, Colorado, United States

Site Status

Clinical Trial Site

Denver, Colorado, United States

Site Status

Clinical Trial Site

Fort Lauderdale, Florida, United States

Site Status

Clinical Trial Site

St. Petersburg, Florida, United States

Site Status

Clinical Trial Site

Chicago, Illinois, United States

Site Status

Clinical Trial Site

Oak Park, Illinois, United States

Site Status

Clinical Trial Site

Carmel, Indiana, United States

Site Status

Clinical Trial Site

Prairie Village, Kansas, United States

Site Status

Clinical Trial Site

Baltimore, Maryland, United States

Site Status

Clinical Trial Site

Boston, Massachusetts, United States

Site Status

Clinical Trial Site

Waltham, Massachusetts, United States

Site Status

Clinical Trial Site

Ann Arbor, Michigan, United States

Site Status

Clinical Trial Site

Detroit, Michigan, United States

Site Status

Clinical Trial Site

Detroit, Michigan, United States

Site Status

Clinical Trial Site

Minneapolis, Minnesota, United States

Site Status

Clinical Trial Site

Rochester, Minnesota, United States

Site Status

Clinical Trial Site

St Louis, Missouri, United States

Site Status

Clinical Trial Site

Omaha, Nebraska, United States

Site Status

Clinical Trial Site

Palisades Park, New Jersey, United States

Site Status

NYU Langone Health

New York, New York, United States

Site Status

Clinical Trial Site

Rochester, New York, United States

Site Status

Clinical Trial Site

Durham, North Carolina, United States

Site Status

Clinical Trial Site

Winston-Salem, North Carolina, United States

Site Status

Clinical Trial Site

Cleveland, Ohio, United States

Site Status

Clinical Trial Site

Cleveland, Ohio, United States

Site Status

Clinical Trial Site

Columbus, Ohio, United States

Site Status

Clinical Trial Site

Portland, Oregon, United States

Site Status

Clinical Trial Site

Portland, Oregon, United States

Site Status

Clinical Trial Site

Erie, Pennsylvania, United States

Site Status

Clinical Trial Site

Philadelphia, Pennsylvania, United States

Site Status

Clinical Trial Site

Philadelphia, Pennsylvania, United States

Site Status

Clinical Trial Site

Greenville, South Carolina, United States

Site Status

Clinical Trial Site

Nashville, Tennessee, United States

Site Status

Clinical Trial Site

Austin, Texas, United States

Site Status

Clinical Trial Site

Bellaire, Texas, United States

Site Status

Clinical Trial Site

Dallas, Texas, United States

Site Status

Clinical Trial Site

Houston, Texas, United States

Site Status

Clinical Trial Site

Katy, Texas, United States

Site Status

Clinical Trial Site

Plano, Texas, United States

Site Status

Clinical Trial Site

Round Rock, Texas, United States

Site Status

Clinical Trial Site

San Antonio, Texas, United States

Site Status

Clinical Trial Site

Madison, Wisconsin, United States

Site Status

Clinical Trial Site

Rosario, Santa Fe Province, Argentina

Site Status

Clinical Trial Site

Buenos Aires, , Argentina

Site Status

Clinical Trial Site

Buenos Aires, , Argentina

Site Status

Clinical Trial Site

Buenos Aires, , Argentina

Site Status

Clinical Trial Site

Buenos Aires, , Argentina

Site Status

Clinical Trial Site

Sydney, New South Wales, Australia

Site Status

Clinical Trial Site

East Melbourne, Victoria, Australia

Site Status

Clinical Trial Site

Nedlands, Western Australia, Australia

Site Status

Clinical Trial Site

Linz, , Austria

Site Status

Clinical Trial Site

Leuven, VI-Brabant, Belgium

Site Status

Clinical Trial Site

Prague, , Czechia

Site Status

Clinical Trial Site

Mannheim, Baden-Wurttemberg, Germany

Site Status

Clinical Trial Site

Bonn, North Rhine-Westphalia, Germany

Site Status

Clinical Trial Site

Düsseldorf, North Rhine-Westphalia, Germany

Site Status

Clinical Trial Site

Münster, North Rhine-Westphalia, Germany

Site Status

Clinical Trial Site

Münster, North Rhine-Westphalia, Germany

Site Status

Clinical Trial Site

Kiel, , Germany

Site Status

Clinical Trial Site

Mainz, , Germany

Site Status

Clinical Trial Site

Thessaloniki, , Greece

Site Status

Clinical Trial Site

Pécs, Baranya, Hungary

Site Status

Clinical Trial Site

Debrecen, Hajdú-Bihar, Hungary

Site Status

Clinical Trial Site

Budapest, Pest County, Hungary

Site Status

Clinical Trial Site

Budapest, , Hungary

Site Status

Clinical Trial Site

Ashkelon, , Israel

Site Status

Clinical Trial Site

Haifa, , Israel

Site Status

Clinical Trial Site

Haifa, , Israel

Site Status

Clinical Trial Site

Holon, , Israel

Site Status

Clinical Trial Site

Jerusalem, , Israel

Site Status

Clinical Trial Site

Jerusalem, , Israel

Site Status

Clinical Trial Site

Kfar Saba, , Israel

Site Status

Clinical Trial Site

Poria – Neve Oved, , Israel

Site Status

Clinical Trial Site

Tel Aviv, , Israel

Site Status

Clinical Trial Site

Tel Aviv, , Israel

Site Status

Clinical Trial Site

Perugia, Umbria, Italy

Site Status

Clinical Trial Site

Milan, , Italy

Site Status

Clinical Trial Site

Reggio Emilia, , Italy

Site Status

Clinical Trial Site

Roma, , Italy

Site Status

Clinical Trial Site

Barcelona, Catalonia, Spain

Site Status

Clinical Trial Site

Barcelona, , Spain

Site Status

Clinical Trial Site

Madrid, , Spain

Site Status

Clinical Trial Site

Madrid, , Spain

Site Status

Clinical Trial Site

Valladolid, , Spain

Site Status

Clinical Trial Site

London, England, United Kingdom

Site Status

Clinical Trial Site

London, England, United Kingdom

Site Status

Clinical Trial Site

Maidstone, Kent, United Kingdom

Site Status

Clinical Trial Site

Middlesbrough, North Yorkshire, United Kingdom

Site Status

Clinical Trial Site

Oxford, Oxfordshire, United Kingdom

Site Status

Clinical Trial Site

Sheffield, South Yorkshire, United Kingdom

Site Status

Clinical Trial Site

Birmingham, West Midlands, United Kingdom

Site Status

Clinical Trial Site

Bradford, Yorkshire, United Kingdom

Site Status

Clinical Trial Site

Birmingham, , United Kingdom

Site Status

Clinical Trial Site

Bristol, , United Kingdom

Site Status

Clinical Trial Site

Liverpool, , United Kingdom

Site Status

Clinical Trial Site

Manchester, , United Kingdom

Site Status

Countries

Review the countries where the study has at least one active or historical site.

United States Argentina Australia Austria Belgium Czechia Germany Greece Hungary Israel Italy Spain United Kingdom

Related Links

Access external resources that provide additional context or updates about the study.

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

PVT-2201-303

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.