Hyaluronic Acid Delivery: CO2 Laser Versus Thulium Laser Treatment

NCT ID: NCT06431282

Last Updated: 2024-05-28

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

30 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-02-20

Study Completion Date

2024-06-30

Brief Summary

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* Weakly crossed-linked hyaluronic acid (HA) can be delivered through multiple injections into the dermal and subnormal layer to improve skin quality. However, this treatment comes with multiple bumps for several days.
* Alternatively, HA can be delivered after CO2 laser or thulium laser pretreatment. As microscopic analysis after this treatment is limited, the object of the present study is to investigate the morphological cellular changes after CO2 laser and thulium laser delivered HA into human skin.

Detailed Description

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Conditions

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Aging Skin

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

OTHER

Blinding Strategy

SINGLE

Participants

Study Groups

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CO2 laser + HA

Probands are treated with a CO2 laser. Afterwards a HA gel will be applied.

Group Type ACTIVE_COMPARATOR

CO2 laser + HA

Intervention Type OTHER

Probands will be treated with a CO2 laser. Afterwards a HA gel will be applied. To measure microscopic cellular changes, a multiphoton tomography will be used.

Thulium laser + HA

Probands are treated with a thulium laser. Afterwards a HA gel will be applied.

Group Type ACTIVE_COMPARATOR

Thulium laser + HA

Intervention Type OTHER

Probands will be treated with a thulium laser. Afterwards a HA gel will be applied. To measure microscopic cellular changes, a multiphoton tomography will be used.

Interventions

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CO2 laser + HA

Probands will be treated with a CO2 laser. Afterwards a HA gel will be applied. To measure microscopic cellular changes, a multiphoton tomography will be used.

Intervention Type OTHER

Thulium laser + HA

Probands will be treated with a thulium laser. Afterwards a HA gel will be applied. To measure microscopic cellular changes, a multiphoton tomography will be used.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

\- healthy male and female patients

Exclusion Criteria

* pregnancy, breast feeding
* open wounds at the area to be treated
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Universitätsklinikum Hamburg-Eppendorf

OTHER

Sponsor Role lead

Responsible Party

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Lynhda Nguyen

Principle Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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University Medical-Center Hamburg-Eppendorf

Hamburg, , Germany

Site Status RECRUITING

Countries

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Germany

Facility Contacts

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Lynhda Nguyen, Dr. med.

Role: primary

+49 (0)40 7410-0

References

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Nguyen L, Mess C, Schneider SW, Huck V, Herberger K. In vivo visualisation of tattoo particles using multiphoton tomography and fluorescence lifetime imaging. Exp Dermatol. 2022 Nov;31(11):1712-1719. doi: 10.1111/exd.14646. Epub 2022 Jul 25.

Reference Type BACKGROUND
PMID: 35837813 (View on PubMed)

Other Identifiers

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01-24

Identifier Type: -

Identifier Source: org_study_id

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