Dynamic Whole-body PET/CT Imaging in Clinical Oncology

NCT ID: NCT06424873

Last Updated: 2024-05-22

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

60 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-04-01

Study Completion Date

2025-12-31

Brief Summary

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The goal of this clinical trial is to to achieve robust quantitative whole- body parametric imaging in clinically feasible scan times in patient with oncologic pathology .

The main question\[s\] it aims to answer are:

* \[question 1\]
* \[question 2\] Participants will \[describe the main tasks participants will be asked to do, treatments they'll be given and use bullets if it is more than 2 items\].

Detailed Description

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Whole body hybrid PET/CT imaging, making use of the standardized uptake value (SUV), is well established in clinical setting for diagnosis and staging, treatment response monitoring and radiation therapy treatment planning of a wide range of oncologic malignancies. However, the SUV metric derived from static PET data does not capture the dynamics of the PET probe biodistribution in the body.

The present work proposes to fill in this notable gap: namely to merge whole-body and dynamic PET/CT imaging, to achieve robust quantitative whole- body parametric imaging in clinically feasible scan times. Our proposed approach has the potential to significantly enhance diagnostic, prognostic and treatment response monitoring capabilities of PET/CT and to fundamentally alter routine clinical practice.

Conditions

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Cancer

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

PET/CT
Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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One arm study

Additionnal images during PET/CT

Group Type EXPERIMENTAL

PET/CT with FDG or FES

Intervention Type RADIATION

The study consists of an additional 50 minutes of imaging during the radiotracer's uptake phase prior to their clinical scan (standard of care).

Interventions

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PET/CT with FDG or FES

The study consists of an additional 50 minutes of imaging during the radiotracer's uptake phase prior to their clinical scan (standard of care).

Intervention Type RADIATION

Eligibility Criteria

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Inclusion Criteria

1. Patients clinically indicated for whole-body PET evaluation.
2. Patient must agree to lie still in the camera.
3. Patient must be able to comply with study procedures.
4. Patient must be able to provide informed consent.

Exclusion Criteria

1. Patients \< 18 years of age.
2. Pregnant women are excluded.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Valentina Garibotto

OTHER

Sponsor Role lead

Responsible Party

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Valentina Garibotto

Head of the Division of Nuclear Medicine and Molecular imaging

Responsibility Role SPONSOR_INVESTIGATOR

Locations

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Geneva University Hospitals

Geneva, , Switzerland

Site Status RECRUITING

Countries

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Switzerland

Central Contacts

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Valentina Garibotto, Pr

Role: CONTACT

+41223727252

Ismini Mainta, Dr

Role: CONTACT

+41795534454

Facility Contacts

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Valentina Garibotto

Role: primary

Other Identifiers

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2023-02102

Identifier Type: -

Identifier Source: org_study_id

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