Prospective Clinical Trial for Children With TCRαβ Depleted vs Traditional Haplo Identicle HSCT
NCT ID: NCT06423131
Last Updated: 2024-05-29
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
110 participants
INTERVENTIONAL
2024-05-26
2028-03-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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NON_RANDOMIZED
PARALLEL
TREATMENT
NONE
Study Groups
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Traditional Haplo identicle HCT
Beijing haploidenticla HCT is the routinely traditional way used for haploidentical HCT
No interventions assigned to this group
TCRαβ Depleted haploidentical HCT
TCRαβ Depleted haploidentical HCT is experimental used to decrease GVHD and obtain better qulity of life for children with haploidentical HCT.
TCRαβ Depleted haploidentical HCT
Use the CliniMACS TCRα/β deplete from the mobilized peripheral blood stem cells of haploidentical donor in children
Interventions
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TCRαβ Depleted haploidentical HCT
Use the CliniMACS TCRα/β deplete from the mobilized peripheral blood stem cells of haploidentical donor in children
Eligibility Criteria
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Inclusion Criteria
* Children who meet the indicators haploidentical hematopoietic cell transplantation
* No HLA ≥ 9/10 donor or not suitable for this type of donor due to illness
* Informed consent must be signed (by the patient or legal representative)
Exclusion Criteria
* Chronic active viral hepatitis
* Ejection fraction \<50%
* Respiratory failure necessitating supplemental oxygen
* Patients with a history of psychiatric illness or a condition which could interfere with their ability to understand the requirements of the study
* Patients unwilling or unable to comply with the protocol or unable to give informed consent
* Concurrent severe or uncontrolled infection
8 Weeks
18 Years
ALL
No
Sponsors
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Sijia Gu
OTHER
Responsible Party
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Sijia Gu
Principal investigator
Principal Investigators
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Jing Chen, PhD
Role: PRINCIPAL_INVESTIGATOR
Shanghai Children's Medical Center
Locations
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Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University
Shanghai, Shanghai Municipality, China
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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SCMCIRB-K2024030-2
Identifier Type: -
Identifier Source: org_study_id
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