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Pesticides and Parkinson´s Disease

NCT ID: NCT06420310

Last Updated: 2024-05-20

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

260 participants

Study Classification

OBSERVATIONAL

Study Start Date

2024-04-01

Study Completion Date

2028-12-30

Brief Summary

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The aim of this project is to study whether people exposed to pesticides have a higher risk of developing PD. We will perform an epidemiological study determining the presence of pesticides in urine and comparing signs traditionally associated with PD in early forms.

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Detailed Description

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Within different risk factors, pesticide exposure increases the risk of developing Parkinson's disease (PD) through epigenetic mechanisms by modifying the expression of genes related to PD and secondary mitochondrial dysfunction.We will conduct a cross-sectional prevalence study with cases (exposed to pesticides) and controls (not exposed to pesticides), randomly selecting 130 individuals in each group. Pesticide exposure will be determined through questionnaires.We will study the prevalence of preclinical and prodromal PD based on pesticide exposure, stratified by age and gender in the exposed, and non-exposed groups. Preclinical and prodromal PD will be assessed using: biological biomarkers and prodromal PD signs. Multivariate analyses will be employed to determine the risk of presenting early PD, adjusting for different clinical covariates. The results of this study will allow us to understand the early mechanisms associated with neurodegeneration and pesticides exposure.

Conditions

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Pesticide-Induced Parkinsonism

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Cases

Subjects exposed to pesticides

exposure to pesticides

Intervention Type OTHER

based on work exposures to pesticides

Controls

Subjects without any exposure to pesticides

exposure to pesticides

Intervention Type OTHER

based on work exposures to pesticides

Interventions

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exposure to pesticides

based on work exposures to pesticides

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Farmers exposed to pesticides for cases
* No work exposure to pesticides for controls

Exclusion Criteria

* Subjects without signed consent form
* Neurological significant conditions
Minimum Eligible Age

45 Years

Maximum Eligible Age

55 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Hospital Universitario de Burgos

OTHER

Sponsor Role lead

Responsible Party

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Esther Cubo

MD, PhD

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Hospital Universitario de Burgos

Burgos, , Spain

Site Status RECRUITING

Countries

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Spain

Facility Contacts

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Esther Cubo, MD

Role: primary

[email protected]
+34947256533

Other Identifiers

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GRS 2682/A1/2023

Identifier Type: -

Identifier Source: org_study_id

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