Using Personalized Assessments in the Treatment of Childhood OCD

NCT ID: NCT06407648

Last Updated: 2025-05-18

Basic Information

• Recruitment Status: RECRUITING
• Clinical Phase: NA
• Total Enrollment: 30 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2024-04-03
• Study Completion Date: 2026-12-30

Brief Summary

The primary purpose of this study is to learn whether personalized assessment of obsessive-compulsive disorder (OCD) symptoms in childhood OCD using mobile health technology are feasible and acceptable for youth and parents. The investigators will also examine whether personalized cognitive-behavioral therapy (CBT) that is informed by personalized OCD assessments yields better clinical outcomes when compared to standard CBT for youth with OCD

Conditions

Obsessive-Compulsive Disorder

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: SINGLE

Study Groups

Personalized Assessments

12 sessions of exposure with response prevention (ERP) that is guided by personalized assessments.

Group Type: EXPERIMENTAL

Personalized Assessments

Intervention Type: OTHER

Personalized CBT will use individualized OCD symptom networks to guide CBT strategies to target central symptom nodes in contemporaneous networks.

Standard of Care

12 sessions of exposure with response prevention (ERP) that is guided using standard practice.

Group Type: ACTIVE_COMPARATOR

Standard of Care

Intervention Type: OTHER

The standard CBT condition will use standard-of-care approaches to guide CBT strategies to target OCD symptoms.

Interventions

Personalized Assessments

Personalized CBT will use individualized OCD symptom networks to guide CBT strategies to target central symptom nodes in contemporaneous networks.

Intervention Type: OTHER

Standard of Care

The standard CBT condition will use standard-of-care approaches to guide CBT strategies to target OCD symptoms.

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

1. be 8-17 years of age;

2. meet diagnostic criteria for a primary diagnosis of OCD on a structured clinical interview;

3. have moderate OCD severity as evidenced by a CY-BOCS total score of ≥16;

4. medication free and/or on a stable dose of medication 8 weeks prior to study participation;

5. be English speaking.

Exclusion Criteria

1. the presence of psychotic disorder, bipolar disorder, or autism spectrum disorders;

2. significant suicidal ideation that warrants medical intervention;

3. concurrent psychotherapy for OCD;

4. inability to complete scales, or attend visits.

• Minimum Eligible Age: 8 Years
• Maximum Eligible Age: 17 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Johns Hopkins University

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Joseph F. McGuire, PhD

Role: PRINCIPAL_INVESTIGATOR

Johns Hopkins University

Locations

Johns Hopkins University School of Medicine

Baltimore, Maryland, United States

Site Status: RECRUITING

Countries

United States

Central Contacts

Alexandra Chang

Role: CONTACT

coach@jhmi.edu

443-300-8836

Lauren Browning

Role: CONTACT

coach@jhmi.edu

443-300-8836

Facility Contacts

Joseph McGuire, PhD

Role: primary

coach@jhmi.edu

443-287-7157

Other Identifiers

IRB00406231

Identifier Type: -

Identifier Source: org_study_id