PK/PD Study of SHR-2017 Injection in Patients With Bone Metastases

NCT ID: NCT06380881

Last Updated: 2025-11-18

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: PHASE1
• Total Enrollment: 25 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2024-05-20
• Study Completion Date: 2025-08-06

Brief Summary

To evaluate the pharmacokinetic characteristics, pharmacodynamic characteristics, safety, tolerability and immunogenicity of SHR-2017 injection in patients with bone metastases, and to evaluate the efficacy of SHR-2017 injection in the treatment of skeletal-related event and cancer pain.

Conditions

Patients With Bone Metastases

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

SHR-2017

Group Type: EXPERIMENTAL

SHR-2017

Intervention Type: DRUG

SHR-2017

Interventions

SHR-2017

SHR-2017

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

1. Able and willing to provide a written informed consent

2. Male or female, age ≥ 18 years;

3. Solid tumors confirmed by histological or cytological examination;

4. At least 1 bone metastasis from a documented tertiary A hospital during the screening period;

5. Worst pain score NRS ≥5 points when treated with a stable analgesic regimen during the baseline assessment period;

6. Received a stable anti-tumor regimen within 28 days prior to the baseline assessment period

7. During the screening period, the physical status score of the Eastern Cooperative Oncology Group (ECOG) was 0-2 points;

8. Life expectancy judged by the investigator to be at least 6 months

9. Good organ function during the screening period (repeated testing can be confirmed if necessary);

10. Female subjects of childbearing potential with negative blood pregnancy test results within 7 days prior to the first dose of study drug and not lactating.

Exclusion Criteria

1. Previous occurrence or concomitant osteomyelitis of the jaw or osteonecrosis of the jaw, dental disease or jaw disease that is active, requiring oral surgery, dental surgery or oral surgery wound that has not fully healed, or has planned invasive dental procedures during the study;

2. History of major joint trauma or surgery within 1 year prior to enrollment

3. Cardiac dysfunction Within 6 months before enrollment;

4. Resting tachycardia or resting bradycardia on ECG at screening；

5. Subjects who have evidence of orthostatic hypotension at screening；

6. Hepatitis B surface antigen (HBSAG), hepatitis C antibody (HCVAB), human immune defect antivirus (HIV) antibody, syphilis antibody;

7. The pain of the subjects not predominantly related to a bone metastasis;

8. The subject with neurological diseases and/or mental illness and/or cognitive dysfunction ；

9. Receipt of radiopharmaceutical treatment or radiotherapy for treatment of bone metastasis within 1 month of the treatment period, and the subject who received the radiotherapy within one month before the first research drug administration

10. Subject has a history of allergic or anaphylactic reaction to mammalian -based drugs, or allergies to supplements (calcium or vitamin D supplements), or have a history of allergens of opioids, or past history of treatment or diagnostic monoclonal antibody, Or other allergies;

11. The subject participated in the treatment of other clinical trials within one month before receiving the experimental drug (except for participating in other clinical trial screening losers);

12. In the judgment of the investigator, would make the subject inappropriate for entry into this study;

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Suzhou Suncadia Biopharmaceuticals Co., Ltd.

INDUSTRY

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

Beijing Cancer Hospital

Beijing, Beijing Municipality, China

Countries

China

Other Identifiers

SHR-2017-102

Identifier Type: -

Identifier Source: org_study_id