Developmental and Epileptic Encephalopathy of Genetic Etiology: Natural History Through Reuse of Clinical Data

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

400 participants

Study Classification

OBSERVATIONAL

Study Start Date

2024-10-31

Study Completion Date

2026-12-31

Brief Summary

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Developmental and Epileptic Encephalopathy (DEE) are a heterogeneous group of neurodevelopmental disorders linked to both epilepsy and its underlying etiology, independently of epileptiform activity.

The creation of a database with retrospective follow-up of a large number of patients on a national scale will enable better knowledge of specific biomarkers, and thus a better classification and understanding of the natural evolution of DEE according to their etiology. This will enable better, more personalized therapeutic management of patients, depending on etiology and the presence or absence of these biomarkers. The investigators will also be able to draw up management recommendations, which are currently non-existent.

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Detailed Description

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Conditions

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Developmental and Epileptic Encephalopathy

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

RETROSPECTIVE

Study Groups

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Patient

Patient inclusion criteria:

* Diagnosis of developmental and epileptic encephalopathies
* Affiliation with, or beneficiary of, a social security scheme

Criteria for non-inclusion of patients:

* Opposition of the patient or his/her parents in the case of minors to the re-use of data for this study.
* Persons subject to a safeguard of justice measure

No interventions assigned to this group

Control patient

Inclusion criteria for controls:

* Patients who, as part of their routine health care, require an EEG examination
* Patients with sufficient follow-up to rule out a diagnosis of epilepsy, including developmental and epileptic encephalopathies
* Enrolled in or receiving social security benefits

Criteria for non-inclusion of controls :

* Patient with a neurological or extra-neurological disease that may have an impact on the child's neurological development and outcome
* Opposition of the patient or his/her parents to the re-use of data for this study
* Persons subject to a safeguard of justice measure

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Diagnosis of Developmental and Epileptic Encephalopathy
* Registered with or benefiting from a social security scheme.

Exclusion Criteria

* Opposition of the patient or his/her parents to the re-use of data in the context of this study
* Person subject to a safeguard of justice measure

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Responsible Party

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Responsibility Role SPONSOR

Locations

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