Choline Metabolites in People With Prostate Cancer and Those With Benign Hyperplasia

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Total Enrollment

350 participants

Study Classification

OBSERVATIONAL

Study Start Date

2012-01-12

Study Completion Date

2015-11-30

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The aim of this study was to investigate plasma concentrations of one-carbon metabolites and phospholipid classes in participants with primary prostate cancer and those with benign hyperplasia. Moreover, the metabolites were studied in relation to tumor grade and age.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Assessment of Predictive Role of [11C] Choline PET/CT on Survival in Prostate Cancer Patients With Biochemical Failure Without Androgen Deprivation Therapy

NCT06167824

Prostate Cancer

COMPLETED

Cholecalciferol and Genistein Before Surgery in Treating Patients With Early Stage Prostate Cancer

NCT01325311

Prostate Adenocarcinoma Stage I Prostate Cancer Stage IIA Prostate Cancer +1 more

COMPLETED PHASE2

Nutrition and Prostate Cancer

NCT03532308

Prostate Cancer

TERMINATED PHASE3

Study of Treatment Choice in Patients With Localized Prostate Cancer

NCT01177865

Prostate Cancer

UNKNOWN NA

Determining Patterns In Trial Experiences of Recurrent Prostate Cancer Patients

NCT06070272

Recurrent Prostate Cancer

NOT_YET_RECRUITING

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

This observational study recruited participants with primary prostate cancer (cases) and those with benign hyperplasia (controls) before the surgery. Data on the outcomes of the surgery including the results of the biopsy investigation were collected. Blood samples were collected before the surgery in context of routine blood investigations. Blood plasma samples collected on ethylenediaminetetraacetic acid (EDTA) were used to measure concentrations of free choline, betaine, dimethylglycine, folate forms, S-adenosylhomocysteine, S-adenosylmethionine, homocysteine, cystathionine, and methylmalonic acid (MMA). Data on serum concentrations of prostate specific antigen (PSA) and the tumor grade and classification (Gleason Score system) were collected. The associations between the plasma concentrations of the metabolites and PSA or the Gleason score were studied. The concentrations of the metabolic markers were compared between the cases and the controls according to the age of the participants.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Primary Prostate Urothelial Cancer Benign Prostatic Hyperplasia

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

CASE_CONTROL

Study Time Perspective

CROSS_SECTIONAL

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Primary prostate cancer

Men participants diagnosed with primary prostate cancer are "cases"

Plasma concentration of choline

Intervention Type OTHER

The exposure in this observational study is plasma concentrations of choline

Benign hyperplasia

Men participants diagnosed with benign hyperplasia are the "controls"

Plasma concentration of choline

Intervention Type OTHER

The exposure in this observational study is plasma concentrations of choline

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Plasma concentration of choline

The exposure in this observational study is plasma concentrations of choline

Intervention Type OTHER

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Men participants
* age \> 50 years
* recently diagnosed with primary prostate cancer or benign hyperplasia

Exclusion Criteria

* vitamin B supplementation (folic acid\> 400 µg / day; B12\> 10 µg / day; B6\> 10 mg / day)
* renal failure
* advanced liver disease
* chronic alcohol consumption
* metastases
* methotrexate therapy.

Minimum Eligible Age

50 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

No