Boosting The Intervention Effect of Negative Memory Through tACS Stimulation

NCT ID: NCT06375395

Last Updated: 2024-08-07

Basic Information

• Recruitment Status: NOT_YET_RECRUITING
• Clinical Phase: NA
• Total Enrollment: 60 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2024-08-15
• Study Completion Date: 2024-12-31

Brief Summary

The objectives of this study include: 1) investigating the impact of negative memory substitution on an individual's other intellectual memories (i.e., neutral memories) and the underlying neurocognitive mechanisms; 2) investigating the memory enhancement effect resulting from retrieval practice associated with memory substitution intervention along with an examination of the neurocognitive mechanisms responsible for this enhancement.

Detailed Description

This study will adopt two memory updating strategies: retrieval practice and reactivation.

A 5-day memory updating experimental paradigm is used.

1. On the first day, the old memory A-B linkage is learned, where A represents a neutral word and B is either neutral or negative pictures (half of each, randomly scrambled).

2. On the second day, the old memory A-B association is consolidated again, and after a 15-minute break, the new memory A-C association is learned, where A is still the word A used in the old memory A-B association on the first day, and C is the new neutral and negative pictures (half of each, randomly scrambled, and with inconsistent categories of C and B in each pair of AC and AB). Immediately following this, the new memories of the A-C conjunctions are updated using both Retrieval practice and Restudy (control condition) memory strategies.

3. A-C is extracted/learned using both Retrieval practice and Restudy memory strategies on both day 3 and day 4.

4. On the fifth day, memory tests for associative memory strength, gist and detail memory, as well as emotional valence and strength are performed.

Conditions

Seizures

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: QUADRUPLE

Study Groups

Active tACS

Those who participate in the treatment group will receive tACS, which lasts for 40 minutes per day on 3 consecutive days.

Group Type: EXPERIMENTAL

Active tACS Device

Intervention Type: DEVICE

Transcranial Alternating Current Stimulation

Sham tACS

Those who participate in the control group will receive sham tACS, which lasts for 40 minutes per day on 3 consecutive days.

Group Type: PLACEBO_COMPARATOR

Sham tACS Device

Intervention Type: DEVICE

Placebo Device that simulates active tACS treatment

Interventions

Active tACS Device

Transcranial Alternating Current Stimulation

Intervention Type: DEVICE

Sham tACS Device

Placebo Device that simulates active tACS treatment

Intervention Type: DEVICE

Eligibility Criteria

Inclusion Criteria

1. 14-60 years old, male or female, Han Chinese;

2. Drug-resistant epilepsy;

3. Required surgical implantation of SEEG electrodes.

Exclusion Criteria

1. Progressive encephalopathy or progressive structural damage in the central nervous system;

2. Significant heart, liver, renal insufficiency, and other medical diseases;

3. Severe side effects from taking antiepileptic drugs at the time of enrollment and not inappropriate for SEEG;

4. Significant intellectual disability;

5. A history of alcohol and drug abuse;

6. Any contraindication to MRI.

• Minimum Eligible Age: 14 Years
• Maximum Eligible Age: 60 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Beijing Normal University

OTHER

Sponsor Role: collaborator

Xuanwu Hospital, Beijing

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Guoguang Zhao

Role: STUDY_DIRECTOR

Xuanwu Hospital, Beijing

Central Contacts

Hongxing Wang, MD & PhD

Role: CONTACT

hxwang8888@126.com

01083198513

Other Identifiers

Memory Updating Tasks

Identifier Type: -

Identifier Source: org_study_id