Effect of the Association of Berberine Fitosoma® and Monacolin K MonaKoPure® on Glyco-metabolic Parameters in Dysglycemic and Dyslipidemic Patients.

NCT ID: NCT06348550

Last Updated: 2024-04-04

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

120 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-11-30

Study Completion Date

2024-09-30

Brief Summary

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The objective of this study is to evaluate the effectiveness of the association Berberina Fitosoma® and monacolin K MonaKoPure® (Berberol® K supplement) compared to placebo on glucidic and lipid parameters in subjects with fasting blood glucose (FPG) values between 100 and 125 mg/dl and with total cholesterol (TC) values ≥ 200 mg/dl.

Detailed Description

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The objective of this study is to evaluate the effectiveness of the association Berberina Fitosoma® and monacolin K MonaKoPure® (Berberol® K supplement) compared to placebo on glucidic and lipid parameters in subjects with fasting blood glucose (FPG) values between 100 and 125 mg/dl and with total cholesterol (TC) values ≥ 200 mg/dl.

Conditions

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Dyslipidemias Dysglycemia

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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Active treatment

Group Type ACTIVE_COMPARATOR

Berberol® K

Intervention Type DIETARY_SUPPLEMENT

Nutraceutical containing an association of Berberine Fitosoma® and Monacolin K MonaKoPure®

Placebo treatment

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DIETARY_SUPPLEMENT

Placebo

Interventions

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Berberol® K

Nutraceutical containing an association of Berberine Fitosoma® and Monacolin K MonaKoPure®

Intervention Type DIETARY_SUPPLEMENT

Placebo

Placebo

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

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Inclusion Criteria

* Overweight or obese subjects \[according to body mass index (BMI)\]
* Fasting plasma glucose value between 100 and 125 mg/dl, with impaired fasting glucose or impaired glucose tolerance confirmed with oral glucose tolerance test (OGTT)
* Total cholesterol values ≥ 200 mg/dl

Exclusion Criteria

* Patients with neoplastic and liver diseases, renal failure
* Patients with type 1 or 2 diabetes mellitus
* Pregnant or breastfeeding women
* Hypersensitivity to any of the ingredients
* Therapy with lipid-lowering drugs
* Use of products containing red yeast rice
Minimum Eligible Age

18 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Fondazione IRCCS Policlinico San Matteo di Pavia

OTHER

Sponsor Role collaborator

University of Pavia

OTHER

Sponsor Role lead

Responsible Party

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Giuseppe Derosa

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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IRCCS Policlinico S. Matteo Foundation

Pavia, , Italy

Site Status RECRUITING

Countries

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Italy

Central Contacts

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Giuseppe Derosa

Role: CONTACT

+390382502614

Facility Contacts

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Giuseppe Derosa, MD, PhD

Role: primary

Pamela Maffioli, MD

Role: backup

Other Identifiers

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BFMKP 01

Identifier Type: -

Identifier Source: org_study_id

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