The Efficacy of Dexmedetomidine Versus Labetalol In Providing Controlled Hypotension In Dacryocystorhinostomy SurgeryA Comparative Randomized Prospective Study
NCT ID: NCT06346561
Last Updated: 2024-04-04
Study Results
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Basic Information
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RECRUITING
NA
50 participants
INTERVENTIONAL
2024-03-30
2024-08-30
Brief Summary
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The proposed treatment in this regard is dacryocystorhinostomy (DCR) surgery. Therefore, hemostasis is of great significance in performing DCR surgery. In this regard, the reduction of controlled hypotension and the control of hemodynamic responses of the body to stress effectively reduce the bleeding volume during surgery.
Hence, there is no enough studies about controlled hypotension in DCR we decided to perform such a comparison between the effect of dexmedetomidine and labetalol in providing controlled hypotension during DCR surgery.
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
NONE
Study Groups
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Dexmedetomidine group
Dexmedetomidine
the reduction of controlled hypotension and the control of hemodynamic responses of the body
Labetalol
the reduction of controlled hypotension and the control of hemodynamic responses of the body
Labetalol group
Dexmedetomidine
the reduction of controlled hypotension and the control of hemodynamic responses of the body
Labetalol
the reduction of controlled hypotension and the control of hemodynamic responses of the body
Interventions
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Dexmedetomidine
the reduction of controlled hypotension and the control of hemodynamic responses of the body
Labetalol
the reduction of controlled hypotension and the control of hemodynamic responses of the body
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* Allergy to any of the drug included in this study.
18 Years
60 Years
ALL
Yes
Sponsors
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Sohag University
OTHER
Responsible Party
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Mohamed Aboesoud Mahmoud
Resident of Anesthesia, Intensive Care and Pain management Sohag university hospital.
Locations
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Sohag University hospitals
Sohag, , Egypt
Countries
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Central Contacts
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Elhadad A Mousa, Professor
Role: CONTACT
Facility Contacts
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Magdy M Amin, Professor
Role: primary
References
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Vinciguerra A, Nonis A, Resti AG, Bussi M, Trimarchi M. Impact of Post-Surgical Therapies on Endoscopic and External Dacryocystorhinostomy: Systematic Review and Meta-Analysis. Am J Rhinol Allergy. 2020 Nov;34(6):846-856. doi: 10.1177/1945892420945218. Epub 2020 Jul 23.
Heindl LM, Junemann AG, Kruse FE, Holbach LM. Tumors of the lacrimal drainage system. Orbit. 2010 Oct;29(5):298-306. doi: 10.3109/01676830.2010.492887.
Degoute CS, Dubreuil C, Ray MJ, Guitton J, Manchon M, Banssillon V, Saumet JL. Effects of posture, hypotension and locally applied vasoconstriction on the middle ear microcirculation in anaesthetized humans. Eur J Appl Physiol Occup Physiol. 1994;69(5):414-20. doi: 10.1007/BF00865405.
Alicandri-Ciufelli M, Pingani L, Maccarrone F, Anschuetz L, Mariano D, Galeazzi GM, Presutti L, Molinari G. Validation of the Modena bleeding score in endoscopic sinus surgery. Braz J Otorhinolaryngol. 2022 Jul-Aug;88(4):602-606. doi: 10.1016/j.bjorl.2020.08.006. Epub 2020 Sep 30.
Rahimzadeh P, Faiz SH, Alebouyeh MR. Effects of premedication with metoprolol on bleeding and induced hypotension in nasal surgery. Anesth Pain Med. 2012 Winter;1(3):157-61. doi: 10.5812/kowsar.22287523.3408. Epub 2012 Jan 1.
Other Identifiers
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Soh-Med-24-02-10MS
Identifier Type: -
Identifier Source: org_study_id
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