Optimal Attained LDL-Cholesterol Levels in Patients Who Achieved ≥50% LDL Reduction After PCI

NCT ID: NCT06338956

Last Updated: 2025-05-21

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

135877 participants

Study Classification

OBSERVATIONAL

Study Start Date

2024-01-01

Study Completion Date

2025-05-15

Brief Summary

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For the management of low-density lipoprotein-cholesterol (LDL-C), some guidelines recommend initial statin treatment with high-intensity statins to achieve at least a 50% reduction in LDL-C levels. High-intensity or maximally tolerated intensity can be maintained without a target goal. However, the European guideline recommends less than 55 mg/dL of LDL-C after PCI.

Detailed Description

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To investigate the Optimal Attained LDL-C Levels in Patients Who Achieved ≥50% LDL-C Reduction After PCI.

Conditions

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Coronary Artery Disease Hyperlipidemias

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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>=50% LDL-C reduction

LDL-C reduction \>=50%

Further divided by LDL \<55mg/dL 55\< LDL \< 70 mg/dL LDL \> 70 mg/dL

LDL reduction therapy

Intervention Type DRUG

LDL reduction therapy

<50% LDL-C reduction

LDL-C reduction \<50%

LDL reduction therapy

Intervention Type DRUG

LDL reduction therapy

Interventions

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LDL reduction therapy

LDL reduction therapy

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Patients receiving PCI with health check up before and after PCI within 3 years

Exclusion Criteria

* Patients receiving statin before PCI
* Patients with liver cirrhosis
* Patients with cancer
* Patients without prescription of statin
* Patients with LDL-C \<55 mg/dL before PCI
Minimum Eligible Age

19 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Samsung Medical Center

OTHER

Sponsor Role lead

Responsible Party

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Ki Hong Choi

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Samsung Medical Center

Seoul, , South Korea

Site Status

Countries

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South Korea

References

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Kang D, Choi KH, Yang S, Kim H, Park TK, Lee JM, Cho J, Yang JH, Song YB, Choi SH, Gwon HC, Hahn JY. Clinical significance of low-density lipoprotein cholesterol percentage reduction and attained levels after percutaneous coronary intervention. CMAJ. 2025 Apr 27;197(16):E442-E452. doi: 10.1503/cmaj.241713.

Reference Type DERIVED
PMID: 40294950 (View on PubMed)

Other Identifiers

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Lipid-PCI

Identifier Type: -

Identifier Source: org_study_id

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