Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
PHASE4
30 participants
INTERVENTIONAL
2025-04-28
2026-05-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
PREVENTION
NONE
Study Groups
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Standard of Care
Standard of care
Nitrofurantoin
administered PO
Experimental
Gentamicin
Gentamicin
administered via bladder
Interventions
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Nitrofurantoin
administered PO
Gentamicin
administered via bladder
Eligibility Criteria
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Inclusion Criteria
* 2 UTIs in 6 months
* desire to start antibiotic prophylaxis to prevent UTIs
Exclusion Criteria
* myasthenia gravis
* renal failure
* liver failure
* bladder pain syndrome
* multiple negative urine cultures associated with UTI symptoms (\>/= 3)
* bladder Botox treatments in the past
* treatment planned for UI and prolapse
* unevaluated microscopic hematuria
* history of kidney stones
* no antibiotics within 4 weeks
* most recent weight \<40kg (88.18lbs)
* surgically altered urinary tract (urinary diversion, phalloplasty, etc)
* allergy or hypersensitivity to either of the study medications or medications in the same family including but not limited to: amikacin, kanamycin, neomycin, paromomycin, streptomycin, tobramycin.
40 Years
FEMALE
Yes
Sponsors
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Women and Infants Hospital of Rhode Island
OTHER
Responsible Party
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Locations
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Women & Infants Hospital
Providence, Rhode Island, United States
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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2126175 // CTR grant U54GM1156
Identifier Type: -
Identifier Source: org_study_id
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