The Effect of a Ketone Drink on Blood Glucose Levels in People With Type 2 Diabetes
NCT ID: NCT06324669
Last Updated: 2025-04-18
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
15 participants
INTERVENTIONAL
2024-03-16
2025-01-26
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
CROSSOVER
BASIC_SCIENCE
QUADRUPLE
Study Groups
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Ketone supplementation
100 mL flavoured drink containing 0.3 g/kg ketone monoester ((R)-3-hydroxybutyl (R)-3-hydroxybutyrate; ΔG®, University of Oxford; https://www.deltagketones.com)
Ketone supplement
100 mL flavoured drink containing 0.3 g/kg ketone monoester ((R)-3-hydroxybutyl (R)-3-hydroxybutyrate; ΔG®, University of Oxford; https://www.deltagketones.com) consumed 30 min prior to a mixed meal tolerance test, on 2 occasions during test day
Placebo
Placebo with stevia and bitter agent to flavour match
Placebo supplement
Placebo with stevia and bitter agent to flavour match, consumed 30 min prior to a mixed meal tolerance test, on 2 occasions during test day
Interventions
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Ketone supplement
100 mL flavoured drink containing 0.3 g/kg ketone monoester ((R)-3-hydroxybutyl (R)-3-hydroxybutyrate; ΔG®, University of Oxford; https://www.deltagketones.com) consumed 30 min prior to a mixed meal tolerance test, on 2 occasions during test day
Placebo supplement
Placebo with stevia and bitter agent to flavour match, consumed 30 min prior to a mixed meal tolerance test, on 2 occasions during test day
Eligibility Criteria
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Inclusion Criteria
2. Body mass index 27-40 mg/m²
3. Type 2 diagnosis for more than 1 year
4. HbA1c \>6%
Exclusion Criteria
2. Use of insulin
3. HbA1c \>10%
4. Recent weight loss (\>5kg in 6 months)
5. Recent eGFR \<30mL/min
6. Heart failure
7. Substance abuse
8. Cancer
9. Myocardial infarction within 6 months
10. Pregnancy or consideration of
11. Use of antipsychotic drugs
41 Years
70 Years
ALL
No
Sponsors
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University of British Columbia
OTHER
Medical Research Council
OTHER_GOV
University of Exeter
OTHER
Responsible Party
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Principal Investigators
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Francis B Stephens, PhD
Role: PRINCIPAL_INVESTIGATOR
University of Exeter
Locations
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Sport & Health Sciences University of Exeter
Exeter, Devon, United Kingdom
Countries
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Other Identifiers
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4765060
Identifier Type: -
Identifier Source: org_study_id
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