Outcomes Comparison Between Bone Resection and Subperiosteal Dissection for Specific Type of Soft Tissue Sarcoma

NCT ID: NCT06317480

Last Updated: 2024-03-19

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

142 participants

Study Classification

OBSERVATIONAL

Study Start Date

2000-05-01

Study Completion Date

2023-09-01

Brief Summary

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the purpose of this study is to assess whether bone resection for thigh soft tissue sarcoma with cortical involvement of the adjacent bone result in better local control and survival compared to sub-periosteal dissection. Investigators also aim to find out the prognostic factors for clinical outcomes in this group of patients.

Detailed Description

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Conditions

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Soft Tissue Sarcoma Cortical Contact

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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bone resection

bone resection

Intervention Type PROCEDURE

patients underwent soft tissue sarcoma excision together with bone resection following either biological or endoprosthesis reconstruction

subperiosteal excision

subperiosteal excision

Intervention Type PROCEDURE

patients underwent sub-periosteal tumor excision combining bone and soft tissue ablation without bone excision

Interventions

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bone resection

patients underwent soft tissue sarcoma excision together with bone resection following either biological or endoprosthesis reconstruction

Intervention Type PROCEDURE

subperiosteal excision

patients underwent sub-periosteal tumor excision combining bone and soft tissue ablation without bone excision

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

1. Patients developed thigh soft tissue sarcoma, defined as lesion located below the plane of the lesser trochanter and above the plane of the femoral condyle.
2. received primary limb-salvage surgery at our center.
3. soft tissue sarcoma with only cortical contact of the adjacent bone based on preoperative imaging
4. minimum of 2-year follow up

Exclusion Criteria

1. diagnosis was well differentiated liposarcoma
2. patients with metastatic disease at the time of presentation
3. soft tissue sarcoma displayed frank osseous invasion (eg. medullary canal invasion)
Minimum Eligible Age

8 Years

Maximum Eligible Age

85 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Second Affiliated Hospital, School of Medicine, Zhejiang University

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Zhaoming Ye

Role: PRINCIPAL_INVESTIGATOR

Second Affiliated Hospital, School of Medicine, Zhejiang University

Other Identifiers

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QH_2024

Identifier Type: -

Identifier Source: org_study_id

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