Australian Genomics Of Chronic Allograft Dysfunction Study

NCT ID: NCT06314230

Last Updated: 2025-07-17

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

500 participants

Study Classification

OBSERVATIONAL

Study Start Date

2012-04-26

Study Completion Date

2040-01-01

Brief Summary

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The goal of the Australian Genomics of Chronic Allograft Dysfunction (AUSCAD) study is a single centre (Westmead Hospital), prospective, observational study, which enrols patients at time of kidney (or kidney-transplant) transplant and tracks the post transplant course. The AUSCAD study aims to generate new knowledge and improve outcomes following kidney transplantation. The primary aim is to determine whether important outcomes (including chronic rejection and graft loss) are correlated with patterns of allograft reactivity, gene expression and susceptibility profiles.

Detailed Description

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Conditions

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Kidney Transplant Rejection Kidney Transplant; Complications

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Kidney transplant recipients

Kidney or kidney-pancreas transplant recipients enrolled into the study prospectively. Risk factors recorded, blood/urine/kidney samples analysed and correlated with outcomes.

Non-interventional, observational in nature.

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Living or deceased donor kidney transplant candidate.
* Biological sex: any
* Ages: 18-75 years.
* Subject must be able to understand and provide informed consent.
* Deceased donor individuals where Research Consent has been obtained from the person consenting to organ donation at the time of organ retrieval.
* Identifiable living donors who have received informed consent and have consented to participate in the project.

Exclusion Criteria

* Presensitization in living donor recipients prior to transplantation, as determined by site-specific standards, OR positive cross match according to site specific technique in cadaveric donor recipients.
* Recipients of multiple organ transplants, with the exception of kidney/pancreas transplants.
* Inability or unwillingness of a participant to give written informed consent or comply with study protocol
* High risk populations including pregnant women, children less than 18 years and prisoners will not be included in the study.
* Non English speaking potential participants who do not understand the requirements of the study will not be included.
Minimum Eligible Age

18 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Western Sydney Local Health District

OTHER

Sponsor Role lead

Responsible Party

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Jennifer Li

Nephrologist and Transplant Physician

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Westmead Hospital

Westmead, New South Wales, Australia

Site Status RECRUITING

Westmead Institute for Medical Research

Westmead, New South Wales, Australia

Site Status RECRUITING

Countries

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Australia

Central Contacts

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Jennifer SY Li, MBBS, FRACP

Role: CONTACT

Philip J O'Connell, MBBS, FRACP

Role: CONTACT

Facility Contacts

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Jennifer SY Li, MBBS, FRACP

Role: primary

Philip J O'Connell, MBBS, FRACP

Role: primary

Other Identifiers

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AUSCAD

Identifier Type: -

Identifier Source: org_study_id

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