Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
80 participants
INTERVENTIONAL
2024-09-01
2026-03-31
Brief Summary
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Objective 1) Muscle structure and function Hypothesis: Krill oil supplementation will increase muscle size and strength alongside positive changes in muscle architecture (pennation angle and fascicle length).
Objective 2) Neuromuscular control and central nervous system (CNS) function Hypothesis: Krill oil supplementation will improve Neuromuscular Junction (NMJ) transmission stability and increase central drive and intramuscular coherence, as a measure of muscle synergy.
Objective 3) Gait and functional characteristics Hypothesis: Krill oil supplementation will improve gait and functional characteristics.
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
PREVENTION
TRIPLE
Study Groups
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Vegetable oil
4g/day vegetable oil for 24 weeks
Vegetable oil
mixed vegetable oil
Krill oil
4/g/day krill oil for 24 weeks
Krill oil
Krill oil
Interventions
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Vegetable oil
mixed vegetable oil
Krill oil
Krill oil
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Age \>/= 65 years
* Capacity to consent
* Living within the Glasgow area
Exclusion Criteria
* Severe cardiovascular disease
* Seizure disorders
* Uncontrolled hypertension (\>150/90mmHg)
* Active cancer or cancer that has been in remission \<5 years
* Participation in any resistance exercise training within the last 6 months
* Impairments which may limit ability to perform assessments of muscle function
* Dementia
* Fish/shellfish allergy
* Taking medication known to affect muscle (e.g. steroids, Selective serotonin reuptake inhibitors) or anticoagulants (e.g. warfarin)
* Taking omega-3 supplements in the last 3 months
* Regularly consuming 1 or more portions of oily fish per week
* Not able to understand English
65 Years
90 Years
ALL
Yes
Sponsors
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University of Glasgow
OTHER
Responsible Party
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Stuart Gray
Professor of Muscle and Metabolic Health
Locations
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University of Glasgow
Glasgow, , United Kingdom
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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KAMM
Identifier Type: -
Identifier Source: org_study_id
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