TAS-102 Combined With Bevacizumab for Second-line Maintenance Treatment of Advanced Colorectal Cancer

NCT ID: NCT06293014

Last Updated: 2024-03-05

Basic Information

• Recruitment Status: RECRUITING
• Clinical Phase: PHASE2
• Total Enrollment: 224 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2024-02-23
• Study Completion Date: 2026-11-28

Brief Summary

This study is a randomized, controlled, open-label, multicentre clinical study. This study is designed to evaluate the efficacy and safety of TAS-102 combined with bevacizumab as second-line maintenance therapy versus standard chemotherapy combined with bevacizumab as second-line continuous therapy in advanced colorectal cancer after second-line induction therapy.

Detailed Description

This study is a randomized, controlled, open-label, multicentre clinical study. This study is designed to evaluate the efficacy and safety of TAS-102 combined with bevacizumab as second-line maintenance therapy versus standard chemotherapy combined with bevacizumab as second-line continuous therapy in advanced colorectal cancer after second-line induction therapy.

The primary endpoint is investigator-assessed time to treatment failure (TTF). Secondary endpoints include ORR, DCR, DoR, PFS, OS, safety and patient reported outcomes.

This study plans to enroll 224 patients with advanced colorectal cancer who have previously achieved disease control after second-line induction therapy with standard chemotherapy (FOLFOX, FOLFIRI, or CAPEOX) combined with bevacizumab.

The subjects will be randomly assigned in a 1:1 ratio to the TAS-102 combined with bevacizumab second-line maintenance treatment group (experimental group) and the standard chemotherapy combined with bevacizumab second-line continuous treatment group (control group).

Conditions

Colorectal Cancer

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

second-line maintenance treatment group

TAS-102 combined with bevacizumab

Group Type: EXPERIMENTAL

TAS-102+bevacizumab

Intervention Type: DRUG

TAS-102 35mg/m2, PO, D1-5, repeated every 14 days; Bevacizumab 5mg/kg, IV, D1, repeated every 14 days; Q4w.

second-line continuous treatment group

Standard chemotherapy (FOLFOX，FOLFIRI or CAPEOX) combined with bevacizumab

Group Type: ACTIVE_COMPARATOR

Standard chemotherapy+bevacizumab

Intervention Type: DRUG

Standard chemotherapy (chemotherapy regimen based on investigator's choice, including FOLFIRI, FOLFOX, or CAPEOX); Bevacizumab

Interventions

TAS-102+bevacizumab

TAS-102 35mg/m2, PO, D1-5, repeated every 14 days; Bevacizumab 5mg/kg, IV, D1, repeated every 14 days; Q4w.

Intervention Type: DRUG

Standard chemotherapy+bevacizumab

Standard chemotherapy (chemotherapy regimen based on investigator's choice, including FOLFIRI, FOLFOX, or CAPEOX); Bevacizumab

Intervention Type: DRUG

Other Intervention Names

Trifluridine and Tipiracil Hydrochloride Tablets; bevacizumab; Bevacizumab

Eligibility Criteria

Inclusion Criteria

1. Subjects voluntarily participate in this study, sign the informed consent form, and have good compliance;

2. Age ≥18 years old;

3. Unresectable colorectal adenocarcinoma confirmed by histopathology or cytology;

4. After receiving 12 weeks of standard chemotherapy (FOLFOX, FOLFIRI, or CAPEOX) combined with bevacizumab second-line induction therapy, the patients are confirmed as CR, PR, or SD according to RECIST 1.1 criteria;

5. The interval between the last second-line induction therapy and randomization is not more than 6 weeks;

6. At least one measurable lesion according to RECIST 1.1 criteria;

7. ECOG Performance Status 0-2;

8. Estimated life expectancy ≥12 weeks;

9. Adequate major organ function (no medication for blood component, cell growth factor correction therapy is allowed within 14 days before randomization);

10. Women of child-bearing potential must agree to abstain from sex (heterosexual intercourse) or use a reliable, effective method of contraception from the time they provide informed consent until at least 90 days after the last dose of study drug is administered. Serum or urine HCG test must be negative. And must be non-lactating;

11. Male participants whose partner is a woman of child-bearing potential must agree to abstain from sex or use a reliable,effective method of contraception from the time they sign an informed consent form until at least 90 days after the last dose of study drug is administered. Male subjects also have to agree not to donate sperm during the same period.

Exclusion Criteria

1. Any CTCAE grade 1 or above toxicity caused by previous treatment that has not yet subsided (excluding alopecia, skin pigmentation, and chemotherapy-induced neurotoxicity);

2. Known history or evidence of interstitial lung disease or active noninfectious pneumonia;

3. Poorly controlled hypertension (systolic blood pressure >150 mmHg and/or diastolic blood pressure >100 mmHg) with a previous history of hypertensive crisis or hypertensive encephalopathy;

4. Have bleeding tendency and high risk of bleeding;

5. Known inherited or acquired bleeding (e.g., coagulopathy) or thrombophilia, as in patients with hemophilia; Current or recent (within 10 days before initiation of study treatment) use of a full-dose oral or injectable anticoagulant or thrombolytic agent for therapeutic purposes (prophylactic use of low-dose aspirin and low-molecular-weight heparin is allowed);

6. Thrombotic or embolic events, such as cerebrovascular accident (including transient ischemic attack, cerebral hemorrhage, cerebral infarction), pulmonary embolism, etc., occurred within 6 months before the initiation of study treatment;

7. Severe, unhealed or dehiscence wounds and active ulcers or untreated fractures;

8. Has undergone major surgical treatment (excluding diagnosis) within 4 weeks before the start of the study or is expected to undergo major surgical treatment during the study period;

9. Inability to swallow tablets, malabsorption syndrome or any condition affecting gastrointestinal absorption;

10. Patients with congenital or acquired immune deficiency (such as HIV infection);

11. Active hepatitis (hepatitis B reference: HBsAg positive and HBV DNA≥2000 IU/ml; Hepatitis C reference: HCV antibody positive and HCV virus copy number > upper limit of normal);

12. Known brain and/or leptomeningeal metastases. All subjects should receive brain CT/MRI to exclude brain metastases;

13. Active infection or fever of unknown origin > 38.5 ° C within 2 weeks before the first dose (tumor-related fever, as judged by the investigator, was eligible);

14. Acute or subacute intestinal obstruction, or chronic inflammatory bowel disease;

15. Have poorly controlled cardiac clinical symptoms or disease；

16. Patients with other malignant tumors within 5 years before enrollment, except basal cell carcinoma of the skin or carcinoma in situ of the cervix;

17. Pregnant or lactating women;

18. Patients with genotype MSI-H;

19. Prior treatment with TAS-102;

20. Abdominal fistula, gastrointestinal perforation, or abdominal abscess within 6 months before study treatment;

21. The investigator assessed that it is not appropriate to participate in the study.

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Henan Cancer Hospital

OTHER_GOV

Sponsor Role: lead

Responsible Party

Ying Liu

Director

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Ying Liu, Dr

Role: PRINCIPAL_INVESTIGATOR

Henan Cancer Hospital

Locations

Henan Cancer Hospital/The affiliated Cancer Hospital of ZhengZhou university

Zhengzhou, Henan, China

Site Status: RECRUITING

Countries

China

Central Contacts

Ying Liu, Dr

Role: CONTACT

yaya7207@126.com

13783604602

Facility Contacts

Ying Liu, MD

Role: primary

Yaya7207@126.com

+86-13783604602

Other Identifiers

QLMA-CRC-IIT-001

Identifier Type: -

Identifier Source: org_study_id