Early Intervention to Promote Cardiovascular Health of Mothers and Children

NCT ID: NCT06272045

Last Updated: 2025-10-17

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

6618 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-06-19

Study Completion Date

2028-07-31

Brief Summary

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Early Intervention to Promote Cardiovascular Health of Mothers and Children (ENRICH) is a cluster randomized clinical trial, funded by the National Heart Lung \& Blood Institute. The study is designed to test the effectiveness of home visiting intervention to promote cardiovascular health and reduce disparities in maternal and early childhood cardiovascular health. Sites, in partnership with evidence-based home visiting programs, are recruiting 6618 participants in total (i.e., 3309 mother-child dyads which includes 3309 mothers and 3309 children) from diverse community settings with a high burden of cardiovascular disease risk factors.

Detailed Description

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Conditions

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Cardiovascular Health

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

DOUBLE

Participants Outcome Assessors
cluster randomized at the home visiting supervisor level, stratified within home visiting agencies

Participants are masked throughout the study enrollment process (e.g., recruitment, consent, and baseline data collection). Participant may become unmasked to treatment arm after enrollment.

Study Groups

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ENRICHed home visiting

Home Visiting with the addition of cardiovascular health promotion content

Group Type EXPERIMENTAL

ENRICH

Intervention Type BEHAVIORAL

In the ENRICH intervention, home visitors will incorporate heart health information and activities into routine home visits beginning in pregnancy and continuing until children turn 2 years old. The intervention includes 1) Information and resources on topics such as healthy eating, physical activity, weight management, tobacco use, healthy sleep and stress reduction, 2) tools like scales, Fitbits, and blood pressure monitors to facilitate self-monitoring, and 3) activities and information focused on infant nutrition, feeding, healthy growth, sleep, play and emotions and soothing.

Usual Home Visiting

Usual home visiting without cardiovascular health promotion content

Group Type ACTIVE_COMPARATOR

Usual Home Visiting

Intervention Type BEHAVIORAL

Usual home visiting without cardiovascular health promotion content

Interventions

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ENRICH

In the ENRICH intervention, home visitors will incorporate heart health information and activities into routine home visits beginning in pregnancy and continuing until children turn 2 years old. The intervention includes 1) Information and resources on topics such as healthy eating, physical activity, weight management, tobacco use, healthy sleep and stress reduction, 2) tools like scales, Fitbits, and blood pressure monitors to facilitate self-monitoring, and 3) activities and information focused on infant nutrition, feeding, healthy growth, sleep, play and emotions and soothing.

Intervention Type BEHAVIORAL

Usual Home Visiting

Usual home visiting without cardiovascular health promotion content

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

1. Be currently enrolled in an evidence-based home visiting program participating in ENRICH
2. Be pregnant, with a single or multifetal gestation, at or less than 34 weeks 0 days gestation (per self-report at time of consent)
3. Be 18 years of age or older
4. Speak English or Spanish
Minimum Eligible Age

18 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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National Heart, Lung, and Blood Institute (NHLBI)

NIH

Sponsor Role collaborator

JHSPH Center for Clinical Trials

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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University of Alabama at Birmingham

Birmingham, Alabama, United States

Site Status RECRUITING

California Polytechnic State University

San Luis Obispo, California, United States

Site Status RECRUITING

University of Colorado

Aurora, Colorado, United States

Site Status RECRUITING

Northwestern University

Chicago, Illinois, United States

Site Status RECRUITING

Washington University in St. Louis

St Louis, Missouri, United States

Site Status RECRUITING

Wake Forest University

Winston-Salem, North Carolina, United States

Site Status RECRUITING

University of Pittsburgh

Pittsburgh, Pennsylvania, United States

Site Status RECRUITING

Pennsylvania State University

State College, Pennsylvania, United States

Site Status RECRUITING

Brown University/Lifespan

Providence, Rhode Island, United States

Site Status RECRUITING

Countries

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United States

Central Contacts

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Lori Burrell, MSW

Role: CONTACT

724-858-8201

Facility Contacts

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Amy Dobelstein

Role: primary

205-975-1059

Noemi Alarcon

Role: primary

805-756-5694

Natalie Murphy

Role: primary

970-581-3018

Katharine Maroun

Role: primary

312-503-3019

Cindy Schwartz

Role: primary

314-346-7101

Natalie Murphy

Role: primary

970-581-3018

Brianna Natale

Role: primary

412-624-4020

Lindsey Hess

Role: primary

814-934-7631

Angelica McHugh

Role: primary

401-793-8978

Other Identifiers

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5U24HL163114

Identifier Type: NIH

Identifier Source: secondary_id

View Link

IRB00398712

Identifier Type: -

Identifier Source: org_study_id

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