Comparative Efficacy of Hypertonic Saline vs Adrenaline Nebulization in Acute Bronchiolitis
NCT ID: NCT06267118
Last Updated: 2024-08-22
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
PHASE3
60 participants
INTERVENTIONAL
2023-11-01
2024-12-31
Brief Summary
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1. Improvement in Wood-Downes clinical score (WDF score) in bronchiolitis
2. Length of Hospitalization
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
DOUBLE
Study Groups
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Hypertonic saline nebulization group
First group of patients diagnosed as acute bronchiolitis will be nebulized with hypertonic saline every 6 hours and data will be recorded on a Performa
Hypertonic Saline Solution, 1 Ml
Dilute 0.3 ml hypertonic saline with 3 ml normal saline for nebulization
Adrenaline nebulization group
Second group of patients will be nebulized with adrenaline every 6 hours and data will be recorded on a Performa
Adrenaline
dilute 0.3 ml adrenaline with 3 ml normal saline for nebulization
Interventions
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Hypertonic Saline Solution, 1 Ml
Dilute 0.3 ml hypertonic saline with 3 ml normal saline for nebulization
Adrenaline
dilute 0.3 ml adrenaline with 3 ml normal saline for nebulization
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
1. Congenital Heart Disease
2. Immunodeficiency
3. other Infectious disease like Meningitis, encephalitis, Pneumonia, TORCH
4. Kidneys or liver problem
5. Seizures
1 Month
2 Years
ALL
No
Sponsors
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Combined Military Hospital, Pakistan
OTHER
Responsible Party
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Syed Qamar Zaman
Assistant Professor & Head of Pediatrics Department
Principal Investigators
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Prof Shahid Mahmud
Role: STUDY_DIRECTOR
Military Hospital Rawalpindi
Locations
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Combined Military Hospital
Nowshera, KPK, Pakistan
Countries
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Central Contacts
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Facility Contacts
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References
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Piedimonte G, Perez MK. Respiratory syncytial virus infection and bronchiolitis. Pediatr Rev. 2014 Dec;35(12):519-30. doi: 10.1542/pir.35-12-519. No abstract available.
Anil AB, Anil M, Saglam AB, Cetin N, Bal A, Aksu N. High volume normal saline alone is as effective as nebulized salbutamol-normal saline, epinephrine-normal saline, and 3% saline in mild bronchiolitis. Pediatr Pulmonol. 2010 Jan;45(1):41-7. doi: 10.1002/ppul.21108.
Florin TA, Plint AC, Zorc JJ. Viral bronchiolitis. Lancet. 2017 Jan 14;389(10065):211-224. doi: 10.1016/S0140-6736(16)30951-5. Epub 2016 Aug 20.
Grewal S, Ali S, McConnell DW, Vandermeer B, Klassen TP. A randomized trial of nebulized 3% hypertonic saline with epinephrine in the treatment of acute bronchiolitis in the emergency department. Arch Pediatr Adolesc Med. 2009 Nov;163(11):1007-12. doi: 10.1001/archpediatrics.2009.196.
Zhang L, Mendoza-Sassi RA, Wainwright C, Klassen TP. Nebulised hypertonic saline solution for acute bronchiolitis in infants. Cochrane Database Syst Rev. 2017 Dec 21;12(12):CD006458. doi: 10.1002/14651858.CD006458.pub4.
Hariprakash S, Alexander J, Carroll W, Ramesh P, Randell T, Turnbull F, Lenney W. Randomized controlled trial of nebulized adrenaline in acute bronchiolitis. Pediatr Allergy Immunol. 2003 Apr;14(2):134-9. doi: 10.1034/j.1399-3038.2003.00014.x.
Fretzayas A, Moustaki M. Etiology and clinical features of viral bronchiolitis in infancy. World J Pediatr. 2017 Aug;13(4):293-299. doi: 10.1007/s12519-017-0031-8. Epub 2017 May 4.
Related Links
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RCTnebulized epinephrine versus nebulized hypertonic saline in infants with acute bronchiolitis
Viral bronchiolitis in children: A common condition with few therapeutic options
Other Identifiers
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Treatment of Bronchiolitis
Identifier Type: -
Identifier Source: org_study_id
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